Vinegar extract ameliorates alcohol-induced liver damage associated with the modulation of gut microbiota in mice

Wang, Min; Zhang, Bo; Li, Shaopeng; Fang, Bin; Duan, Wenhui; Zhang, Jin; Song, Jia; Wang, Min

doi:10.1039/c9fo03015h

Cited by 48 publications

(32 citation statements)

References 54 publications

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“…A previous study also demonstrated that stress and infection could result in a significant decrease in the SCFA-producing genera, such as Butyricimonas , Anaerostipes , Butyricicoccus , Coprococcus , and Parabacteroides [ 48 ]. Akkermansia and Lactobacillus showed a significant positive correlation with intestinal tight junction proteins and a negative correlation with inflammation and oxidative stress [ 49 ]. The triathletes participate in extremely high-intensity triathlon competition, and follow daily programmed training for higher sports-related physical fitness.…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus plantarum PS128 Improves Physiological Adaptation and Performance in Triathletes through Gut Microbiota Modulation

et al. 2020

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A triathlon is an extremely high-intensity exercise and a challenge for physiological adaptation. A triathlete’s microbiome might be modulated by diet, age, medical treatments, lifestyle, and exercise, thereby maintaining aerobiosis and optimum health and performance. Probiotics, prebiotics, and synbiotics have been reported to have health-promoting activities (e.g., immunoregulation and cancer prevention). However, few studies have addressed how probiotics affect the microbiota of athletes and how this translates into functional activities. In our previous study, we found that Lactobacillus plantarum PS128 could ameliorate inflammation and oxidative stress, with improved exercise performance. Thus, here we investigate how the microbiota of triathletes are altered by L. plantarum PS128 supplementation, not only for exercise performance but also for possible physiological adaptation. The triathletes were assigned to two groups: an L. plantarum 128 supplement group (LG, 3 × 1010 colony-forming units (CFU)/day) and a placebo group (PG). Both groups continued with their regular exercise training for the next 4 weeks. The endurance performance, body composition, biochemistries, blood cells, microbiota, and associated metabolites were further investigated. PS128 significantly increased the athletes’ endurance, by about 130% as compared to the PG group, but there was no significant difference in maximal oxygen consumption (VO2max) and composition between groups. The PS128 supplementation (LG) modulated the athlete’s microbiota with both significant decreases (Anaerotruncus, Caproiciproducens, Coprobacillus, Desulfovibrio, Dielma, Family_XIII, Holdemania, and Oxalobacter) and increases (Akkermansia, Bifidobacterium, Butyricimonas, and Lactobacillus), and the LG showed lower diversity when compared to the PG. Also, the short-chain fatty acids (SCFAs; acetate, propionate, and butyrate) of the LG were significantly higher than the PG, which might be a result of a modulation of the associated microbiota. In conclusion, PS128 supplementation was associated with an improvement on endurance running performance through microbiota modulation and related metabolites, but not in maximal oxygen uptake.

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Section: Discussionmentioning

confidence: 99%

Lactobacillus plantarum PS128 Improves Physiological Adaptation and Performance in Triathletes through Gut Microbiota Modulation

et al. 2020

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“…Besides, the H-Mg group presented a significant increase of Butyricimonas and Parabacteroides. Recently, Xia et al negatively correlated Proteobacteria, Butyricimonas, Parabacteroides, and Bilophila abundance with liver inflammation and intestinal epithelial claudin expression [33]. Moreover, Victivallis and Butyricimonas abundance have been positively correlated with hepatic lipid accumulation [34].…”

Section: Discussionmentioning

confidence: 99%

Effect of Dietary Magnesium Content on Intestinal Microbiota of Rats

et al. 2020

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Background: Magnesium is a mineral that modulates several physiological processes. However, its relationship with intestinal microbiota has been scarcely studied. Therefore, this study aimed to assess the role of dietary magnesium content to modulate the intestinal microbiota of Wistar male rats. Methods: Rats were randomly assigned one of three diets: a control diet (C-Mg; 1000 mg/kg), a low magnesium content diet (L-Mg; 60 mg/kg), and a high magnesium content diet (H-Mg; 6000 mg/kg), for two weeks. After treatment, fecal samples were collected. Microbiota composition was assessed by sequencing the V3–V4 hypervariable region. Results: The C-Mg and L-Mg groups had more diversity than H-Mg group. CF231, SMB53, Dorea, Lactobacillus and Turibacter were enriched in the L-Mg group. In contrast, the phyla Proteobacteria, Parabacteroides, Butyricimonas, and Victivallis were overrepresented in the H-Mg group. PICRUSt analysis indicated that fecal microbiota of the L-Mg group were encoded with an increased abundance of metabolic pathways involving carbohydrate metabolism and butanoate metabolism. Conclusion: Dietary magnesium supplementation can result in intestinal dysbiosis development in a situation where there is no magnesium deficiency. Conversely, low dietary magnesium consumption is associated with microbiota with a higher capacity to harvest energy from the diet.

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“…Hence, we could preliminarily deduce the CCP could adjust the changes of two main phyla to produce prebiotic-like effects [22][23][24]. Verrucomicrobia was considered as a probiotic, which showed a negative correlation with hepatic inflammation and oxidative stress [25,26]. Especially, Akkermansiaceae, the most representative gut microbe in the Verrucomicrobia, could prevent the weight gain caused by a high-fat diet, repair the damaged integrity of the intestinal epithelium barrier, reduce endotoxin levels in the blood, and improve insulin resistance [27,28].…”

Section: Discussionmentioning

confidence: 99%

The Prebiotic‐Like Effects of Coprinus comatus Polysaccharides on Gut Microbiota in Normal Mice and Those with Acute Alcoholic Liver Injury: A Comparative Study

Wang

Sun

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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This study aims to investigate the prebiotic-like effects of Coprinus comatus polysaccharides (CCP) on gut microbiota. Mice were divided into four groups: normal group (NG), alcohol group (AG), polysaccharides group (PG), and alcohol + polysaccharides group (APG). The gut microbiota structure of feces was analyzed by determining the V3-V4 region sequence in 16S rDNA. The results showed CCP could increase the diversity of gut microbiota. Compared with NG, PG had a significantly higher relative abundance of Firmicutes and Lactobacillaceae and a lower abundance of Rikenellaceae. These changes in gut microbiota result in positive effects on gut due to a series of prebiotic-like effects of CCP. At the same time, CCP could improve some adverse changes in gut microbiota caused by acute alcohol intake, such as the increased proportion of Firmicutes, Bacteroidetes, Muribaculaceae, and Lachnospiraceae and the decreased proportion of Rikenellaceae. In conclusion, the CCP has certain prebiotic effects not only on normal mice but also on mice with acute alcoholic liver injury.

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Vinegar extract ameliorates alcohol-induced liver damage associated with the modulation of gut microbiota in mice

Abstract: Vinegar extract inhibited alcohol-induced ROS generation and inflammation. Vinegar extract modulated gut microbiota and improved intestinal homeostasis, which could be used as a novel gut microbiota manipulator against alcohol-induced liver damage.

Cited by 48 publications

References 54 publications

Lactobacillus plantarum PS128 Improves Physiological Adaptation and Performance in Triathletes through Gut Microbiota Modulation

Lactobacillus plantarum PS128 Improves Physiological Adaptation and Performance in Triathletes through Gut Microbiota Modulation

Effect of Dietary Magnesium Content on Intestinal Microbiota of Rats

The Prebiotic‐Like Effects of Coprinus comatus Polysaccharides on Gut Microbiota in Normal Mice and Those with Acute Alcoholic Liver Injury: A Comparative Study

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