Vinpocetine☆

Willson, C.

doi:10.1016/b978-0-12-801238-3.99480-7

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…It is recommended that users take only 2-5 mg for the first time to ensure that they do not have a hypersensitive reaction to it. They can then increase the dose to 10-30 mg daily [118,119], a dose that can cause some side effects, although very rarely, including nausea, dry mouth, dizziness, headache, and heartburn [120]. The use of vinpocetine is contraindicated during lactation and pregnancy [121].…”

Section: Vinpocetinementioning

confidence: 99%

Nootropics as Cognitive Enhancers: Types, Dosage and Side Effects of Smart Drugs

Malík

Tlustos

2022

Nutrients

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Nootropics, also known as “smart drugs” are a diverse group of medicinal substances whose action improves human thinking, learning, and memory, especially in cases where these functions are impaired. This review provides an up-to-date overview of the potential effectiveness and importance of nootropics. Based on their nature and their effects, this heterogeneous group of drugs has been divided into four subgroups: classical nootropic compounds, substances increasing brain metabolism, cholinergic, and plants and their extracts with nootropic effects. Each subgroup of nootropics contains several main representatives, and for each one, its uses, indications, experimental treatments, dosage, and possible side effects and contraindications are discussed. For the nootropic plant extracts, there is also a brief description of each plant representative, its occurrence, history, and chemical composition of the medicinal part. Lastly, specific recommendations regarding the use of nootropics by both ill and healthy individuals are summarized.

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Section: Vinpocetinementioning

confidence: 99%

Nootropics as Cognitive Enhancers: Types, Dosage and Side Effects of Smart Drugs

Malík

Tlustos

2022

Nutrients

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“…Vinpocetine (Figure 1) is a semi-synthetic derivative of vincamine [4], or more precisely, it is a derivative (ethyl ester) of apovincamine which is a reaction product of heating vincamine at very high temperatures [5]. Vinpocetine was firstly marketed in Hungary as Cavinton ® by Gedeon Richter Ltd., Budapest, Hungary (formerly Organon), and it is one of their best-selling products in their central nervous system portfolio to this day [6].…”

Section: Introductionmentioning

confidence: 99%

Clinical Pharmacology of Vinpocetine: Properties Revisited and Introduction of a Population Pharmacokinetic Model for Its Metabolite, Apovincaminic Acid (AVA)

Petric,

Paixão,

Filipe

et al. 2023

Pharmaceutics

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This paper examines the use of vinpocetine in the context of clinical pharmacology. The main and active metabolite of vinpocetine is apovincaminic acid (AVA). Due to the scarce information in the literature on AVA pharmacokinetics, we propose a population pharmacokinetic (PopPK) model for AVA based on a study in healthy volunteers with three different formulations of vinpocetine. The suggested PopPK model (and simulations) could be helpful in ensuring the more effective and safer use of the vinpocetine in the future given the increasing range of suggested indications for its use.

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Cognitive Impairment and Nootropic Drugs: Mechanism of Action and Spectrum of Effects

Voronina

2023

Nejrohimiâ

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The review provides information about the features of cognitive dysfunctions that occur in various diseases and conditions, and data on the history of the creation and characteristic features of nootropics. The review presents the mechanisms of action and the spectrum of pharmacological effects of nootropic drugs from various groups: drugs that affect brain metabolism, neurotransmitter systems (cholinergic, glutamatergic, gabaergic and others), cerebral vasodilators, neuropeptides and their analogues, antioxidants, membrane protectors and others. The free radical and mitochondrial concepts of aging and the possibility of using nootropics for the correction of cognitive impairments arising from aging, dementia and other neurodegenerative diseases are considered.

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Vinpocetine☆

Cited by 3 publications

References 9 publications

Nootropics as Cognitive Enhancers: Types, Dosage and Side Effects of Smart Drugs

Nootropics as Cognitive Enhancers: Types, Dosage and Side Effects of Smart Drugs

Clinical Pharmacology of Vinpocetine: Properties Revisited and Introduction of a Population Pharmacokinetic Model for Its Metabolite, Apovincaminic Acid (AVA)

Cognitive Impairment and Nootropic Drugs: Mechanism of Action and Spectrum of Effects

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