Viola yedoensis Makino alleviates heat stress-induced inflammation, oxidative stress, and cell apoptosis in the spleen and thymus of broilers

Mao, Yan; Kong, Xiangyi; Liang, Zengenni; Yang, Chenglin; Wang, Siqi; Fan, Hui; Ning, Can; Xiao, Wenguang; Wu, You; Wu, Jing; Yuan, Liyun; Yuan, Zhihang

doi:10.1016/j.jep.2023.117350

Cited by 4 publications

(1 citation statement)

References 41 publications

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“…The liver and spleen coe cient can re ect the toxicity of the preparation. The coe cients of liver and spleen increased, indicating organ congestion, edema, and hyperplasia [37,38]. As shown in Fig.…”

Section: In Vivo Biosafety Assessmentmentioning

confidence: 99%

Synergetic treatment of dihydroartemisinin and perillyl alcohol by liposomal nanoplatform for enhanced therapy of cerebral malaria and neurological injury alleviation in C57BL/6J mice

Ren,

Wang,

Jin

et al. 2024

Preprint

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To improve the efficacy of artemisinins against cerebral malaria (CM) in murine, dihydroartemisinin (DHA) and perillyl alcohol (POH) co-loaded liposomes (DP@Tyr-Lips) were designed and prepared, in which POH was expected to exert neuroprotective effects and synergistic therapeutic effects with DHA against CM. Furtherly, tyrosine (Tyr)acted as a substrate of LAT1 transporter could target the brain tissue, was used to modify Lips for improving the accumulation of drugs in the brain via BBB amino acid transporters. DP@Tyr-Lips were prepared with uniform particle size of 91.99 ± 2.67 nm, excellent physical and serum stability, and property of anti-phagocyte phagocytosis. The cumulative release percentages of DHA and POH from DP@Tyr-Lips at 24 h were 66.91 % ± 1.56 % and 58.77 % ± 0.31%, respectively, showing a certain sustained release behavior. Importantly, the inhibition rate of plasmodium of DP@Tyr-Lips was higher than that of DHA-sol. Furthermore, DP@Tyr-Lips could obviously accumulate in the brain and effectively inhibit the occurrence and development of CM, and prolong the survival time of CM mice due to its better biological safety. These findings illustrated that the combination DHA with POH in Tyr modified Lips could achieve the synergistic therapeutic effect and exhibit a significantly enhanced inhibitory effect on the growth of plasmodium, and also improve the neurological injury in a mouse model of CM.

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Section: In Vivo Biosafety Assessmentmentioning

confidence: 99%

Synergetic treatment of dihydroartemisinin and perillyl alcohol by liposomal nanoplatform for enhanced therapy of cerebral malaria and neurological injury alleviation in C57BL/6J mice

Ren,

Wang,

Jin

et al. 2024

Preprint

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Effect of dietary aspirin eugenol ester on the growth performance, antioxidant capacity, intestinal inflammation, and cecal microbiota of broilers under high stocking density

Zhang,

Bai

et al. 2024

Poultry Science

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Mechanisms of Heat Stress on Neuroendocrine and Organ Damage and Nutritional Measures of Prevention and Treatment in Poultry

Huang,

Cai,

Han

et al. 2024

Biology

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Heat stress (HS) due to high temperatures has adverse effects on poultry, including decreased feed intake, lower feed efficiency, decreased body weight, and higher mortality. There are complex mechanisms behind heat stress in poultry involving the neuroendocrine system, organ damage, and other physiological systems. HS activates endocrine glands, such as the pituitary, adrenal, thyroid, and gonadal, by the action of the hypothalamus and sympathetic nerves, ultimately causing changes in hormone levels: HS leads to increased corticosterone levels, changes in triiodothyronine and thyroxine levels, decreased gonadotropin levels, reduced ovarian function, and the promotion of catecholamine release, which ultimately affects the normal productive performance of poultry. Meanwhile, heat stress also causes damage to the liver, lungs, intestines, and various immune organs, severely impairing organ function in poultry. Nutrient additives to feed are important measures of prevention and treatment, including natural plants and extracts, probiotics, amino acids, and other nutrients, which are effective in alleviating heat stress in poultry. Future studies need to explore the specific mechanisms through which heat stress impacts the neuroendocrine system in poultry and the interrelationships between the axes and organ damage so as to provide an effective theoretical basis for the development of preventive and treatment measures.

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Viola yedoensis Makino alleviates heat stress-induced inflammation, oxidative stress, and cell apoptosis in the spleen and thymus of broilers

Cited by 4 publications

References 41 publications

Synergetic treatment of dihydroartemisinin and perillyl alcohol by liposomal nanoplatform for enhanced therapy of cerebral malaria and neurological injury alleviation in C57BL/6J mice

Synergetic treatment of dihydroartemisinin and perillyl alcohol by liposomal nanoplatform for enhanced therapy of cerebral malaria and neurological injury alleviation in C57BL/6J mice

Effect of dietary aspirin eugenol ester on the growth performance, antioxidant capacity, intestinal inflammation, and cecal microbiota of broilers under high stocking density

Mechanisms of Heat Stress on Neuroendocrine and Organ Damage and Nutritional Measures of Prevention and Treatment in Poultry

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