Viola Yedoensis Suppresses Cell Invasion by Targeting the Protease and NF-κB Activities in A549 and Lewis Lung Carcinoma Cells

Huang, She-Fang; Chu, Shu‐Chen; Hsieh, Yi‐Hsien; Chen, Pei‐Ni; Hsieh, Yih‐Shou

doi:10.7150/ijms.22793

Cited by 11 publications

(5 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Huang et al suggested that Viola Yedoensis extract (VYE) regulated MMP-2 and uPA expression via the down-regulation of NF-κB pathway. Due to this process, VYE potentially suppressed the invasion, migration, and proteinase activities of A549 and Lewis lung carcinoma (LLC) cells, which consequently contributed to the inhibition of lung cancer cell metastasis [ 49 ]. Fan et al confirmed the capability of BushenShugan Formula (BSF) to inhibit proliferation, invasion, and cancer stem cell (CSC) properties of A549 cells, decrease colony formation, and induce cell apoptosis.…”

Section: Resultsmentioning

confidence: 99%

Recent Advances in Anti-Metastatic Approaches of Herbal Medicines in 5 Major Cancers: From Traditional Medicine to Modern Drug Discovery

et al. 2021

View full text Add to dashboard Cite

Metastasis is the main cause of cancer-related death. Despite its high fatality, a comprehensive study that covers anti-metastasis of herbal medicines has not yet been conducted. The aim of this study is to investigate and assess the anti-metastatic efficacies of herbal medicines in the five major cancers, including lung, colorectal, gastric, liver, and breast cancers. We collected articles published within five years using PubMed, Google Scholar, and Web of Science with “cancer metastasis” and “herbal medicine” as keywords. Correspondingly, 16 lung cancer, 23 colorectal cancer, 10 gastric cancer, 10 liver cancer, and 18 breast cancer studies were systematically reviewed. The herbal medicines attenuated metastatic potential targeting various mechanisms such as epithelial mesenchymal transition (EMT), reactive oxygen species (ROS), and angiogenesis. Specifically, the drugs regulated metastasis related factors such as matrix metalloproteinase (MMP), serine-threonine protein kinase/extracellular regulated protein kinase (AKT/ERK), angiogenic factors, and chemokines. Overall, the present study is the first review, comprehensively investigating the anti-metastasis effect of herbal medicines on five major cancers, providing the experimental models, doses and durations, and mechanisms. Herbal medicines could be a potent candidate for anti-metastatic drugs.

show abstract

Section: Resultsmentioning

confidence: 99%

Recent Advances in Anti-Metastatic Approaches of Herbal Medicines in 5 Major Cancers: From Traditional Medicine to Modern Drug Discovery

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Therefore, under the targeting effect of exosomes and the effect of EPR, drugs can better target the tumor site and exert a therapeutic effect. From the H&E staining of major organs, it could be found that there were slight voids appearing in the cytoplasm of the liver, lung and kidney in each administration group, especially in the lung, this may be related to the high metastasis of A549 tumor cells (Huang et al, 2018 ), while from the H&E staining of tumor, the Cy5.5-EXO-DTX presented better antitumor efficacy in A549 tumor-bearing mice models than Cy5.5-DTX group. This may be due to the targeting of drugs after the inclusion of exosomes, which can guide the specific delivery of drugs to tumor tissues, improve the efficacy.…”

Section: Discussionmentioning

confidence: 99%

Docetaxel-loaded exosomes for targeting non-small cell lung cancer: preparation and evaluation in vitro and in vivo

et al. 2021

View full text Add to dashboard Cite

Non-small cell lung cancer (NSCLC) is a highly lethal disease and the majority of NSCLC patients are desperate for therapies that can effectively target their cancer and ultimately improve their overall survival. Docetaxel (DTX) represents the first-line of the antitumor agent that is used to treat NSCLC; however, it has poor solubility in water and unsatisfactory encapsulation efficiency. In our study, exosomes were isolated from A549 cancer cells by ultracentrifugation and then characterized using transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), and Western blot (WB). The particle size changes of EXO and EXO-DTX were measured daily for seven days to test the stability. DTX was selected payload by electroporation (EXO-DTX). For the in vitro evaluation, cell proliferation, cell cycle, cell apoptosis, reactive oxygen species (ROS) assay and cellular uptake were evaluated in the A549 cells. Also, this study evaluated the target and therapeutic effect of DTX as an antitumor agent in vivo. As a result, EXO-DTX with a particle size of 149.5 nm were successfully prepared and the cytotoxicity of the EXO-DTX was much greater than that of DTX monomers. Exosomes significantly increased the cellular uptake in vitro evaluation and showed better targeting to tumor tissue compared to the free DTX in the mice. We also explored the potential of tumor cell-derived exosomes as a drug delivery agent to target the parent cancer. Hence, we conclude that exosomes might be used as a potential antitumor drug delivery system (DDS).

show abstract

“…Further research showed that VYE inhibits the binding of NF-κB to DNA. Thus, the inhibition of NF-κB suppresses MMP-2 and u-PA expression and lung cancer cell invasion [ 46 ]. Focal adhesion kinase (FAK) was found to be overexpressed and activated in some late-stage cancers.…”

Section: Effects Of Natural Products On the Tumor Microenvironmentmentioning

confidence: 99%

Natural Products with Activity against Lung Cancer: A Review Focusing on the Tumor Microenvironment

Yang

Wang

et al. 2021

IJMS

View full text Add to dashboard Cite

Lung cancer is one of the most prevalent malignancies worldwide. Despite the undeniable progress in lung cancer research made over the past decade, it is still the leading cause of cancer-related deaths and continues to challenge scientists and researchers engaged in searching for therapeutics and drugs. The tumor microenvironment (TME) is recognized as one of the major hallmarks of epithelial cancers, including the majority of lung cancers, and is associated with tumorigenesis, progression, invasion, and metastasis. Targeting of the TME has received increasing attention in recent years. Natural products have historically made substantial contributions to pharmacotherapy, especially for cancer. In this review, we emphasize the role of the TME and summarize the experimental proof demonstrating the antitumor effects and underlying mechanisms of natural products that target the TME. We also review the effects of natural products used in combination with anticancer agents. Moreover, we highlight nanotechnology and other materials used to enhance the effects of natural products. Overall, our hope is that this review of these natural products will encourage more thoughts and ideas on therapeutic development to benefit lung cancer patients.

show abstract

Viola Yedoensis Suppresses Cell Invasion by Targeting the Protease and NF-κB Activities in A549 and Lewis Lung Carcinoma Cells

Cited by 11 publications

References 33 publications

Recent Advances in Anti-Metastatic Approaches of Herbal Medicines in 5 Major Cancers: From Traditional Medicine to Modern Drug Discovery

Recent Advances in Anti-Metastatic Approaches of Herbal Medicines in 5 Major Cancers: From Traditional Medicine to Modern Drug Discovery

Docetaxel-loaded exosomes for targeting non-small cell lung cancer: preparation and evaluation in vitro and in vivo

Natural Products with Activity against Lung Cancer: A Review Focusing on the Tumor Microenvironment

Contact Info

Product

Resources

About