We have developed a broadly-applicable approach that drastically increases the ability to accurately predict properties of complex atoms. We applied it to the case of Ir 17+ , which is of particular interest for the development of novel atomic clocks with high sensitivity to the variation of the finestructure constant and dark matter searches. The clock transitions are weak and very difficult to identity without accurate theoretical predictions. In the case of Ir 17+ , even stronger electric-dipole (E1) transitions eluded observation despite years of effort raising the possibility that theory predictions are grossly wrong. In this work, we provide accurate predictions of transition wavelengths and E1 transition rates in Ir 17+ . Our results explain the lack of observation of the E1 transitions and provide a pathway towards detection of clock transitions. Computational advances demonstrated in this work are widely applicable to most elements in the periodic table and will allow to solve numerous problems in atomic physics, astrophysics, and plasma physics.High resolution optical spectroscopy of highly charged ions (HCI) became a subject of much recent interest due to novel applications for the development of atomic clocks and search for new physics beyond the standard model of elementary particles [1][2][3][4]. HCI optical clock proposals, fundamental physics applications, and experimental progress towards HCI high-precision spectroscopy were recently reviewed in [4]. HCI have numerous optical transitions between long-lived states suitable for development of clocks with very low uncertainties, estimated to reach 10 −19 level [5][6][7][8]. A particular attraction of HCI clock transitions is their exceptionally high sensitivity to a variation of the fine-structure constant α and, subsequently to dark matter searches [2][3][4].In many theories beyond the standard model, in particular those involving light scalar fields that naturally appear in cosmological models, the fundamental constants become dynamical (i.e. varying) [9][10][11][12][13][14]. If the fundamental constants, such as α, exhibit space-time variation, so are atomic spectra and clock frequencies, which is potentially detectable with atomic clocks. The dimensionless factor K quantifies the α-variation sensitivitywhere α 0 is the current value of α [15] and ∆E 0 is the clock transition energy corresponding to α 0 . Experimentally, variation of α is probed by monitoring the ratio of two clock frequencies with different values of K. Most of the currently operating atomic clocks have |K| < 1, with the Yb + octupole transition having the highest K = −6 [16]. HCI transitions allow for much higher sensitivities, with |K| > 100 making them particularly attractive candidates for these studies [2][3][4].It was recently shown that coupling of ultralight scalar dark matter to the standard model leads to oscillations of fundamental constants and, therefore, may be observed in clock-comparison experiments [11,17,18]. In addition, dark matter objects with large spatial ...