“…But, it is not only upbringing that shapes the life course. There are a present environment being faced [82] , [99] , [111] , [112] , [115] , [116] , [117] and a past including an inheritance [76] , [118] , [119] . Different exposures in different time periods are intertwined in an accumulating fashion [28] , [83] , [85] , [99] , [112] , [120] or in certain critical periods [74] , [75] , [96] , [99] , [106] , [121] , [122] with potentially negative stress as outcomes [101] , [105] , [107] , [123] , [124] , [125] , [126] , [127] , [128] .…”