“…In the case of sensation seeking, this would generate a synergistic effect with the direct effects already caused by substance use at the behavioral level, making the appearance of aggression, anger, risky behavior, and antisocial behavior even more likely [ 19 , 20 , 23 , 26 , 29 , 30 ]. On the other hand, the mediating role of contextual problems is framed in the neurological effects of drug use in adolescence, generating alterations that hinder emotional regulation and make non-adaptive aggression responses more frequent in problematic situations with school, peers, or family [ 7 , 8 , 39 , 40 ].…”