Violent suicide attempt history in elderly patients with bipolar disorder: The role of sex, abdominal obesity, and verbal memory: Results from the FACE-BD cohort (FondaMental Advanced center of Expertise for Bipolar Disorders)

Lengvenyte, Aiste; Aouizerate, Bruno; Aubin, V.; Loftus, J.; Marlinge, Emeline; Belzeaux, Raoul; Dubertret, Caroline; Gard, Sébastien; Haffen, Emmanuel; Schwan, Raymund; Llorca, Pierre‐Michel; Passerieux, Christine; Roux, Paul; Polosan, Mircea; Étain, Bruno; Leboyer, Marion; Courtet, Philippe; Olié, Émilie

doi:10.1016/j.jad.2021.09.097

Cited by 9 publications

(2 citation statements)

References 87 publications

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“…On the other hand, different studies showed a robust association between obesity and violent suicide attempts [ 71 , 72 ]. Some authors suggested that some clinical features, such as rapid cycling and depression with atypical features, can explain the association between obesity and suicide attempts in BD [ 69 , 73 ]. Moreover, obesity seems to worsen the cognition of bipolar patients, particularly their verbal memory and frontal abilities, with a more pronounced effect on violent suicide attempters [ 72 ].…”

Section: Discussionmentioning

confidence: 99%

Which Clinical and Biochemical Parameters Are Associated with Lifetime Suicide Attempts in Bipolar Disorder?

et al. 2022

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Introduction: Bipolar Disorder (BD) is a disabling condition with suicidal behavior as one of the most common adverse outcomes. The purpose of the present research is to investigate the relationship between lifetime suicide attempts and the clinical factors/biochemical parameters in a large sample of bipolar patients. Methods: A total of 561 patients, consecutively hospitalized for BD in Milan and Monza (Italy), were recruited. Data about the demographic and clinical variables, as well as the values of blood analyses, were collected. The groups identified according to the presence/absence of lifetime suicide attempts were compared using univariate analyses. Then, three preliminary binary logistic regressions and a final logistic regression model were performed to identify the clinical and biochemical parameters associated with lifetime suicide attempts in BD. Results: Lifetime suicide attempts in BD were predicted by a longer duration of untreated illness (DUI) (p = 0.005), absence of lifetime psychotic symptoms (p = 0.025), presence of poly-substance use disorders (p = 0.033), comorbidity with obesity (p = 0.022), a last mood episode of manic polarity (p = 0.044), and lower bilirubin serum levels (p = 0.002); higher total cholesterol serum levels showed a trend toward statistical significance (p = 0.058). Conclusions: BD patients with lifetime suicide attempts present unfavorable clinical features. Some specific biochemical characteristics of bipolar patients may represent potential markers of suicidal behavior and need to be better investigated to identify new targets of treatment in the framework of personalized medicine. These preliminary findings have to be confirmed by further studies in different clinical settings.

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Section: Discussionmentioning

confidence: 99%

Which Clinical and Biochemical Parameters Are Associated with Lifetime Suicide Attempts in Bipolar Disorder?

et al. 2022

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“…An increase in tissue leptin can increase acute inflammatory response [72] and contribute to chronic inflammation in obesity [73]. Indeed, violent SA has been associated with abdominal obesity in BD individuals [74]. However, previous studies have also shown that plasma leptin levels are decreased in suicidal individuals compared to CON [75,76], suggesting that the exact role of this hormone in relation to suicidal behavior warrants further investigation.…”

Section: Discussionmentioning

confidence: 99%

Association between the Epigenetic Lifespan Predictor GrimAge and History of Suicide Attempt in Bipolar Disorder

Lima¹,

Kovács

Mirza

et al. 2022

Preprint

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Bipolar disorder (BD) has been previously associated with premature mortality and aging, including acceleration of epigenetic aging. Suicide attempts (SA) are greatly elevated in BD and are associated with decreased lifespan, biological aging, and poorer clinical outcomes. We investigated the relationship between GrimAge, an epigenetic clock trained on time-to-death and associated with mortality and lifespan, and SA in two independent cohorts of BD individuals (discovery cohort - controls (n=50), BD individuals with (n=77, BD/SA) and without (n=67, BD/non-SA) lifetime history of SA; replication cohort - BD/SA (n=48) and BD/non-SA (n=47)). An acceleration index for the GrimAge clock (GrimAgeAccel) was computed from blood DNA methylation (DNAm) and compared between groups with multiple general linear models. Differences in epigenetic aging from the discovery cohort were validated in the independent replication cohort. In the discovery cohort, controls, BD/non-SA, and BD/SA significantly differed on GrimAgeAccel (F=5.424, p=0.005), with the highest GrimAgeAccel in BD/SA (p=0.004, BD/SA vs. controls). Within the BD individuals, BD/non-SA and BD/SA differed on GrimAgeAccel in both cohorts (p=0.008) after covariate adjustment. Finally, DNAm-based surrogates revealed possible involvement of plasminogen activator inhibitor 1, leptin, and smoking pack-years in driving accelerated epigenetic aging. These findings pair with existing evidence that not only BD, but also SA, may be associated with an accelerated biological aging and provide putative biological mechanisms for morbidity and premature mortality in this population.

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Physical health comorbidities in older adults with bipolar disorder: A systematic review

Warner¹,

Holland²,

Lobban³

et al. 2023

Journal of Affective Disorders

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Violent suicide attempt history in elderly patients with bipolar disorder: The role of sex, abdominal obesity, and verbal memory: Results from the FACE-BD cohort (FondaMental Advanced center of Expertise for Bipolar Disorders)

Cited by 9 publications

References 87 publications

Which Clinical and Biochemical Parameters Are Associated with Lifetime Suicide Attempts in Bipolar Disorder?

Which Clinical and Biochemical Parameters Are Associated with Lifetime Suicide Attempts in Bipolar Disorder?

Association between the Epigenetic Lifespan Predictor GrimAge and History of Suicide Attempt in Bipolar Disorder

Physical health comorbidities in older adults with bipolar disorder: A systematic review

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