Viper venom neutralization by Indian medicinal plant (Hemidesmus indicus andPluchea indica) root extracts

Alam, Mohammad; Auddy, Biswajit; Gomes, Antony

doi:10.1002/(sici)1099-1573(199602)10:1<58::aid-ptr775>3.0.co;2-f

Cited by 49 publications

(27 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The toxicity of snake venom was assessed by injection of different concentration of venom in 0.2 ml physiological saline into tail vein of male albino mice 18 -20 gm [1]. To assess the in vitro antagonism, various concentrations of venom (1 -300 LD 50 ) were mixed with a fixed amount of plant extract (2 mg), the mixture incubated at 37˚C for 1h, and centrifuged at 2000 rpm for 10 min.…”

Section: Inhibition Of Venom Lethal Effectmentioning

confidence: 99%

“…The minimum clotting dose of plasma (MCDP) was determined as described by Alam et al [1]. Neutralization of this activity was estimated by mixing different amount of venom (1 -200 MCD), with a fixed amount of plant extract (100 µg), incubating for 1 h at 37˚C.…”

Section: Inhibition Of Venom Coagulant Activitymentioning

confidence: 99%

“…Many Indian medicinal plants/plant materials are recommended for the treatment of snakebite [2] [9] [10] and some are tested, but so far no systematic analysis has been done. In our earlier studies, it was showed that four of these plants ( Table 1), successfully neutralized the venom-induced pathophysiological changes [1] [2]. The present investigation attempts to identify those species, which are used in folk medicine in West Bengal, India and are worthy of further investigation as leads for drug development in management of snake bite.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Inhibition of Toxic Effects of Viper and Cobra Venom by Indian Medicinal Plants

Alam¹

2014

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Inhibition Of Venom Lethal Effectmentioning

confidence: 99%

Section: Inhibition Of Venom Coagulant Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Inhibition of Toxic Effects of Viper and Cobra Venom by Indian Medicinal Plants

Alam¹

2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…It has also been used in combination with other drugs for snake bite [43]. This plant has been used to treat against viper venom hemotoxic-induced lethality [44] and against hypercholesterolemia in hyperlipidemic rats [45]. However, sufficient scientific standards or parameters are not available to ascertain the identity and to determine the quality of this crude drug.…”

Section: H Indicusmentioning

confidence: 99%

2-Hydroxy-4-Methoxybenzaldehyde, an Astounding Food Flavoring Metabolite: A Review

Rathi¹,

Harwalkar²,

Jayashree³

et al. 2017

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: Rich endowment of traditional knowledge plays a critical role in health care, food security, culture, environment and development. Traditional knowledge is also widely used by the aromatic, flavoring, food and health industries. Plant-based traditional medicine has often been used to identify and fast-track the development of modern food and drugs. Plants synthesize such wide array of secondary metabolites that includes alkaloids, glucosinolates, terpenoids and phenylpropanoids. This study is aimed to review on indigenous and exotic medicinal plants containing an astounding food flavoring metabolite; 2-hydroxy-4-methoxybenzaldehyde (HMB). Material and Method:The review focuses on the isomer of vanillin, 2-hydroxy-4-methoxybenzaldehyde, also called MBALD, HMB, or 2H4MB, a flavor compound that is generally found in the roots and rhizomes of medicinal plants. This food flavoring phenylpropenoid is one of the least investigated isomers of vanillin. HMB is known to exhibit a wide array of medicinal properties. Though the molecular role of these metabolites remains largely unknown, they are known to play a key role in plant-environment interactions/stress response/defence signaling and application in pharmaceutical and nutraceutical industries. Discussion and Conclusion:One of the key secondary metabolites is the group of phenylproponoids synthesized either through shikimic acid pathway or the malonate/acetate pathway. Phenylalanine ammonia lyase (PAL) is the enzyme involved in phenylpropanoid pathway catalysing the deamination of phenylalanine to synthesize cinnamic acid that subsequently synthesizes variety of phenylpropanoid products. Inspite of its medicinal importance, the regulatory molecular mechanism underlying the biosynthetic pathway is largely unknown.

show abstract

“…There is a need for alternative therapeutics that can effectively neutralize RVV induced toxicities. From the present laboratory, many herbal antidotes have been identified against viper and cobra venom tested in animal models [5][6][7][8][9][10][11][12][13]. Recently, Gomes et al reported that efficacy of herbal compound against RVV was increased by gold nanoparticle conjugation [14].…”

Section: Introductionmentioning

confidence: 99%

Russell´s viper (Daboia Russelli Russelli) Venom Toxicity Neutralizing Efficacy of Curcumin- Gold Nanoparticle (C-GNP) in Experimental Animal Model

2016

J Toxins

View full text Add to dashboard Cite

Viper venom neutralization by Indian medicinal plant (Hemidesmus indicus andPluchea indica) root extracts

Cited by 49 publications

References 0 publications

Inhibition of Toxic Effects of Viper and Cobra Venom by Indian Medicinal Plants

Inhibition of Toxic Effects of Viper and Cobra Venom by Indian Medicinal Plants

2-Hydroxy-4-Methoxybenzaldehyde, an Astounding Food Flavoring Metabolite: A Review

Russell´s viper (Daboia Russelli Russelli) Venom Toxicity Neutralizing Efficacy of Curcumin- Gold Nanoparticle (C-GNP) in Experimental Animal Model

Contact Info

Product

Resources

About