Viral antibodies in recent onset, nonorganic psychoses: Correspondence with symptomatic severity

Srikanth, S. G.; Ravi, Vasanthapuram; Poornima, K.Shenoy; Shetty, K. Taranath; Gangadhar, Bangalore N.; Janakiramaiah, N.

doi:10.1016/0006-3223(94)90615-7

Cited by 35 publications

(22 citation statements)

References 9 publications

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“…Srikanth et al [24] investigated antibodies to 6 viruses (HSV-1, CMV, VZV, measles, mumps and JE viruses) in the blood and CSF of 35 psychotic patients including schizophrenia, mania and other psychoses. They found a significant change in the antibody titer in at least 10 (28.6%) patients during the course of their illness.…”

Section: Discussionmentioning

confidence: 99%

No Changes in Paired Viral Antibody Titers during the Course of Acute Schizophrenia

Fukuda¹,

Sasaki²,

Nanko³

1999

Neuropsychobiology

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Although there have been many studies surveying the prevalence of specific viral antibodies in a large cohort of patients with schizophrenia, changes in antibody levels during the course of acute illness have not been fully investigated. We conducted a preliminary study investigating levels of antibodies to 5 herpesviruses (herpes simplex virus type 1, cytomegalovirus, Epstein-Barr virus, varicella-zoster virus and human herpesvirus type 6) and 6 other viruses (measles, rubella, mumps, influenza A and B and Japanese encephalitis viruses) in paired sera of 8 patients with acute onset or exacerbation of schizophrenia. Assay for specific immunoglobulin M (IgM) antibody was also performed for herpesviruses and mumps. Neither any relevant change in antibody levels nor appearance of specific IgM antibody was observed for any of the viruses in any of the patients investigated. It is unlikely that the active infection or reactivation of these viruses has direct causal relationship to schizophrenia in these patients.

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Section: Discussionmentioning

confidence: 99%

No Changes in Paired Viral Antibody Titers during the Course of Acute Schizophrenia

Fukuda¹,

Sasaki²,

Nanko³

1999

Neuropsychobiology

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“…Other studies have noted higher numbers of these births during the periods of increased activity of infectious agents. 2 Herpes virus DNA has been identified in the brains of schizophrenia patients 3,4 and elevated antibody levels to herpes simplex virus (HSV) in schizophrenia patients in some, [5][6][7][8] but not all studies. [9][10][11] Among the infectious agents reported so far, herpes viruses are particularly interesting.…”

Section: Introductionmentioning

confidence: 99%

“…32 Increased symptom severity has also been associated with viral infections. 7 Thus, putative links between HSV1 and schizophrenia have been provided by epidemiologic, animal and postmortem studies. Examination of in vivo brain changes could provide important additional evidence and clarify links between these infections and pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

Brain morphological changes associated with exposure to HSV1 in first-episode schizophrenia

et al. 2006

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Infectious agents have been proposed as one of the risk factors for schizophrenia. However, the data on the association of infectious agents with in vivo brain changes are scant. We evaluated the association of serological evidence of exposure to herpes simplex virus 1 (HSV1) with in vivo brain structural variations among first-episode antipsychotic-naive schizophrenia/ schizoaffective disorder patients and control subjects. We assayed HSV1 immunoglobulin G (IgG) antibody in serum samples from 30 patients and 44 healthy subjects and obtained structural magnetic resonance imaging scans from the same individuals. There were proportionately more patients with elevated HSV1 antibody ratios than healthy comparison subjects (v 2 = 3.98, 1 df, P = 0.046) and patients had significantly higher HSV1 IgG antibody ratios compared with healthy subjects. Using optimized voxel-based morphometry, we examined diagnosis by HSV1 serological status interaction followed by within-and betweengroup comparison across the serological status. We observed a diagnosis by HSV1 serological status interaction and a significant main effect of HSV1 serological status in the prefrontal gray matter. Patients exposed to HSV1 had decreased gray matter in Brodmann area 9 (dorsolateral prefrontal cortex) and 32 (anterior cingulate cortex) compared with patients without serological evidence of exposure to HSV1. HSV1-associated differences in brain structure were not detected among healthy subjects. These findings suggest that HSV1 exposure in schizophrenia is associated with specific regional gray matter differences that may not be attributable to medications, illness chronicity or comorbid substance use. This study provides suggestive evidence for a link between HSV1 exposure and some of the cerebral morphological changes often reported in schizophrenia.

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“…Viral infections such as influenza, Epstein-Barr virus infection and the herpes simplex virus have been associated with psychotic symptoms. These studies have also found a relationship between the course of psychotic symptoms and changes in serum and CSF viral antibodies (Srikanth et al 1994). It was proposed by Lycke and Ziegler in 1983 that the stress of recent illness and fever may lead to reactivation of the latent virus, resulting in an acute and short-lived manifestation of psychotic symptoms.…”

Section: Concurrent Validatorsmentioning

confidence: 96%

Acute and Transient Psychosis: An Overview

Malhotra

Singh

2015

Developments in Psychiatry in India

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Viral antibodies in recent onset, nonorganic psychoses: Correspondence with symptomatic severity

Cited by 35 publications

References 9 publications

No Changes in Paired Viral Antibody Titers during the Course of Acute Schizophrenia

No Changes in Paired Viral Antibody Titers during the Course of Acute Schizophrenia

Brain morphological changes associated with exposure to HSV1 in first-episode schizophrenia

Acute and Transient Psychosis: An Overview

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