Viral Antibody Levels and Clinical Status in Acute Exacerbations of Chronic Bronchitis: a Controlled Prospective Study

Stenhouse, A. C.

doi:10.1136/bmj.3.5613.287

Cited by 26 publications

(10 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The finding in this study of rhinovirus infections in only 2.7% of exacerbations is considerably lower than the 23% recovery rate for rhinoviruses in exacerbations reported by Eadie [14,15]. Carilli et al, however, failed to isolate these agents [16].…”

Section: Discussioncontrasting

confidence: 75%

Infections with Viruses and Mycoplasma pneumoniae during Exacerbations of Chronic Bronchitis

Buscho¹,

Saxtan²,

Shultz³

et al. 1978

Journal of Infectious Diseases

102

View full text Add to dashboard Cite

The association of viral and Mycoplasma pneumoniae infections with acute exacerbations of chronic bronchitis was studied by serologic or isolation techniques in 46 adult men during the five years from 1964 through 1968. Serologic evidence of viral or M. pneumoniae infection was detected in 25% of 166 episodes of exacerbation and 14% of 138 remission periods (P = 0.02). Influenza A virus, parainfluenza virus type 3, and coronavirus OC43 predominated; infections with other viruses were infrequent. Infection with M. pneumoniae was detected serologically in four patients, but this organism was never isolated from sputum specimens. Rhinoviruses were isolated from frozen-stored sputum specimens in in 2.7% of the episodes of exacerbation and from 0.55% of the remission intervals (P not significant). These data suggest that although exacerbations of chronic bronchitis may be accompanied by viral and M. pneumoniae infections, patients with chronic bronchitis also acquire such infections without a worsening of their respiratory status.

show abstract

Section: Discussioncontrasting

confidence: 75%

Infections with Viruses and Mycoplasma pneumoniae during Exacerbations of Chronic Bronchitis

Buscho¹,

Saxtan²,

Shultz³

et al. 1978

Journal of Infectious Diseases

102

View full text Add to dashboard Cite

show abstract

“…Infection is felt to be a common cause of exacerbations of COPD, although comprehensive studies which employ sensitive viral diagnostic tests are lacking (14,36). Most of the published series to date have been small, and the percentage of illnesses caused by RSV in persons with COPD ranges widely, from 0 to 17.4% (14,17,36,75,112,113,162,164,170,180,192). In 1963, Carilli studied 30 subjects between the ages of 26 and 80 years who met the criteria for chronic bronchitis (17).…”

Section: Adults With Cardiopulmonary Conditionsmentioning

confidence: 99%

Respiratory Syncytial Virus Infection in Adults

2000

View full text Add to dashboard Cite

SUMMARY Respiratory syncytial virus (RSV) is now recognized as a significant problem in certain adult populations. These include the elderly, persons with cardiopulmonary diseases, and immunocompromised hosts. Epidemiological evidence indicates that the impact of RSV in older adults may be similar to that of nonpandemic influenza. In addition, RSV has been found to cause 2 to 5% of adult community-acquired pneumonias. Attack rates in nursing homes are approximately 5 to 10% per year, with significant rates of pneumonia (10 to 20%) and death (2 to 5%). Clinical features may be difficult to distinguish from those of influenza but include nasal congestion, cough, wheezing, and low-grade fever. Bone marrow transplant patients prior to marrow engraftment are at highest risk for pneumonia and death. Diagnosis of RSV infection in adults is difficult because viral culture and antigen detection are insensitive, presumably due to low viral titers in nasal secretions, but early bronchoscopy is valuable in immunosuppressed patients. Treatment of RSV in the elderly is largely supportive, whereas early therapy with ribavirin and intravenous gamma globulin is associated with improved survival in immunocompromised persons. An effective RSV vaccine has not yet been developed, and thus prevention of RSV infection is limited to standard infection control practices such as hand washing and the use of gowns and gloves.

show abstract

“…Long-term effects of influenza or other viral infections on the course of chronic obstructive pulmonary disease were not detected in this study population.The hypothesis that viral infections of the respiratory tract may contribute to progressive deterioration of airway function in patients with chronic bronchitis, emphysema, and other chronic obstructive pulmonary diseases (COPD) has intrigued investigators for several years [1][2][3][4][5]. Evidence supporting this hypothesis includes the well-documented association between viral infections and acute exacerbations of bronchitis in patients with COPD [5][6][7][8][9][10][11][12], as well as the recent reports that transient alterations in the function of small airways may occur in normal adults after acute viral infections of the respiratory tract [13][14][15][16][17][18][19].…”

mentioning

confidence: 99%

“…In a recent study of live attenuated vaccine for influenza virus, Zeck et al [20] reported that patients with COPD were more likely to develop transient deterioration of pulmonary function after infection than were normal adults. Unfortunately, except for the limited and inconclusive study of Stenhouse [6], there have been no adequate prospective studies of the associations between natural viral infections and changes in pulmonary function in patients with COPD.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Effect of Viral Infections on Pulmonary Function in Patients with Chronic Obstructive Pulmonary Diseases

Smith

Kanner

Golden

et al. 1980

Journal of Infectious Diseases

View full text Add to dashboard Cite

The effect of 100 separate viral infections of the respiratory tract on pulmonary function was evaluated prospectively over an eight-year period in 84 patients with chronic obstructive pulmonary diseases and in eight normal subjects. Some viral infections were associated with small acute declines in forced vital capacity and/or 1-sec forced expiratory volume of 25-300 ml. These declines were detectable only during the 90-day period after infection. The greatest abnormalities of pulmonary function followed infections with influenza virus, and the mean acute changes in 1-sec forced expiratory volume (-118.5 ml) were significantly greater than expected (-15.2 ml; P = 0.03). Smaller, statistically insignificant declines followed infections with parainfluenza virus, rhinovirus, adenovirus, and respiratory syncytial virus, and no changes were detectable after infections with coronavirus, herpes simplex virus, Mycoplasma pneumoniae, and Haemophilus influenzae. Long-term effects of influenza or other viral infections on the course of chronic obstructive pulmonary disease were not detected in this study population.

show abstract

Viral Antibody Levels and Clinical Status in Acute Exacerbations of Chronic Bronchitis: a Controlled Prospective Study

Cited by 26 publications

References 10 publications

Infections with Viruses and Mycoplasma pneumoniae during Exacerbations of Chronic Bronchitis

Infections with Viruses and Mycoplasma pneumoniae during Exacerbations of Chronic Bronchitis

Respiratory Syncytial Virus Infection in Adults

Effect of Viral Infections on Pulmonary Function in Patients with Chronic Obstructive Pulmonary Diseases

Contact Info

Product

Resources

About