Viral antibody studies in pancreatic disease.

Abstract

SUMMARY Viral studies were performed on sera from 54 patients with recent acute pancreatitis, 10 with recurrent acute pancreatitis, seven with chronic pancreatitis, and 10 with pancreatic carcinoma, and on sera from 81 age-and sex-matched controls. In 29 of the acute pancreatitis patients from whom paired sera were obtained no convincing evidence of recent viral infection was found. A higher incidence of raised antibody titres against Coxsackie B3 and B4 was observed in the group of acute pancreatitis patients compared with their controls. The possible significance of these observations and their relationship to the aetiology of the pancreatitis and to other immunological findings are discussed.

Coxsackie and mumpsvirus infection in a prospective study of acute pancreatitis.

“…However, we have noted a similar experience to that of other workers (Leinikki et al, 1973;Capner et al, 1975) regarding moderate CF titre rises to Coxsackie B and Mycoplasma pneumoniae occasionally occurring in acute pancreatitis patients. Therefore we support their contentions that a selective anamnestic response may be an accompaniment of acute pancreatitis or that pancreatic antigens (released during acute pancreatitis) may share common determinants with Coxsackie B and mycoplasma pneumoniae antigens.…”

“…Received for publication 6 August 1976 raised antibody titres to Coxsackie B are present in some patients with pancreatitis but the authors concluded that no case in their series was caused by acute viral infection (Capner et al, 1975). They suggest a selective anamnestic response, or low grade infection, or common determinants between pancreatic and Coxsackie antigens may explain their observations.…”

Severe Pancreatitis and Fatty Liver Progressing to Cirrhosis Associated with Coxsackie B4 Infection in a Three Year Old with Alpha‐1‐Antitrypsin Deficiency

“…Puncreatitis. Infection with Coxsackie viruses B3, B4, and B5 has previously been reported in acute pancreatitis (3,4). In this child the high titre of antibodies to Coxsackie B4 supported this diagnosis, although the absence of any early serum sample precluded demonstration of a rising titre.…”

Acute pancreatitis in hepatitis A infection

“…The viruses most frequently thought to be responsible are mumps virus (Feldstein et al, 1974;Naficy et al, 1973), Coxsackie B virus (Capner et al, 1975;Ursing, 1973;Tsui et al, 1972), Epstein-Barr virus (Wislocki, 1968), and measles virus (Bunnel & Monif, 1972). An association between viral hepatitis and acute pancreatitis has also been observed, although most of the patients concerned had fulminating hepatitis and the causal agent has been identified in only a very few patients (Archod, 1968;Parbhoo et al, 1973;Wands et al, 1973).…”