Viral detection using an embedded piezoresistive microcantilever sensor

Gunter, Robert L.; Delinger, W. G.; Manygoats, K.; Kooser, Ara; Porter, T. L.

doi:10.1016/s0924-4247(03)00379-0

Cited by 64 publications

(31 citation statements)

References 15 publications

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“…A humidity sensor is suggested in [71]. A field of growing interest is the detection of explosives [47], pathogens [72], nerve agents [73], viruses [74], bacteria, e.g., E. coli, [75], and pesticides such as dichlorodiphenyltrichloroethane (DDT) [76]. The issues of detection of environmental pollutants are discussed in [77].…”

Section: Recent Literature and Outlookmentioning

confidence: 99%

Microcantilever Sensors

Lang¹,

Gerber²

2008

Topics in Current Chemistry

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Microfabricated cantilevers have been used in atomic force microscopy for the topography imagingof non-conductive surfaces for more than 20 years. Cantilever beams without tips have proved theirapplicability in recent years as miniaturized, ultrasensitive, and fast-responding sensors for applicationsin chemistry, physics, biochemistry, and medicine. Microcantilever sensors respond by bending dueto the absorption of molecules. A shift in resonance frequency also occurs. They can be operatedin different environments such as gaseous environment, liquids, or vacuum. In gas, microcantileversensors can be operated as an artificial nose, whereby the bending pattern of a microfabricatedarray of eight polymer-coated silicon cantilevers is characteristic of the different vapors from solvents,flavors, and beverages. When operated in a liquid, microcantilever sensors are able to detectbiochemical reactions. Each cantilever is functionalized with a specific biochemical probe receptor,sensitive for detection of the corresponding target molecule. Applications lie in the fields of label-and amplification-free detection of DNA hybridization, the detection of proteins as well as antigen-antibodyreactions, and the detection of larger entities, such as bacteria and fungi.

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Section: Recent Literature and Outlookmentioning

confidence: 99%

Microcantilever Sensors

Lang¹,

Gerber²

2008

Topics in Current Chemistry

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“…This collector is ideally suited for integration with micro resonator devices operating in gaseous state, which provide higher sensitivities than in the liquid state due to lower viscous damping. These collectors can be promising candidates as real-time monitoring devices, which can be highly beneficial due to their short response times for a wide range of applications [4,8,9]. Fig.…”

Section: E-mail Address: Bashir@purdueedu (R Bashir)mentioning

confidence: 99%

Capture of airborne nanoparticles in swirling flows using non-uniform electrostatic fields for bio-sensor applications

Jang

Akin

Lim

et al. 2007

Sensors and Actuators B: Chemical

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Collection of biological particles is the first and critical step for any biological agent detection system. Towards our goal of capturing and detecting airborne biological entities in real time, here we investigate on the design of an electrostatic particle capture system. We report on the capture of airborne 100 nm diameter polystyrene nanoparticles as a model system, in swirling flows under non-uniform electrostatic fields with an electrospray aerosol generator and a homemade particle collector. The particle collector has five positive electrodes on the bottom and one large grounded electrode on the top. The nanoparticles coming into the collector were slowed down during their swirling and stayed in the collector long before leaving the collector. Silicon chips were placed on the bottom electrodes and the electrostatically captured particles were counted as a function of flow rates, electrode positions, bias voltages, and capture times by epifluorescent images and scanning electron micrographs (SEMs). Particles captured in the electrode at the center of the collector were much less than those on the surrounding four electrodes and 10-25% of the particles with negative charges entering the collector were captured on the bottom electrodes at a flow rate of 1.1 l/min and an applied potential of 2 kV. Particle capture increased with decreasing flow rates. We also simulated flow and electrical fields separately, and found the positional trends to be in good agreement with the measurements. This collector is well adaptable to integration with micro resonator devices and can be used for real-time monitoring of bioaerosols.

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“…We have used EPM sensors in a variety of sensing applications, including the sensing of animal presence, (6) hydrogen fl uoride gas, (7) organophosphate gases, (5,8,9) volatile organic compounds (VOCs), carbon monoxide gas, (10) hydrogen cyanide gas, (11) and others. (12)(13)(14)(15) …”

Section: Introductionmentioning

confidence: 99%

Detection of Chlorine Gas Using Embedded Piezoresistive Microcantilever Sensors

2010

Sensors and Materials

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Embedded piezoresistive microcantilever (EPM) sensors may be constructed for various sensing applications. In each application, a custom sensing material that responds volumetrically to the desired analyte is designed. Here, we constructed EPM sensors for chlorine gas (Cl 2 ) detection. The sensing materials used consisted of polymer matrices combined with NaI crystals. Sensors constructed from a silicone-based matrix exhibited the strongest response to Cl 2 , with detection limits in an outdoor exposure setting of approximately 20 ppm.

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Viral detection using an embedded piezoresistive microcantilever sensor

Cited by 64 publications

References 15 publications

Microcantilever Sensors

Microcantilever Sensors

Capture of airborne nanoparticles in swirling flows using non-uniform electrostatic fields for bio-sensor applications

Detection of Chlorine Gas Using Embedded Piezoresistive Microcantilever Sensors

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