Viral Diseases

Jacoby, Robert O.; Bhatt, P. N.; Jonas, A M

doi:10.1016/b978-0-12-074901-0.50018-6

Cited by 33 publications

(40 citation statements)

References 101 publications

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“…Occasional CF antibody titers have been reported in rats, but these have not been correlated with disease, pathology or virus isolations (9). There has been one report of intranuclear inclusions and typical adenovirus particles in the intestines ofimmunosuppressed rats (18), but the responsible agent was not isolated.…”

Section: Association Of Mad With An Outbreak Of Clinical Disease In mentioning

confidence: 97%

Comparative biological characterization of mouse adenovirus strains FL and K 87 and seroprevalence in laboratory rodents

Smith

Winograd

Burrage

1986

Archives of Virology

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SummaryThe growth, stability and seroprevalence in laboratory rodents of the two known strains of mouse adenovirus were compared. The FL strain of mouse adenovirus grew in both L 929 murine fibroblasts and in CMT-93 murine rectal carcinoma cells, whereas the K 87 strain grew only in CMT-93 cells. The bulk of the FL progeny virus was released from the host cells. K 87 virus was largely cell-associated. Both virus strains were stable at 37 ° C in liquid medium. The K 87 strain was completely inactivated after 5-15 minutes at 56 ° C, whereas FL infectivity was still detected after two hours at this temperature. Both virus strains were stable in the dessicated state for 14 days, although FL viability was more dependent on the presence of protein in the virus diluent. Seroepidemiologic data suggest that viruses antigenically related to mouse adenovirus are more prevalent among laboratory rats than among laboratory mice and that the virus(es) infecting rats differ from those infecting mice. Results of retrospective serologic testing suggest an association between mouse adenovirus and an outbreak of disease in a mouse breeding colony.

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Section: Association Of Mad With An Outbreak Of Clinical Disease In mentioning

confidence: 97%

Comparative biological characterization of mouse adenovirus strains FL and K 87 and seroprevalence in laboratory rodents

Smith

Winograd

Burrage

1986

Archives of Virology

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“…There have been scattered reports implicating adenovirus in naturMly occurring infections of rats (8,14), but the infecting agent has not been physically isolated. It is unclear whether rats sustain infection with mouse adenovirus or serologieally related but rat-specific virus(es).…”

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confidence: 98%

Factors influencing susceptibility of laboratory rodents to infection with mouse adenovirus strains K87 and FL

Smith

Barthold

1987

Archives of Virology

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“…This inflammation may persist following recovery from overt (Hunt, 1963;Jacoby, Bhatt & Jonas, 1975;Jacoby, Bhatt & Jonas, 1979) or subclinical (Eisen- The anti-aging action of hypophysectomy in hypothalamic obese rats: effects on collagen aging, age-associated proteinuria development and renal histopathology. brandt, Hubbard & Schmidt, 1982) disease states.…”

Section: Discussionmentioning

confidence: 99%

Exophthalmos in ageing rats with Harderian gland disease

Rothwell

Everitt

1986

Lab Anim

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SummaryExophthalmos was found in aged rats in several longevity studies. Four cases were due to malignant Harderian gland neoplasia whilst others were associated with severe Harderian gland inflammation, less severe inflammation being found in rats without exophthalmos. Keywords: Rats; Harderian gland; Exophthalmos; Corona virus infections; NeoplasmsDuring routine physical examinations of rats in several longevity studies, cases of exophthalmos associated with Harderian gland neoplasia and inflammation were detected. Because both exophthalmos and spontaneous Harderian gland neoplasms appear to be rare in rats (Squire et al., 1978; Altman & Goodman, 1979; Taradach & Greaves, 1984), we examined the Harderian gland of all rats in the colony which developed exophthalmos over a 2 year period. Materials and methodsThe animals in this study were out bred Wistar rats bred at the University of Sydney Animal House, Castle Hill. Rats were housed in stainless steel cages in an air-conditioned room at 27 ± 0·5°C, 50%-75% relative humidity, and were exposed to artificial fluorescent light for 12 h per day. They had free access to tap water and were fed a commercial rat food (Doust & Rabbidge, Sydney, Australia) of composition 53% carbohydrate, 20% protein, 3·2% fat, 3·5% fibre, 1·37% calcium, 0·98% phosphorus and 0·25% sodium, with a calorific value of 12·5 kJ/g.The rats were part of several longevity studies (Everitt, Wyndham & Barnard, 1983;Wyndham, Everitt & Everitt, 1983). Male rats either were hypophysectomized by an intra-aural technique and given 0·5 mg cortisone acetate (Roussel Pharmaceuticals, Sydney, Australia) per 100 g of bodyweight by subcutaneous injection once per week or were sham operated. Some sham-operated rats were given the same amount of food as that consumed by the hypophysectomized rats, which was about 40% of the ad libitum intake of intact rats. A group of intact, non-sham-operated female rats given food ad libitum were also observed. All rats were given individual physical examinations at monthly intervals. Details of the number of rats in each group and the age range in which exophthalmos was detected and the Harderian glands examined are given in Table 1.Affected rats were killed with ether and the contents of the orbit were removed and fixed in 10% buffered formol saline. Sections for histopathology were cut longitudinally through the eyeball and attached Harderian gland and were stained with haematoxylin and eosin (H&E).

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Viral Diseases

Cited by 33 publications

References 101 publications

Comparative biological characterization of mouse adenovirus strains FL and K 87 and seroprevalence in laboratory rodents

Comparative biological characterization of mouse adenovirus strains FL and K 87 and seroprevalence in laboratory rodents

Factors influencing susceptibility of laboratory rodents to infection with mouse adenovirus strains K87 and FL

Exophthalmos in ageing rats with Harderian gland disease

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