Viral Diseases of the Nervous System

Summary The three suspected cases of HSV encephalitis who still survive were reported. Case 1, a 8 months old girl, and case 2 of 8 years 11 months old girl were diagnosed with basis of clinical findings and clinical course, serological demonstration of greater than four‐fold rises in complement fixing antibody and non‐CRN antibody, significant rise in CRN antibody (CRN/non‐CRN) and tests which could rule out other common viral origin Case 3 was diagnosed by isolation of virus from C.S.F. obtained at intraventricular puncture and by a significant rise in antibody (CF antibody, non‐CRN and CRN antibody).

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Electron microscopic observations on the virus particles inHerpes simplexencephalitis

Roy

Wolman

1969

J Clin Pathol

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Cerebral cortex from eight fatal cases ofHerpes simplexencephalitis has been studied by electron microscopy. The diagnosis had been based on clinical findings, necropsy evidence of bitemporal necrosis, and histological confirmation of intranuclear inclusions with a lymphocytic inflammatory response, even though virus cultures were unsuccessful. Virus particles were seen predominantly in nuclei in six of these cases, utilizing tissue which had been preserved in formalin for up to four years or had been embedded in paraffin. Although demonstration of these particles is only indicative of the herpes group and not specifically ofHerpes simplex, electron microscopy of either biopsy or postmortem material may be a useful adjunct in making the diagnosis and can be accomplished before virological studies have been completed.

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Viral Diseases of the Nervous System

Cited by 5 publications

References 5 publications

Herpes Simplex Encephalitis Presenting With Catatonia

Herpes Simplex Encephalitis Presenting With Catatonia

Three Suspected Cases of Herpes Simplex Virus Encephalitis

Electron microscopic observations on the virus particles inHerpes simplexencephalitis

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