Viral Effect of Sars-Cov-2 on Male Infertility

Sapozhkova, Zh. Yu.

doi:10.14489/lcmp.2021.01.pp.008-013

Laboratornaya I Klinicheskaya Meditsina. Farmatsiya

2021

DOI: 10.14489/lcmp.2021.01.pp.008-013

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Viral Effect of Sars-Cov-2 on Male Infertility

Zh. Yu. Sapozhkova¹

Abstract: Clinical laboratory diagnostics of male infertility is an integral part of the diagnostic process in the field of reproductive medicine. Studies conducted during the pandemia of novel coronavirus infection (COVID-19) indicate that RNA of SARS-CoV-2 can be detected in the testes, and that the possibility of disrupting spermatogenesis and the viral impact on male reproductive health has been predicted.

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Cited by 2 publications

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Informativeness of Combined Human Semen Analysis on the Way to Clarify the Causes of Reproductive Dysfunction: Basic Semen Examination and Sperm Sediment Cytology (Ssc)

Sapozhkova

2023

Laboratornaya I Klinicheskaya Meditsina. Farmatsiya

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Aim. To analyze the informativeness of combined human semen analysis using a basic semen examination & SSC on the way to clarify the causes of reproductive dysfunction. Materials and methods. We examined 529 samples of semen sediment from men aged 18 – 59 years with infertility and male accessory gland infection (MAGI) between 2019 and 2022. Study was conducted in combination of two laboratory methods like ROSE (rapid onesite examination) which one of them is 1 – 'basic semen examination' and second one is 2 – 'SSC' (‘Basic semen examination+SSC’-ROSE). Results. 15.13 % of all of patients presented normozoospermia, 1.25 % of them have SSC-markers like bacteriospermia (SSC-mB «+»). Outcomes of SSC-reports clarify that 84.69 % of all men have the diagnostic significant SSC-findingsand different combination of it; 69.75 % of them were SSC-mB «+». ‘Normozoospermia’ and ‘SSC-mB’ are associated, thus, the frequency of SSC-mB in the presence of normozoospermia is recorded as follows. Conclusion. The combined approach ‘Basic semen examination+SSC’-ROSE, allows the doctors to exclude a missing in the laboratory algorithm for check-up in male with impaired reproductive function and identifying the causes of idiopathic infertility, the causes of which were mainly positioned as unspecified.

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Informativeness of Combined Human Semen Analysis on the Way to Clarify the Causes of Reproductive Dysfunction: Basic Semen Examination and Sperm Sediment Cytology (Ssc)

Sapozhkova

2023

Laboratornaya I Klinicheskaya Meditsina. Farmatsiya

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Male infertility along with the era of coronavirus infection SARS-CoV-2

Кульченко

Druzhinina

Myandina

2022

Issled. prakt. med. (Print)

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Russian and foreign epidemiological data suggest that males may have an increased risk of morbidity and mortality associated with COVID‑19. It is known that due to the high expression of ACE2 in spermatogonia, Leydig and Sertoli cells, the testicle, as an organ producing male germ cells, is a potential target for the COVID‑19 virus, which directly affects the reproductive health of men. To date, several factors of the influence of the SARS-CoV‑2 virus on the male reproductive system are known. To begin with, when infected, the virus has a direct damaging effect on the testicle itself with the provocation of orchitis. In addition to the previous statement, high body temperature during inflammation contributes to an increase in testicular temperature, which can lead to a deterioration in the quality of sperm. Furthermore, a pronounced inflammatory reaction promotes the circulation of a large number of cytokines and damage to the hemato-testicular barrier. Also, the increased activity of immunocytes leads to an imbalance of the antioxidant system of men, an increase in the level of reactive oxygen species and the formation of oxidative stress. In a Nutshell, Leydig cell dystrophy provokes the development of secondary hypogonadism. Thus, COVID‑19, like a “multifaceted Janus”, has a polysymptomatic manifestation, but at the same time has a multifactorial effect on the reproductive function of a man. All these factors of the impact of the SARS-CoV‑2 virus on the testicle must be considered when rehabilitating the patient. It should be kept in mind that the deterioration of sperm quality is observed both during the acute period of coronavirus infection and during recovery period. Therefore, laboratory evaluation of the ejaculate in dynamics and its correction is necessary for males, especially those who plan to realize their reproductive potential.Conclusion. COVID‑19 generally has a negative impact on spermatogenesis and male fertility. To date, the timing and degree of restoration of a man’s reproductive function after a coronavirus infection remains completely unknown. Therefore, both in the early and late rehabilitation period, men of reproductive age need the supervision of an andrologist.

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Viral Effect of Sars-Cov-2 on Male Infertility

Cited by 2 publications

References 26 publications

Informativeness of Combined Human Semen Analysis on the Way to Clarify the Causes of Reproductive Dysfunction: Basic Semen Examination and Sperm Sediment Cytology (Ssc)

Informativeness of Combined Human Semen Analysis on the Way to Clarify the Causes of Reproductive Dysfunction: Basic Semen Examination and Sperm Sediment Cytology (Ssc)

Male infertility along with the era of coronavirus infection SARS-CoV-2

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