Viral etiology of acute respiratory infections in children in Southern Iran

Halaji, Mehrdad; Hashempour, Tayebeh; Moayedi, Javad; Pouladfar, Gholamreza; Khansarinejad, Behzad; Khashei, Reza; Moattari, Afagh; Musavi, Zahra; Ghassabi, Farzaneh; Pirbonyeh, Neda

doi:10.1590/0037-8682-0249-2018

Cited by 11 publications

(8 citation statements)

References 14 publications

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“…As an important find, we had a high rate of RV/EV isolation, there is growing evidence that supports that this pathogen can contribute to significant respiratory disease and could be associated with morbidity, admission to the PICU, or need of mechanical ventilation ( 42 , 43 ). Unlike other studies, as a prospective study conducted in Madagascar that reports human metapneumovirus (HMPV) infection in about 14% of children with ARF, we didńt have any isolation of HMPV ( 39 ), but we found another type of coronavirus as NL63 and HKU1 in a low-rate proportion, demonstrating the diversity of acute respiratory infections pathogens and the variations in the viral circulation for each region. The viral isolation behavior was different between age groups, being higher in children under 5 years of age, mainly in infants (<2 years).…”

Section: Discussioncontrasting

confidence: 99%

Incidence, etiology, sociodemographic and clinical characterization of acute respiratory failure in pediatric patients at a high-altitude city: A multicenter cohort study

Muñoz

Haddad²,

Beltran³

et al. 2022

Front. Pediatr.

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BackgroundAcute respiratory failure is a life-threatening medical condition, associated with a variety of conditions and risk factors, including acute respiratory diseases which are a frequent cause of pediatric morbidity and mortality worldwide. In Colombia, the literature related to ARF is scarce.ObjectiveTo determine the incidence, causes, and sociodemographic and clinical characteristics of ARF in three hospitals in Bogota, a high-altitude city located in Colombia, during the COVID-19 pandemic.MethodsA multicenter prospective cohort study called the FARA cohort was developed between April 2020 – December 2021. Patients older than one month and younger than 18 years with respiratory distress who developed ARF were included.Results685 patients with respiratory distress were recruited in 21 months. The incidence density of ARF was found to be 41.7 cases per 100 person-day CI 95%, (37.3–47.7). The median age was 4.5 years.. Most of the patients consulted during the first 72 h after the onset of symptoms. Upon admission, 67.2% were potentially unstable. The most frequent pathologies were asthma, bronchiolitis, pneumonia, and sepsis. At admission, 75.6% of the patients required different oxygen delivery systems, 29,5% a low-flow oxygen system, 36,8% a high-flow oxygen system, and 9,28% invasive mechanical ventilation. SARS-COV-2, respiratory syncytial virus, rhinovirus/enterovirus, and adenovirus were the most frequently isolated viral agents. The coinfection cases were scarce.ConclusionsThis multicenter study, the FARA cohort, developed at 2,600 meters above sea level, shows the first data on incidence, etiology, sociodemographic and clinical characterization in a pediatric population with ARF that also concurs with the COVID-19 pandemic. These results, not only have implications for public health but also contribute to the scientific and epidemiological literature on a disease developed at a high altitude.

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Section: Discussioncontrasting

confidence: 99%

Incidence, etiology, sociodemographic and clinical characterization of acute respiratory failure in pediatric patients at a high-altitude city: A multicenter cohort study

Muñoz

Haddad²,

Beltran³

et al. 2022

Front. Pediatr.

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“…Males were more represented in our patients group (53 males and 31 females). Masculine gender predominance was also reported in other studies [12,13]. Basing on case investigation forms, several clinical signs were detected.…”

Section: Discussionsupporting

confidence: 79%

“…Our results agree with other investigations about all age groups from numerous countries. For instance, positive ARIs pathogens were reported in 65.1% of patients in Cameroon [10], in 65% of patients in north of Morocco [7], 61.6% in Sweden [16], and 59.6% in Iran [13]. Relatively lower rates of positive cases were reported in Italy with 41.7% [17], and in Peru (42.6%) [18].…”

Section: Discussionmentioning

confidence: 96%

Acute Respiratory Infections Epidemiology and Etiology in Hospitalized Moroccan Children under 15 Years

et al. 2020

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Introduction: Acute respiratory infections (ARIs) are serious infections with multiple etiologies. Viral etiology is mostly common worldwide, especially in pediatric patients.Materials and methods: This study aims to describe epidemiology and etiology of ARIs in Moroccan children under 15 years old, through patients’ clinical features analysis and genetic detection of pathogens within 84 patients admitted to Hassan II regional hospital of Agadir, Morocco, from September 2015 to September 2016. Detection of pathogens was carried out using Multiplex real-time reverse transcription polymerase chain reaction (rRT-PCR) with Fast Track Diagnostic kit respiratory pathogens 21 plus.Results: Results gave 61.9% of positive viral and bacterial infections and 19.23% of co-infections by at least two pathogens. Males were mainly infected and the respiratory syncytial virus (RSV) was the most common in 53.8% of patients. Children aged less than 2 years were the most infected by ARIs pathogens, and especially by RSV virus. Concerning seasonality pattern, all ARIs pathogens showed a seasonal spreading mainly in winter.Conclusion: This study summarizes a great insight about epidemiology and etiology of ARIs among children under 15 years in Morocco. We observed that ARIs constituted a real health problem in infancy and the viruses are the commonest cause.

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“…We found that 78% out of the 33,404 ILIs cases tested positive for at least one respiratory pathogen. Many other similar studies reported lower percentages, including Saudi Arabia (24% of 4611), Iran (59.6% of 156), Cameroon (65% of 365), and Philippines (43% of 1864) (Albogami et al, 2018;Njouom et al, 2012;Halaji et al, 2019;Otomaru et al, 2015). On the other hand, and in accordance with our current findings, a report on respiratory viruses among children (6 months-10 years) in eight countries (Australia, South East Asia, and Latin America) indicated a positivity rate of 79.6% (Taylor et al, 2017).…”

Section: Discussionmentioning

confidence: 90%

Molecular epidemiology of influenza, RSV, and other respiratory infections among children in Qatar: A six years report (2012–2017)

Al-Romaihi

Smatti

Al-Khatib

et al. 2020

International Journal of Infectious Diseases

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Background: Studies on the etiology of respiratory infections among children in Qatar and surrounding countries are limited. Objectives: To describe the prevalence and seasonality of RSV, influenza, and other respiratory pathogens among children in Qatar. Methods: We retrospectively collected and analyzed data of 33,404 children (<15 years) presented with influenza-like illness from 2012 to 2017. Results: At least one respiratory pathogen was detected in 26,138 (78%) of patients. Together, human rhinoviruses (HRV), respiratory syncytial virus (RSV), and influenza viruses comprised nearly two-thirds of all cases, affecting 24%, 19.7%, and 18.5%, respectively. A prevalence of 5-10% was recorded for adenovirus, parainfluenza viruses (PIVs), human bocavirus (HboV), and human coronaviruses (HCoVs). Human metapneumovirus (HMPV), enteroviruses, M. pneumonia, and parechovirus had prevalences below 5%. While RSV, influenza, and HMPV exhibited strong seasonal activity in the winter, HRV was active during low RSV and influenza circulation. The burden of RSV exceeds that of influenza among young age groups, whereas influenza correlated positively with age. Further, HRV, adenovirus, influenza, and RSV infection rates varied significantly between male and females. Conclusion: This comprehensive multi-year study provides insights into the etiology of ILI among children in Qatar, which represents the Gulf region. Our results reinforce the significance of active surveillance of respiratory pathogens to improve infection prevention and control strategies, particularly among children.

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Viral etiology of acute respiratory infections in children in Southern Iran

Cited by 11 publications

References 14 publications

Incidence, etiology, sociodemographic and clinical characterization of acute respiratory failure in pediatric patients at a high-altitude city: A multicenter cohort study

Incidence, etiology, sociodemographic and clinical characterization of acute respiratory failure in pediatric patients at a high-altitude city: A multicenter cohort study

Acute Respiratory Infections Epidemiology and Etiology in Hospitalized Moroccan Children under 15 Years

Molecular epidemiology of influenza, RSV, and other respiratory infections among children in Qatar: A six years report (2012–2017)

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