Viral Etiology of Acute Respiratory Infections With Cough in Infancy

Regamey, Nicolas; Kaiser, Laurent; Roiha, Hanna L.; Deffernez, Christelle; Kuehni, Claudia E.; Latzin, Philipp; Aebi, Christoph; Frey, Urs

doi:10.1097/inf.0b013e31815922c8

Cited by 128 publications

(106 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This observation was confirmed in two birth cohort studies, both in 197 unselected infants [47] and in 263 infants with risk factors for atopic sensitisation [48]. JACKSON et al [49] evaluating 289 newborns at risk for atopy up to the age of 6 yrs, found that moderate-to-severe RV wheezing illness was the most significant risk factor not only for the development of preschool wheezing at the age of 3 yrs, but also for the development of asthma at the age of 6 yrs.…”

Section: From Bronchiolitis To Wheezing Bronchitissupporting

confidence: 63%

Bronchiolitis in infants and wheeze in preschool children

Midulla

2011

breathe

View full text Add to dashboard Cite

show abstract

Section: From Bronchiolitis To Wheezing Bronchitissupporting

confidence: 63%

Bronchiolitis in infants and wheeze in preschool children

Midulla

2011

breathe

View full text Add to dashboard Cite

show abstract

“…Morbidity associated with viral pneumonia is particularly high in children [8]. Distinguishing viral from bacterial pneumonia is helpful in initiating appropriate care (using antiviral vs antibacterial agents) in a timely fashion.…”

Section: Discussionmentioning

confidence: 99%

“…Viruses are common pathogens associated with respiratory symptoms in children [7,8]. Morbidity associated with viral pneumonia is particularly high in children [8].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Radiological findings in 210 paediatric patients with viral pneumonia: a retrospective case study

Guo

Wang²,

Sheng³

et al. 2012

BJR

View full text Add to dashboard Cite

Objective: The objective of this study was to assess the radiological presentations of different types of viral pneumonia in children. Methods: Nasopharyngeal swab specimens and bronchial aspirate samples from children with acute respiratory infections were obtained and tested for influenza B, adenovirus, respiratory syncytial virus and parainfluenza (Types 1, 2 and 3) by direct immunofluorescence assay, or for influenza A (Subtype H1N1) by quantitative real-time polymerase chain reaction. The chest radiographs of the 210 confirmed cases of viral pneumonia were analysed retrospectively by two independent radiologists for the identification, characterisation and description of the distribution of imaging abnormalities. The cases were divided into six groups on the basis of confirmed causative viral agent, and radiographic findings were compared, analysed and presented. Results: The abnormal chest radiograph findings consisted of bilateral patchy areas of consolidation (n5133), interstitial lung disease (n533), diffuse areas of air space consolidation (n529) and lobar consolidation (n515). The abnormalities were distributed bilaterally in 195 cases and observed more frequently in the lower zones than in other regions. The radiological findings varied significantly among the six groups (p50.0050). Pairwise comparison showed significant difference between influenza A (H1N1) and adenovirus (p50.0031) only. Conclusion: The predominant radiological finding in paediatric viral pneumonia was bilateral patchy areas of consolidation. The radiological findings differed significantly only between adenovirus and influenza A pneumonia. The diagnosis of the specific causative organism requires laboratory confirmation.

show abstract

“…RVs are the most frequent pathogens detected during both upper and lower respiratory tract infections and are associated with a large spectrum of clinical outcomes in this age group [4,5]. In the very young, they are one of the leading agents of bronchiolitis, second only to respiratory syncytial virus (RSV), and in children aged .12 months of age they are predominant pathogens associated with wheezing episodes [6][7][8].…”

mentioning

confidence: 99%

Rhinoviruses: markers of, or causative for, recurrent wheeze and asthma?

Kieninger¹,

Regamey²

2012

Eur Respir J

View full text Add to dashboard Cite

R hinovirus (RV) infections occur early and recurrently in life and impose a large burden of disease in infants and young children [1][2][3]. RVs are the most frequent pathogens detected during both upper and lower respiratory tract infections and are associated with a large spectrum of clinical outcomes in this age group [4,5]. In the very young, they are one of the leading agents of bronchiolitis, second only to respiratory syncytial virus (RSV), and in children aged .12 months of age they are predominant pathogens associated with wheezing episodes [6][7][8]. In addition to their impact on short-term morbidity, RVs have been shown to represent an important pathogenic factor in the development of recurrent wheeze and asthma; a role which is yet not fully understood [9][10][11][12]. Several studies have been conducted over the past few years evaluating the influence of RV infections in early life on the development and incidence of wheezing and asthma [13][14][15][16][17]. They have clearly demonstrated that RV-associated wheezing is a risk factor for asthma development, and that approximately one third of infants with recurrent RV-induced wheezing illnesses go on to develop asthma. Unfortunately, most of these studies have been conducted in infants at high risk for atopy and asthma and not in unselected populations, or have included hospitalised children of a wide age range. These are significant limitations in the understanding of the respective influences of virus infections, atopy, age and maturity of the immune system on asthma development on a population level.In this issue of the European Respiratory Journal, MIDULLA et al.[18] present a prospective, single-centre study in which they assessed possible risk factors for recurrent wheezing during a 1-yr followup in .300 infants aged ,12 months hospitalised for their first episode of bronchiolitis. They found that RV-induced bronchiolitis (OR 3.3, 95% CI 1.0-11.1) and a positive family history for asthma (OR 2.5, 95% CI 1.2-4.9) were the strongest independent risk factors for recurrent wheezing and, therefore, concluded that a nasal washing positive for RV in infants hospitalised for bronchiolitis can possibly predict infants prone to the development of recurrent wheezing. These results concur well with a very recently published Finnish study in the European Respiratory Journal [19], in which children ,6 months of age hospitalised for bronchiolitis were followed at 6 yrs of age, demonstrating that the risk of asthma was lower after RSV bronchiolitis (8%) than after bronchiolitis caused by other viruses (24%). It will be interesting to see whether RVinduced bronchiolitis in the cohort of MIDULLA et al.[18] remains a risk factor for the development of asthma at school age.

show abstract

Viral Etiology of Acute Respiratory Infections With Cough in Infancy

Abstract: Rhinoviruses, coronaviruses, HMPV, and HBoV are common pathogens associated with respiratory symptoms in otherwise healthy infants. They should be considered in the differential diagnosis of the aetiology of ARI in this age group.

Cited by 128 publications

References 26 publications

Bronchiolitis in infants and wheeze in preschool children

Bronchiolitis in infants and wheeze in preschool children

Radiological findings in 210 paediatric patients with viral pneumonia: a retrospective case study

Rhinoviruses: markers of, or causative for, recurrent wheeze and asthma?

Contact Info

Product

Resources

About