Viral heart disease — treatment

Pawlak, Agnieszka; Gil, Katarzyna; Dörr, Marcus

doi:10.5603/kp.a2017.0141

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…This suggests that the virus spectrum of myocarditis may ; Table 5). b Expanded access in cases of B19V-associated cardiomyopathy with high replication and clinical impairment (New York Heart Association III and/or LVEF < 30%), individualized decision based on expert opinion and scientific proceedings publications; 45,46 600 mg telbivudine was given p.o. for 6 months.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic implications of a combined diagnostic workup including endomyocardial biopsy in an all‐comer population of patients with heart failure: a retrospective analysis

et al. 2018

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BackgroundAetiology of heart failure (HF) often remains obscure. We therefore evaluated the usefulness of a combined diagnostic approach including cardiac magnetic resonance imaging (CMRI) and endomyocardial biopsy (EMB) to assess the cause of unexplained cardiomyopathy underlying HF.Methods and resultsWe retrospectively investigated 100 consecutive patients (36% women, mean age 53.6 ± 18.8 years) presenting with unexplained cardiomyopathy (HF with reduced ejection fraction or left ventricular hypertrophy; excluding ischaemic and valvular heart disease; left ventricular ejection fraction 31.6 ± 13.9%, Left ventricular end‐diastolic pressure 18.2 ± 9.3 mmHg, heart rate 89 ± 26.6 b.p.m.; mean ± SEM) at the University Medical Center Mainz. We performed electrocardiography, echocardiography, CMRI, and cardiac catheterization with EMB analysed at a Food and Drug Administration‐approved reference centre in 100%, 94%, 69%, and 100% of patients, respectively. On the basis of CMRI findings, electrocardiography, echocardiography, and medical history, the exact cause of cardiomyopathy remained uncertain in 37 of 69 cases (53.6%). In EMB, 25% of patients had viral replication, 23% had inflammation defined as lymphocytic infiltrations without active virus replication, 1% had giant cell myocarditis, and 1% had eosinophilic myocarditis. After diagnostic workup including EMB findings, the cause of cardiomyopathy remained unidentified in 14% of the cases, classified as idiopathic dilated cardiomyopathy or hypertrophic cardiomyopathy in 10% or 4%, respectively. EMB helped to discuss a causal treatment strategy of HF involving immunosuppression or antiviral treatment in 53% of patients, which was opted for in 12% of the patients.ConclusionsA comprehensive workup including imaging and EMB in an all‐comer population of patients with HF may help physicians to improve diagnostics of unexplained cardiomyopathy in the majority of cases.

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Section: Discussionmentioning

confidence: 99%

Therapeutic implications of a combined diagnostic workup including endomyocardial biopsy in an all‐comer population of patients with heart failure: a retrospective analysis

et al. 2018

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“…The acute phase may also lead to death or severe dilated cardiomyopathy in 12% to 25% of cases. 84 The immune mechanism is the key contributor to myocardial damage due to myocarditis. The NK cells, which exert cardioprotective effect by inhibiting virus replication, are the first to reach the infected myocardium.…”

Section: Risk Factorsmentioning

confidence: 99%

Viruses in transplantology

Mucha¹,

Foroncewicz²,

Dębska‐Ślizień³

et al. 2019

Polish Archives of Internal Medicine

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PART I GENERAL OVERVIEW OF MAJOR VIRAL INFECTIONS 7 Cytomegalovirus 10 BK virus 14 Epstein-Barr virus 15 Influenza 16 Hepatitis C virus 17 HIV 21 Human papilloma virus PART II SPECIFIC ISSUES IN MANAGEMENT OF VIRAL INFECTIONS IN TRANSPLANT RECIPIENTS 23 Viruses versus myocarditis and acute coronary syndromes 24 Viruses and kidney transplant eligibility 25 Treatment of hepatitis B virus infection in transplant recipients 27 Viral infections in kidney and upper extremity transplant recipients 28 Histological diagnosis of BK virus and cytomegalovirus infections 29 Viral diarrhea 29 Ground glass opacification PART III COMMENTARY 35 The art of immunosuppression in liver transplantation: personal reflections based on a 40-year career

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