Viral hepatitis and HIV-associated tuberculosis: Risk factors and TB treatment outcomes in Thailand

Sirinak, Chawin; Kittikraisak, Wanitchaya; Pinjeesekikul, Duangporn; Charusuntonsri, Pricha; Luanloed, Phinai; Srisuwanvilai, La-Ong; Nateniyom, Sriprapa; Akksilp, Somsak; Likanonsakul, Sirirat; Sattayawuthipong, Wanchai; Burapat, Channawong; Varma, Jay K.

doi:10.1186/1471-2458-8-245

Cited by 30 publications

(28 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some of these associations, such as the use of illicit drugs (Sirinak et al 2008), history of incarceration (Richards et al 2006), and HIV infection (Reis et al 2011), have been observed previously in Asia and the Americas.…”

Section: Discussionmentioning

confidence: 95%

Prevalence of hepatitis C virus and human immunodeficiency virus in a group of patients newly diagnosed with active tuberculosis in Porto Alegre, Southern Brazil

Costi

Grandi

Halon

et al. 2017

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

BACKGROUND Porto Alegre is the Brazilian state capital with second highest incidence of tuberculosis (TB) and the highest proportion of people infected with human immunodeficiency virus (HIV) among patients with TB. Hepatitis C virus (HCV) infection increases the risk of anti-TB drug-induced hepatotoxicity, which may result in discontinuation of the therapy.OBJECTIVES The aim of this study was (i) to estimate prevalence of HCV and HIV in a group of patients newly diagnosed with active TB in a public reference hospital in Porto Alegre and (ii) to compare demographic, behavioural, and clinical characteristics of patients in relation to their HCV infection status.METHODS One hundred and thirty-eight patients with TB were tested for anti-HCV antibody, HCV RNA, and anti-HIV1/2 antibody markers. HCV RNA from real-time polymerase chain reaction (PCR)-positive samples was submitted to reverse transcription and PCR amplification. The 5′ non-coding region of the HCV genome was sequenced, and genotypes of HCV isolates were determined.FINDINGS Anti-HCV antibody, HCV RNA, and anti-HIV antibodies were detected in 27 [20%; 95% confidence interval (CI), 13-26%], 17 (12%; 95% CI, 7-18%), and 34 (25%; 95% CI, 17-32%) patients, respectively. HCV isolates belonged to genotypes 1 (n = 12) and 3 (n = 4). Some characteristics were significantly more frequent in patients infected with HCV. Among them, non-white individuals, alcoholics, users of illicit drugs, imprisoned individuals, and those with history of previous TB episode were more commonly infected with HCV (p < 0.05).MAIN CONCLUSIONS HCV screening, including detection of anti-HCV antibody and HCV RNA, will be important to improving the management of co-infected patients, given their increased risk of developing TB treatment-related hepatotoxicity.

show abstract

Section: Discussionmentioning

confidence: 95%

Prevalence of hepatitis C virus and human immunodeficiency virus in a group of patients newly diagnosed with active tuberculosis in Porto Alegre, Southern Brazil

Costi

Grandi

Halon

et al. 2017

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

show abstract

“…The major risk factors for triple infection of HIV-TB-Hepatitis were found to be having multiple sexual partners, followed by unsafe sexual intercourse (data not presented). This is probably due to shared routes of transmission of HIV and hepatitis (B&C), and TB is the opportunistic disease which comes after immune suppression like in HIV patients (Sterling and Sulkowski, 2004;Sy and Jamal, 2006;Solomon et al, 2008;Sirinak et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of triple viral infections of human immunodeficiency virus (HIV), hepatitis B and C among tuberculosis patients and associated risk factors: The case of West Arsi Zone, Ethiopia

Mengesha¹,

Airgecho²,

Negera³

et al. 2015

Afr. J. Microbiol. Res.

View full text Add to dashboard Cite

Tuberculosis, human immunodeficiency virus and hepatitis B and C infections are serious public health problems in Ethiopia. This study was conducted to assess the prevalence of triple viral infections and associated factors among tuberculosis patients who were on anti-tuberculosis treatment in the year 2011/12 in West Arsi Zone, Ethiopia. A cross sectional study design was conducted among 374 TB patients who were on first line anti-TB treatment. Simple random sampling technique was employed to draw the study subjects until the calculated sample size was achieved. Blood samples were collected to determine the HIV serostatus by rapid HIV testing kits; whereas the hepatitis B and C sero-status was determined by instant one step HBsAg and Flavicheck-HCV WB kits, respectively. Socio-demographic and risk factors information was collected and analysed using univariate and multivariate logistic regression. Injection drug users were excluded from this study. From a total of 374 tuberculosis patients enrolled, TB-HIV co-infection was found to be 56 (14.97%) among which 5 (8.92%) hepatitis B and 4 (7.14%) were hepatitis C triple infected. The overall TB-HIV-Hepatitis triple infection prevalence was 2.4% (9/374). Though the current level of triple viral infections among TB patients seems to be low, an integrated program for treatment, prevention and control strategy is crucial to be considered in TB patient management.

show abstract

“…However, certain studies disagree with this association, possibly because they were conducted with a small number of patients with the hepatitis B or C viruses 37,38,39,40 .…”

Section: Discussionmentioning

confidence: 99%

Hepatotoxicity induced by antituberculosis drugs among patients coinfected with HIV and tuberculosis

Lima

Melo

2012

Cad. Saúde Pública

View full text Add to dashboard Cite

Hepatotoxicity due to antituberculosis drugs limits treatment in patients coinfected with HIV and tuberculosis. We conducted a case-control study to identify risk factors for hepatotoxicity among patients coinfected with tuberculosis and HIV in two hospitals in Recife, Pernambuco State, Brazil. The sample consisted of 57 patients (36.5% of the total) who developed hepatotoxicity and a control group of 99 patients (63.5% of the total), who did not present this effect. Hepatotoxicity consisted of jaundice or a high concentration of AST/ALT or total bilirubinemia. Multivariate logistic regression showed that a T CD4+ count of < 200 cells/mm(3) increased the risk of hepatotoxicity by a factor of 1.233 (p < 0.001) and that coinfection with hepatitis B or C virus increased this risk by a factor of 18.187 (p = 0.029). Discharge occurred among 66.1% of the case group (p = 0.026). The absence of hepatotoxicity was a protective factor against death (OR = 0.42; 95%CI: 0.20-0.91). Coinfection with the B and C hepatitis virus and a T CD4+ cell count below 200 cells/mm(3) were independent risk factors for hepatotoxicity in these patients.

show abstract

Viral hepatitis and HIV-associated tuberculosis: Risk factors and TB treatment outcomes in Thailand

Cited by 30 publications

References 19 publications

Prevalence of hepatitis C virus and human immunodeficiency virus in a group of patients newly diagnosed with active tuberculosis in Porto Alegre, Southern Brazil

Prevalence of hepatitis C virus and human immunodeficiency virus in a group of patients newly diagnosed with active tuberculosis in Porto Alegre, Southern Brazil

Prevalence of triple viral infections of human immunodeficiency virus (HIV), hepatitis B and C among tuberculosis patients and associated risk factors: The case of West Arsi Zone, Ethiopia

Hepatotoxicity induced by antituberculosis drugs among patients coinfected with HIV and tuberculosis

Contact Info

Product

Resources

About