Viral hepatitis management in pregnancy: practical insights from a pediatric perspective

Rubino, Chiara; Stinco, Mariangela; Indolfi, Giuseppe

doi:10.21037/tgh-23-109

Transl Gastroenterol Hepatol

2024

DOI: 10.21037/tgh-23-109

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Viral hepatitis management in pregnancy: practical insights from a pediatric perspective

Chiara Rubino,

Mariangela Stinco,

Giuseppe Indolfi

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2024

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Hepatitis co-infection in paediatric HIV: progressing treatment and prevention

Rubino,

Stinco,

Indolfi

2024

Current Opinion in HIV and AIDS

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Purpose of review To analyse the main evidence and recommendations for the management of hepatitis co-infection in children living with HIV. Recent findings We analysed available data pertaining to the natural history of liver disease and treatment of co-infected children. Summary Viral hepatitis co-infection in people living with HIV (PLHIV) is a global problem owing to the shared routes of transmission, particularly in areas of high endemicity for the three viruses. Viral hepatitis co-infection can accelerate liver disease progression and increase morbidity and mortality, even in patients on suppressive antiretroviral treatment (ART). Viral hepatitis should be routinely screened in PLHIV and, once diagnosed with viral hepatitis, PLHIV should be closely monitored for liver disease progression and complications. Children living with HIV-HBV co-infection should be treated with ART containing agents which are active against both viruses. Children living with HIV-HCV co-infection should receive directly acting antivirals (DAA) to eradicate HCV infection. Prevention measures to reduce vertical and horizontal transmission of HBV and HCV (anti-HBV vaccination and immunoglobulins, anti-HBV treatment in pregnancy, anti-HCV DAAs in people of childbearing age, avoiding blood contact, sexual barrier precautions) should be adopted and encouraged, particularly in high endemicity countries.

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Hepatitis co-infection in paediatric HIV: progressing treatment and prevention

Rubino,

Stinco,

Indolfi

2024

Current Opinion in HIV and AIDS

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Viral hepatitis management in pregnancy: practical insights from a pediatric perspective

Cited by 1 publication

References 20 publications

Hepatitis co-infection in paediatric HIV: progressing treatment and prevention

Hepatitis co-infection in paediatric HIV: progressing treatment and prevention

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