2014
DOI: 10.6026/97320630010726
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Viral Immune Evasion in Dengue: Toward Evidence-Based Revisions of Clinical Practice Guidelines

Abstract: Dengue, a leading cause of illness and death in the tropics and subtropics since the 1950׳s, is fast spreading in the Western hemisphere. Over 30% of the world׳s population is at risk for the mosquitoes that transmit any one of four related Dengue viruses (DENV). Infection induces lifetime protection to a particular serotype, but successive exposure to a different DENV increases the likelihood of severe form of dengue fever (DF), dengue hemorrhagic fever (DHF), or dengue shock syndrome (DSS). Prompt support… Show more

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Cited by 20 publications
(18 citation statements)
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“…The response of interferon or cytokines to dengue infection was part of the innate immunity initiated at day 0-1 following dENV infection, and declines 3-4 days thereafter. The upregulation of these early innate immune responses coincides, as it should from an immune surveillance perspective, with a drop in dENV viral replication during days 0-3 of the fever (35). A variation in the impairment of the function of type 1 interferon, either at the level of its receptor or by interfering with its signaling pathway (JAK-STAT) may cause variations in the clinical course of the disease.…”
Section: Discussionmentioning
confidence: 80%
“…The response of interferon or cytokines to dengue infection was part of the innate immunity initiated at day 0-1 following dENV infection, and declines 3-4 days thereafter. The upregulation of these early innate immune responses coincides, as it should from an immune surveillance perspective, with a drop in dENV viral replication during days 0-3 of the fever (35). A variation in the impairment of the function of type 1 interferon, either at the level of its receptor or by interfering with its signaling pathway (JAK-STAT) may cause variations in the clinical course of the disease.…”
Section: Discussionmentioning
confidence: 80%
“…It is possible and even probable that this hypothetical model will also contribute to the elucidation of the pathological mechanisms that underlie Zika virus infection. Proof of principle is given in our recent discussion of neuroendocrineimmune interactions in Dengue [ 29 ]. Zika and Dengue are members of the genus Flavivirus, which also includes the West Nile virus, the tick-borne encephalitis virus, the Chikungunya virus, the Yellow Fever virus, and contribute to the incidence of and morbidity of encephalitis, among other pathologies.…”
Section: Discussionmentioning
confidence: 99%
“…In brief, the inflammatory response is composed of two phases: the first, triggered and sustained by myeloid CD45+CD14+ cells (some of which are CD4+dim) that produce interleukin (IL)6, IL1b and tumor necrosis factor (TNF)a in addition to prostaglandins and other non-cytokines that favor inflammatory processes - this is a rather sharp and short-lived response; and the second, triggered by lymphoid CD45+CD14- cells (many of which are CD4+high) that engender a TH17 response (i.e., predominant cytokines: IL17 and IL23), which is finely regulated by IL9 and other TH9 cytokines representatives - this, by contrast, is a sustained inflammation, such as that we observe in inflammatory diseases (e.g., inflammatory bowel disease). Both arms are subject to fine regulation brought up in part by regulatory T cells (CD4+CD25+FoxP3+) [ 12 , 13 ]. One important gap in knowledge in the immuno-pathology of IRIS is the characterization, within the fast rising CD4 cell population, of which subpopulation of CD4+ cell is fast proliferating, and of whether or not the rise in cell number corresponds to increased specific functional responses.…”
Section: Introductionmentioning
confidence: 99%
“…With that expansion of the tropical zones, mosquito-borne diseases spread wider and faster into heavily inhabited cities. Novel infectious diseases, including Ebola [ 6 ], Zika [ 7 ] and others [ 8 ] pose new challenges to public health and health care in Western societies. When making the case for patient-centered care [ 1 ] in this context, it behooves us to take into serious consideration the important role of the individual allostatic responses of each individual patient to the climatic macroenvironmental stressors discussed above.…”
Section: Bioinformation For Termentioning
confidence: 99%