Viral infections associated with Kawasaki disease

Yıldırım, Deniz Gezgin; Demirdağ, Tuğba Bedir; Tokgöz, Semiha Terlemez; Tapisiz, Anıl; Bakkaloğlu, Sevcan A.; Buyan, Necla

doi:10.5152/turkarchpediatr.2021.20250

Cited by 2 publications

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“… 27 Importantly, KD could be triggered by various infectious agents in genetically susceptible individuals. 28 Still, the role of PRDM15 and ZNF112 in the immune response to infections has never been studied. Therefore, further studies are needed before we understand the mechanistic role of polymorphisms in PRDM15 and ZNF112 on HEV antibody response.…”

Section: Discussionmentioning

confidence: 99%

Genome-wide association study identifies several loci for HEV seropositivity

Smatti¹,

Al-Sarraj²,

Yassine³

2023

iScience

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Section: Discussionmentioning

confidence: 99%

Genome-wide association study identifies several loci for HEV seropositivity

Smatti¹,

Al-Sarraj²,

Yassine³

2023

iScience

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Kawasaki disease in Malaysia: Biochemical profile, characterization, diagnosis and treatment

et al. 2023

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IntroductionKawasaki disease (KD) is an acute idiopathic systemic vasculitis with a self- limiting course that predominantly affects children under 5 years old, particularly in the East Asian countries. Nevertheless, to date, the data on KD in Malaysia are limited. This study aimed to evaluate the epidemiology, clinical features, treatment, and outcomes of KD among the pediatric patients admitted to Hospital Canselor Tunku Muhriz (HCTM), Kuala Lumpur, Malaysia.MethodA retrospective cohort study of 66,500 pediatric patients presented at HCTM from the year 2004 to 2021 was conducted.Results62 KD cases out of 66,500 pediatric admissions were reported, with a male-to-female ratio of 1.58 to 1. Majority of KD patients (95.0%) were younger than 5 years old. Prior infection was reported in 5 KD patients (8.1%). Apart from the classical features, manifestations of various organ systems including cardiovascular (16.1%), gastrointestinal (43.5%), neurological (1.61%), musculoskeletal (1.61%), and genitourinary (17.7%) systems were observed. There was a significant association between sterile pyuria and coronary artery aneurysm (CAA) (p < 0.05). Interestingly, abnormal liver parameters (p < 0.05) and incomplete KD (p < 0.05) were significantly related to IVIG resistance.DiscussionThe presence of family history, immunological disorder, and previous infection in our KD patients suggested that there is a possibility of genetic, immunological, and infectious roles in the pathophysiology of KD. IVIG resistance is more likely to occur in KD patients with hepatic dysfunction or incomplete KD presentation. These findings highlighted the significant contribution of laboratory parameters to the prognosis of KD, prompting more in-depth research on the KD scoring systems and their relevance in this country.

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Viral infections associated with Kawasaki disease

Cited by 2 publications

References 0 publications

Genome-wide association study identifies several loci for HEV seropositivity

Genome-wide association study identifies several loci for HEV seropositivity

Kawasaki disease in Malaysia: Biochemical profile, characterization, diagnosis and treatment

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