Viral infections in the ICU

Luyt, Charles Edouard; Combes, Alain; Nieszkowska, Ania; Trouillet, J.; Chastre, Jean

doi:10.1097/mcc.0b013e32830f1e12

Cited by 47 publications

(46 citation statements)

References 40 publications

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“…Furthermore, HSV-2 was not detected in any of the patients. In comparison to previous reports that estimated lower prevalence of HHVs at the intensive care unit (ICU) (less than 5%) (37)(38)(39), there was a notably greater prevalence of HHVs at the PICU in our study.…”

Section: Discussioncontrasting

confidence: 54%

Prevalence of Human Herpes Viruses in Bronchoalveolar Lavage of Critically Ill Children Undergoing Mechanical Ventilation at a Pediatric Intensive Care Unit

Amanati

Karimi

Fahimzad

et al. 2018

Arch Pediatr Infect Dis

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Background: Critically ill children at the intensive care unit frequently develop hospital-acquired pneumonia (HAP). Human herpes viruses (HHVs), primarily or by reactivation may cause bronchopneumonitis in mechanically ventilated patients. The exact prevalence and role of HHVs in morbidity and mortality of pediatric patients undergoing mechanical ventilation is unclear. The current study was conducted to evaluate the prevalence of 5 Herpes viruses by polymerase chain reaction (PCR) method in bronchoalveolar lavage (BAL) samples in critically ill children at a pediatric intensive care unit (PICU). Methods: Overall, 140 bronchoalveolar lavage samples from 83 mechanically ventilated cases were studied. Samples were taken via the mini-BAL technique. Samples were analyzed by qualitative PCR for detection of herpes simplex virus type 1 and 2 (HSV1/HSV2), human herpes virus type 6 and 7 (HHV6/HHV7), Ebstein-Barr virus (EBV), and cytomegalovirus (CMV).

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Section: Discussioncontrasting

confidence: 54%

Prevalence of Human Herpes Viruses in Bronchoalveolar Lavage of Critically Ill Children Undergoing Mechanical Ventilation at a Pediatric Intensive Care Unit

Amanati

Karimi

Fahimzad

et al. 2018

Arch Pediatr Infect Dis

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“…Typically viral infections leading to respiratory failure in the ICU are separated as community acquired and nosocomial (30). …”

Section: Other Viruses Leading To Ardsmentioning

confidence: 99%

Viral Infection in the Development and Progression of Pediatric Acute Respiratory Distress Syndrome

2016

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Viral infections are an important cause of pediatric acute respiratory distress syndrome (ARDS). Numerous viruses, including respiratory syncytial virus (RSV) and influenza A (H1N1) virus, have been implicated in the progression of pneumonia to ARDS; yet the incidence of progression is unknown. Despite acute and chronic morbidity associated with respiratory viral infections, particularly in “at risk” populations, treatment options are limited. Thus, with few exceptions, care is symptomatic. In addition, mortality rates for viral-related ARDS have yet to be determined. This review outlines what is known about ARDS secondary to viral infections including the epidemiology, the pathophysiology, and diagnosis. In addition, emerging treatment options to prevent infection, and to decrease disease burden will be outlined. We focused on RSV and influenza A (H1N1) viral-induced ARDS, as these are the most common viruses leading to pediatric ARDS, and have specific prophylactic and definitive treatment options.

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“…Recent reports indicate that viral pathogens (eg, herpes simplex virus, cytomegalovirus, and mimivirus) may have a role as etiologic agents of VAP [13,14]. Further study is needed to identify the role of viral pathogens in HAP.…”

Section: Etiologymentioning

confidence: 98%

Severe hospital-acquired pneumonia: A review for clinicians

Dallas¹,

Kollef

2009

Curr Infect Dis Rep

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Hospital-acquired pneumonia (HAP) is one of the most commonly encountered nosocomial infections. Patients who develop severe HAP experience considerable morbidity and mortality, and the condition results in a substantial expenditure of health care resources. A large body of scientific literature about HAP now exists. This article summarizes the current state of knowledge concerning severe HAP with an emphasis on recent advances in its diagnosis, treatment, and prevention.

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Viral infections in the ICU

Cited by 47 publications

References 40 publications

Prevalence of Human Herpes Viruses in Bronchoalveolar Lavage of Critically Ill Children Undergoing Mechanical Ventilation at a Pediatric Intensive Care Unit

Prevalence of Human Herpes Viruses in Bronchoalveolar Lavage of Critically Ill Children Undergoing Mechanical Ventilation at a Pediatric Intensive Care Unit

Viral Infection in the Development and Progression of Pediatric Acute Respiratory Distress Syndrome

Severe hospital-acquired pneumonia: A review for clinicians

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