Viral Interferon Regulatory Factor 1 of Kaposi's Sarcoma-Associated Herpesvirus Binds to p53 and Represses p53-Dependent Transcription and Apoptosis

Seo, Taegun; Park, Junsoo; Lee, Daeyoup; Hwang, Sun Gwan; Choe, Joonho

doi:10.1128/jvi.75.13.6193-6198.2001

Cited by 106 publications

(88 citation statements)

References 25 publications

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“…21 LANA-1, which is constitutively expressed in tumor PEL cells, is able to suppress TP53 function and to induce β-catenin accumulation by trapping the glycogen synthase kinase-3b (GSK-3b) into the nucleus.…”

Section: Resultsmentioning

confidence: 99%

Mutational analysis of TP53, PTEN, PIK3CA and CTNNB1/ -catenin genes in human herpesvirus 8-associated primary effusion lymphoma

Boulanger¹,

Marchio²,

Hong³

et al. 2009

Haematologica

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Section: Resultsmentioning

confidence: 99%

Mutational analysis of TP53, PTEN, PIK3CA and CTNNB1/ -catenin genes in human herpesvirus 8-associated primary effusion lymphoma

Boulanger¹,

Marchio²,

Hong³

et al. 2009

Haematologica

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“…In addition, vIRF-1 is able to transform cells in culture which are then able to form tumours in nude mice (Gao et al, 1997). It exerts anti-apoptotic properties through transcriptional repression (Kirchhoff et al, 2002) and by binding to the p53 tumour suppressor (Nakamura et al, 2001;Seo et al, 2001) and a cell death regulator, GRIM19 (Seo et al, 2002). Burysek et al (1999b) carried out initial studies on an ORF of 163 codons that was subsequently identified as the first exon of vIRF-2.…”

Section: Introductionmentioning

confidence: 99%

Transcription mapping of human herpesvirus 8 genes encoding viral interferon regulatory factors

Cunningham

Barnard

Blackbourn

et al. 2003

Journal of General Virology

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The human herpesvirus 8 (HHV-8) genome contains four tandemly arranged genes encoding viral interferon regulatory factors (vIRF-1 to 4) located between genes 57 and 58. Transcript mapping techniques were employed to determine the sizes, ends and splicing patterns of mRNAs specified by these genes in HHV-8-infected cell lines untreated or chemically induced into the lytic growth cycle. Depending on the cell line used, vIRF-3 transcription was minimally or not induced (i.e. expressed with latent kinetics), whereas the other vIRFs were inducible (i.e. expressed with lytic kinetics). Each gene possessed its own promoter (or promoters) and polyadenylation sites, and all but vIRF-1 were spliced from two exons. vIRF-1 was transcribed in uninduced and induced cells from a single initiation site preceded by a TATA box, with the possible use of an additional TATA box and initiation site in uninduced cells. In induced cells, vIRF-2 was transcribed from a single major initiation site preceded by a TATA box, and vIRF-4 was expressed from two sites each preceded by a TATA box. Transcripts for these genes were insufficiently abundant in uninduced cells to map the 59-ends. vIRF-3 lacks an obvious TATA box and exhibited heterogeneous 59-ends in uninduced and induced cells. These data clarify and extend our understanding of the structure and transcription of the HHV-8 vIRF genes. INTRODUCTIONGenome sequences have been published for two strains of human herpesvirus 8 [HHV-8; also known as Kaposi's sarcoma-associated herpesvirus (KSHV)] by Russo et al. (1996) (accession no. U75698) and Neipel et al. (1997) (U93872). In addition to genes that are common to the members of the genus Rhadinovirus, several genes are unique to HHV-8 or found only in closely related species (for reviews, see Schulz, 1998;. A cluster of such genes is located in a 10 kbp region between open reading frames (ORFs) 57 and 58. Russo et al. (1996) described this region as containing an ORF (K9) whose encoded protein is related to cellular interferon regulatory factors (IRFs), plus two other protein-coding regions (K10 and K11), as illustrated in the upper part of Fig. 1. Other regions bearing amino acid similarity to IRFs were also noted, two upstream from K10 and one upstream from K11. Neipel et al. (1997) identified another ORF between K10 and K11, termed K10.1 (or K10.5), which corresponds closely to one of the IRF-like regions identified by Russo et al. (1996). Data from several groups subsequently indicated that this region of the genome contains four vIRF genes, one unspliced (vIRF-1 from K9) and three spliced (vIRF-2 from K11, vIRF-3 from K10.5 and vIRF4 from K10), as illustrated in the lower part of Fig. 1. The vIRF genes presumably arose by capture of cellular sequences followed by gene duplication events. The only other herpesvirus known to possess vIRFs is rhesus rhadinovirus (RRV), a close relative of HHV-8 (Searles et al., 1999;Alexander et al., 2000). RRV possesses eight tandem vIRFs, none of which appears to be spliced.Expression of HHV-8 genes is...

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“…For example, the KSHV gene ORF K9 encodes viral interferon regulatory factors 1 (vIRF-1) which is a protein with low but significant homology to members of the interferon (IFN) regulatory factor (IRF) family responsible for regulating intracellular IFN signal transduction (Moore et al 1996). The vIRF-1 functions as a repressor of IFN and IRF1-mediated signal transduction and also acts as an oncogene to induce cellular transformation (Seo et al 2001). Besides, it can modulate the transcription of the IFNA genes according to direct heterodimerization with members of the IRF family, and by competitive binding with cellular transcription factors to the carboxy-terminal region of p300, which could also bind IRF-3 and IRF-1 (Seo et al 2001;Burýsek et al 1999).…”

Section: Introductionmentioning

confidence: 99%

“…The vIRF-1 functions as a repressor of IFN and IRF1-mediated signal transduction and also acts as an oncogene to induce cellular transformation (Seo et al 2001). Besides, it can modulate the transcription of the IFNA genes according to direct heterodimerization with members of the IRF family, and by competitive binding with cellular transcription factors to the carboxy-terminal region of p300, which could also bind IRF-3 and IRF-1 (Seo et al 2001;Burýsek et al 1999). Moreover, a study showed that the EBV protein called latent infection membrane protein 1 (LMP1) can act as a constitutively active receptor that mimics activated CD40, which is a member of the tumor necrosis factor receptor family (Mosialos et al 1995).…”

Section: Introductionmentioning

confidence: 99%

Virus proteins similar to human proteins as possible disturbance on human pathways

2014

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Cancer is not rare anywhere in the world now, and the global burden of cancer continues to increase largely every year. Previous research on infections and cancers reported that, about 17.8 % of the cancers worldwide, which are over 1.9 million cases of cancer, are related to viral infections. At least six oncoviruses, cancer-causing viruses, have been known so far, which include hepatitis B virus, hepatitis C virus, Epstein-Barr virus (EBV or HHV-4), human papillomavirus, human T lymphotropic virus type 1, Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8), but the pathogenic mechanism is far from being completely understood. In this study, assuming that finding human proteins significantly similar to viral oncoproteins leads to a categorization of the cancer-related pathways that are currently not clearly known, we analyzed different types of virus-caused cancers based on their similarity in order to clarify the unknown cancer mechanisms. As a result, we obtained several potential tumor pathways that may be significant and essential in oncogenic cancer process, which will be helpful for further study on cancer mechanisms and the development of new drug targets.

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Viral Interferon Regulatory Factor 1 of Kaposi's Sarcoma-Associated Herpesvirus Binds to p53 and Represses p53-Dependent Transcription and Apoptosis

Cited by 106 publications

References 25 publications

Mutational analysis of TP53, PTEN, PIK3CA and CTNNB1/ -catenin genes in human herpesvirus 8-associated primary effusion lymphoma

Mutational analysis of TP53, PTEN, PIK3CA and CTNNB1/ -catenin genes in human herpesvirus 8-associated primary effusion lymphoma

Transcription mapping of human herpesvirus 8 genes encoding viral interferon regulatory factors

Virus proteins similar to human proteins as possible disturbance on human pathways

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