Viral Papillomatosis

Sykes, Jane E.; Luff, Jennifer

doi:10.1016/b978-1-4377-0795-3.00026-0

Cited by 3 publications

(3 citation statements)

References 42 publications

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“…Five of the dogs examined in the study were younger than 8 months, and one dog was 16 years old.CPV infection is more common in young dogs and no breed or gender related susceptibility has been previously reported by most (Christian and Claude, 2011;Lange et al, 2011;Sykes and Luff, 2014) accept Bianchi et al (2012). Interestingly, five dogs were mixed breed and younger than 8 months old in the present study (Table1).…”

Section: Discussionmentioning

confidence: 95%

Electron microscopy and histopathological examination of canine papilomavirus

Tekelioğlu¹

2022

Journal of Istanbul Veterinary Sciences

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Diagnosis of canine papillomavirus (CPV) infection by histopathology, transmission and scanning electron microscopy is presented. The study is based on data obtained by examining nonregressing papillomas (warts) from naturally infected dogs with clinical manifestations of CPV infection. Papules on the mouth and lips were common bilaterally in all dogs. Confirmatory diagnosis of sick dogs was made by clinical findings, histopathology, transmission and scanning electron microscopy. Histopathological examination of hematoxylin and eosin stained papillomas revealed lymphoplasmocytic cell infiltration and fibrosis, parakeratosis in the dermis, papillary proliferation and intranuclear vacuole degeneration in the stratum spinosum. Electron microscopy demonstrated viral icosahedral capsid formation and non-enveloped viral structure of CPV. Transmission electron microscopy demonstrated viral particles and virions in the nuclei of infected cells, viral crystal mode formation in the nucleus. Scanning electron microscopy demonstrated virions and virus-like particles budding in the infected tissue. The findings of the study reveal that electron microscopy and histopathology are effective and sensitive methods in the diagnosis of CPV infection. Electron microscopy is the only imaging technique that allows direct visualization of viruses, along with affected tissues and cells, due to its nanometer-scale resolution. This study reveals the intracellular and extracellular viral pathogenesis, viral ultra structure and structural components of CPV. Present findings indicate canine papillomavirus causes canine papillomatosis, inclusion bodies are common in nonregressive infection, papillomavirus induces cytopathic effect and pathogenesis, viral particles located in the cell and forms crystal mode in nuclear space.

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Section: Discussionmentioning

confidence: 95%

Electron microscopy and histopathological examination of canine papilomavirus

Tekelioğlu¹

2022

Journal of Istanbul Veterinary Sciences

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“…CPV have been identified worldwide ( Sykes and Luff, 2014 ); Table 3 shows the different CPV types with their associated lesion and the country of origin. HPV studies show that different etiologies, risk factors, and the prevalence of a viral type may be associated with its geographic origin ( Sabattini et al., 2016 ).…”

Section: Genetic Diversity and Pathogenicitymentioning

confidence: 99%

“…Viral transmission occurs by cutaneous or mucosal contact facilitated by some trauma affecting the basal layer of the skin and the mucosal epithelium that results in neoplastic lesions or asymptomatic infection ( Lange et al, 2011 ; Sykes and Luff, 2014 ; Sardon et al, 2015 ). The neoplasms that have been associated with CPV are benign exophytic and endophytic papillomas, and pigmented viral plaques, with progression to malign neoplasia in the form of squamous cell carcinoma (SCC) ( Zhou et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

New insights into Canis familiaris papillomaviruses genetics and biology: Is the genetic characterization of CPV types and their variants an important clinical issue?

Reis

Batista

2022

Genet. Mol. Biol.

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Canis familiaris papillomavirus (CPV) is a member of the Papillomaviridae family and is found in dogs. After infection, the host can remain asymtomatic or develop benign ephitelial neoplasms such as papillomas and pigmented viral plaques, which can progress to cancer, in the form of squamous cell carcinoma (SCC). In humans, 227 types of human papillomavirus (HPV) have been described, with a well-established risk classification for cancer development. In addition, it is also known that variants of some high-risk HPV types may present different risks in respect of SCC development. In dogs, however, only a few types of CPV have been identified, despite the growing interest in this area, and knowledge on the genetic characterization of CPV variants is still scarce. Recent studies of CPV have shown that, as with HPV, benign neoplasia can develop into cancer, but it is believed that there are many more types and variants still to be described. Therefore, the aim of this study was to describe the genetics and biology of CPV, with the focus on what is known about lesions, geographic localization, virus types and variants.

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Clinicopathologic evaluation of oral squamous cell carcinoma in a young dog

Gürgen

Egeden²,

Şennazlı

2020

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Canine oral papilloma is a benign tumor of young dogs and caused by papillomavirus. The possible role of papillomavirus infection in the development of oral squamous cell carcinoma has recently been studied, but it has not been elucidated in veterinary medicine yet. A one-year-old, mixed, spayed, female dog was presented with severely disseminated oral lesions, lethargy, and weight loss. Physical examination of the patient revealed severely disseminated oral papillomatous lesions in the entire oral cavity and the complete blood test showed mild non-regenerative anemia and pancytopenia. In addition, the patient was found seropositive by the SNAP 4Dx Plus test for Ehrlichia canis. Histopathologic examination of oral lesions was performed using Hematoxylin and Eosin (HE) staining and immunohistochemistry for p16, antibody which increases in infections caused by papillomavirus. Histopathology revealed the histologic features of oral papilloma in association with squamous cell carcinoma. Cytoplasmic and nuclear positive reactions for p16 protein were observed within the neoplastic cells in the immunohistochemical examination. Thereafter, the dog was treated with combined therapy of vincristine, antibiotic, radiotherapy, and high doses of vitamin C. After longterm treatment, the dog completely recovered from the lesions. In this report, it was aimed to present a possible role of papilloma in the development of oral squamous cell carcinoma with the clinical, histopathological, immunohistochemical findings and treatment procedure.

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Viral Papillomatosis

Cited by 3 publications

References 42 publications

Electron microscopy and histopathological examination of canine papilomavirus

Electron microscopy and histopathological examination of canine papilomavirus

New insights into Canis familiaris papillomaviruses genetics and biology: Is the genetic characterization of CPV types and their variants an important clinical issue?

Clinicopathologic evaluation of oral squamous cell carcinoma in a young dog

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