Viral Pneumonia and Acute Respiratory Distress Syndrome

Shah, Ramila; Wunderink, Richard G.

doi:10.1016/j.ccm.2016.11.013

Cited by 64 publications

(73 citation statements)

References 171 publications

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“…11À13,16,34 However, we do not have any consensus that these CA-RVs are directly related to poor outcome and attributable mortality in this population. 11,12,34 In addition, there is no standard guideline for prevention or treatment of CA-RVs among transplant recipients and non-transplant critically ill patients in ICU. Therefore, the guideline for indication of surveillance or diagnostic tests as well as treatment of specific CA-RVs in unique high-risk subpopulation through further prospective studies needs to be standardized to implement practices effectively.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of community-acquired respiratory viruses infections except seasonal influenza in transplant recipients and non-transplant critically ill patients

Lee

Yoo

Cho

et al. 2021

Journal of Microbiology, Immunology and Infection

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Section: Discussionmentioning

confidence: 99%

Characteristics of community-acquired respiratory viruses infections except seasonal influenza in transplant recipients and non-transplant critically ill patients

Lee

Yoo

Cho

et al. 2021

Journal of Microbiology, Immunology and Infection

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“…Patients with pneumonia, sepsis, gastric aspiration, or chest trauma may readily develop ARDS. Respiratory viruses, such as influenza virus, Middle East respiratory syndrome-related coronavirus (MERS), SARS-CoV, rhinovirus, respiratory syncytial virus, parainfluenza virus, human metapneumovirus, and adenoviruses may cause viral pneumonia and severe ARDS ( Shah and Wunderink, 2017 ). SARS-CoV-2 emerged in 2019 and caused the COVID-19 outbreak.…”

Section: General Characteristics Of Covid-19 Associated Ardsmentioning

confidence: 99%

Targeting Neutrophils to Treat Acute Respiratory Distress Syndrome in Coronavirus Disease

et al. 2020

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This review describes targeting neutrophils as a potential therapeutic strategy for acute respiratory distress syndrome (ARDS) associated with coronavirus disease 2019 (COVID-19), a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Neutrophil counts are significantly elevated in patients with COVID-19 and significantly correlated with disease severity. The neutrophil-to-lymphocyte ratio can serve as a clinical marker for predicting fatal complications related to ARDS in patients with COVID-19. Neutrophil-associated inflammation plays a critical pathogenic role in ARDS. The effector functions of neutrophils, acting as respiratory burst oxidants, granule proteases, and neutrophil extracellular traps, are linked to the pathogenesis of ARDS. Hence, neutrophils can not only be used as pathogenic markers but also as candidate drug targets for COVID-19 associated ARDS.

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“…ARDS is a life-threatening complication featured by diffuse alveolar damage [22]. The incidence of ARDS varies widely, ranging from 1.5 patients per 100,000 people to nearly 79 patients per 100,000 people; European countries report lower incidence than the United States; mortality also varies due to the severity, age, and underlying medical conditions [23][24][25][26][27]. No monotherapy has been found to alter the latent pathological process of ARDS to date.…”

Section: Discussionmentioning

confidence: 99%

miR-146b-3p regulates PI3K/AKT signaling pathway in septic mice with acute respiratory distress syndrome

Liu¹,

Zhu²,

Jin³

et al. 2020

Preprint

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Background: This study aimed to explore the effect of miR-146b-3p on acute respiratory distress syndrome in septic mice by regulating PI3K/AKT signaling pathway. Methods: Seventy C57BL/6 mice were divided into normal group ( n = 10) and modeling group ( n = 60, mice for constructing septic mice models with acute respiratory distress syndrome). Model mice were subdivided into model group (without any treatment), negative control (NC) mimic group (injection with miRNA NC), miR-146b-3p mimic group (injection with miR-146b-3p mimic), si-NC group (injection with PI3Kγ siRNA NC), si-PI3Kγ group (injection with PI3Kγ interference sequence), and miR-146b-3p mimic + oe-PI3Kγ group (injection with miR-146b-3p mimic + PI3Kγ overexpression plasmid). Dual-luciferase reporter assay was conducted to determine the target relationship between miR-146b-3p and PI3Kγ. Wet weight/dry weight (W/D) ratio of the left lung was measured. Hematoxylin and eosin stain was used to detect the pathological change of mouse lung. ELISA was employed to measure serum interleukin (IL) -1β and IL-18 levels. miR-146b-3p and PI3Kγ expressions were detected by qRT-PCR. PI3Kγ, AKT, NLRP3, apoptosis-associated speck-like protein caspase recruitment domain (ASC) and Caspase-1 protein expressions were detected by Western blotting. Results: miR-146b-3p negatively regulated PI3Kγ. The lung tissues in other groups compared with normal group had down-regulated miR-146b-3p, up-regulated PI3Kγ, p-AKT, ASC, NLRP3 and Caspase-1 proteins, higher W/D ratio, and more serum IL-1β and IL-18 (all P < 0.05). All indicators in miR-146b-3p mimic group and si-PI3Kγ group were significantly improved as compared to model group (all P < 0.05). Up-regulated PI3Kγ, p-AKT, ASC, NLRP3 and Caspase-1 proteins and higher W/D ratio and IL-1β and IL-18 levels in serum existed in miR-146b-3p mimic + oe-PI3Kγ group compared with miR-146b-3p mimic group (all P < 0.05). Conclusions: Up-regulation of miR-146b-3p can restrain PI3K/AKT signaling pathway, thereby improving acute respiratory distress syndrome in septic mice.

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Viral Pneumonia and Acute Respiratory Distress Syndrome

Cited by 64 publications

References 171 publications

Characteristics of community-acquired respiratory viruses infections except seasonal influenza in transplant recipients and non-transplant critically ill patients

Characteristics of community-acquired respiratory viruses infections except seasonal influenza in transplant recipients and non-transplant critically ill patients

Targeting Neutrophils to Treat Acute Respiratory Distress Syndrome in Coronavirus Disease

miR-146b-3p regulates PI3K/AKT signaling pathway in septic mice with acute respiratory distress syndrome

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