Viral pneumonia and pulmonary alveolar proteinosis: the cause and the effect, case report

Albogami, Saeed Mishal; Touman, Abdelfattah

doi:10.21037/acr.2019.09.04

Cited by 9 publications

(14 citation statements)

References 18 publications

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“…In a study of 212 Japanese patients with aPAP, 12 (5.7%) were found to have concurrent infections (primarily aspergillosis, atypical mycobacteria, and Mycobacterium tuberculosis ), of which at least half were pulmonary infections ( 23 ). Superinfection with H1N1 influenza also has been reported, which can exacerbate aPAP ( 91 ). While the outcome of these infections is determined by a complex set of interacting pathogen and host factors, such infections are often associated with significant morbidity and mortality.…”

Section: Infections In Apapmentioning

confidence: 99%

The Role of GM-CSF Autoantibodies in Infection and Autoimmune Pulmonary Alveolar Proteinosis: A Concise Review

et al. 2021

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Autoantibodies to multiple cytokines have been identified and some, including antibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF), have been associated with increased susceptibility to infection. High levels of GM-CSF autoantibodies that neutralize signaling cause autoimmune pulmonary alveolar proteinosis (aPAP), an ultrarare autoimmune disease characterized by accumulation of excess surfactant in the alveoli, leading to pulmonary insufficiency. Defective GM-CSF signaling leads to functional deficits in multiple cell types, including macrophages and neutrophils, with impaired phagocytosis and host immune responses against pulmonary and systemic infections. In this article, we review the role of GM-CSF in aPAP pathogenesis and pulmonary homeostasis along with the increased incidence of infections (particularly opportunistic infections). Therefore, recombinant human GM-CSF products may have potential for treatment of aPAP and possibly other infectious and pulmonary diseases due to its pleotropic immunomodulatory actions.

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Section: Infections In Apapmentioning

confidence: 99%

The Role of GM-CSF Autoantibodies in Infection and Autoimmune Pulmonary Alveolar Proteinosis: A Concise Review

et al. 2021

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“…5,6 It is predominantly associated with haematological disorders but has also been found to be associated with malignancy, chronic inflammatory disease and toxic inhalation. [2][3][4][5] Of all the inhalable toxic agents, silica was found to be the most common inhaled particle in workers who developed secondary PAP. 7 This form of PAP following exposure to high concentrations of respirable crystalline silica is called acute silicoproteinosis.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Secondary PAP is less common and is associated with a range of clinical conditions that impair alveolar macrophage function and include malignancy, blood dyscrasias, immune deficiency syndromes, toxic dust inhalation as well as certain infections. [2][3][4] Congenital PAP affects children and is due to genetic mutations affecting surfactant production. 2,3 We describe a case of silicoproteinosis in a young male who tested positive for serum GM-CSF autoantibodies (GM-CSF-Ab) after working for nearly a decade as a stone benchtop fabricator.…”

Section: Introductionmentioning

confidence: 99%

“…Autoimmune PAP (aPAP), a primary form of PAP that is the most common type in adults 3 is driven by the presence of antibodies to granulocyte‐macrophage colony‐stimulating factor (GM‐CSF). Secondary PAP is less common and is associated with a range of clinical conditions that impair alveolar macrophage function and include malignancy, blood dyscrasias, immune deficiency syndromes, toxic dust inhalation as well as certain infections 2–4 . Congenital PAP affects children and is due to genetic mutations affecting surfactant production 2,3 …”

Section: Introductionmentioning

confidence: 99%

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GM‐CSF antibodies in artificial stone associated silicoproteinosis: A case report and literature review

Khan

Stirling

McLean

et al. 2022

Respirology Case Reports

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Pulmonary alveolar proteinosis (PAP) is a rare lung disease where there is accumulation of surfactant in the alveoli. It can be classified based on the underlying aetiology into three categories: primary, secondary and congenital. Autoantibodies to granulocyte‐macrophage colony‐stimulating factor (GM‐CSF‐Ab) are a key diagnostic feature of autoimmune PAP. High intensity occupational exposure and inhalation of toxic particles such as silica can cause a form of secondary PAP called acute silicoproteinosis. We describe a 26‐year‐old stone benchtop fabricator with silicoproteinosis following daily exposure to high levels of silica who had elevated serum GM‐CSF‐Ab. We discuss the role of GM‐CSF‐Ab in cases of PAP with occupational inhalational exposure and the challenges in its interpretation.

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Pulmonary alveolar proteinosis following severe COVID - 19 infection: A case report

Martin,

Kaushik,

Bajantri

2024

Respiratory Medicine Case Reports

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Viral pneumonia and pulmonary alveolar proteinosis: the cause and the effect, case report

Cited by 9 publications

References 18 publications

The Role of GM-CSF Autoantibodies in Infection and Autoimmune Pulmonary Alveolar Proteinosis: A Concise Review

The Role of GM-CSF Autoantibodies in Infection and Autoimmune Pulmonary Alveolar Proteinosis: A Concise Review

GM‐CSF antibodies in artificial stone associated silicoproteinosis: A case report and literature review

Pulmonary alveolar proteinosis following severe COVID - 19 infection: A case report

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