Viral regulation of mRNA export with potentials for targeted therapy

Guha, Shalini; Bhaumik, Sukesh R.

doi:10.1016/j.bbagrm.2020.194655

Cited by 5 publications

(7 citation statements)

References 263 publications

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“…The LRPPRC adaptor interacts with 4E-SE (eIF4E-sensitivity element)-containing mRNAs and exports these to the cytoplasm. The 4E-SE-containing mRNAs are recognized by nuclear eIF4E (eukaryotic translation initiation factor 4E) at the 7-methyl guanosine cap of the 5 ′ -end [158]. mRNA export is an important regulatory step in eukaryotic gene expression.…”

Section: Genes/proteins Identified By 1-l Transcription Of C-(aa)n-n ...mentioning

confidence: 99%

1-L Transcription of SARS-CoV-2 Spike Protein S1 Subunit

Nahalka

2024

IJMS

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The COVID-19 pandemic prompted rapid research on SARS-CoV-2 pathogenicity. Consequently, new data can be used to advance the molecular understanding of SARS-CoV-2 infection. The present bioinformatics study discusses the “spikeopathy” at the molecular level and focuses on the possible post-transcriptional regulation of the SARS-CoV-2 spike protein S1 subunit in the host cell/tissue. A theoretical protein–RNA recognition code was used to check the compatibility of the SARS-CoV-2 spike protein S1 subunit with mRNAs in the human transcriptome (1-L transcription). The principle for this method is elucidated on the defined RNA binding protein GEMIN5 (gem nuclear organelle-associated protein 5) and RNU2-1 (U2 spliceosomal RNA). Using the method described here, it was shown that 45% of the genes/proteins identified by 1-L transcription of the SARS-CoV-2 spike protein S1 subunit are directly linked to COVID-19, 39% are indirectly linked to COVID-19, and 16% cannot currently be associated with COVID-19. The identified genes/proteins are associated with stroke, diabetes, and cardiac injury.

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Section: Genes/proteins Identified By 1-l Transcription Of C-(aa)n-n ...mentioning

confidence: 99%

1-L Transcription of SARS-CoV-2 Spike Protein S1 Subunit

Nahalka

2024

IJMS

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“…In addition, viruses can promote the export of viral mRNAs that encode inhibitors of host caspases to block cell apoptosis. Thus, viruses hijack the host’s mRNA nuclear export mechanism to help them trigger a successful infection and its subsequent spread [ 147 ].…”

Section: The Nuclear Export Of Viral Mrnamentioning

confidence: 99%

Virus Infection and mRNA Nuclear Export

Guo

Zhu

et al. 2023

IJMS

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Gene expression in eukaryotes begins with transcription in the nucleus, followed by the synthesis of messenger RNA (mRNA), which is then exported to the cytoplasm for its translation into proteins. Along with transcription and translation, mRNA export through the nuclear pore complex (NPC) is an essential regulatory step in eukaryotic gene expression. Multiple factors regulate mRNA export and hence gene expression. Interestingly, proteins from certain types of viruses interact with these factors in infected cells, and such an interaction interferes with the mRNA export of the host cell in favor of viral RNA export. Thus, these viruses hijack the host mRNA nuclear export mechanism, leading to a reduction in host gene expression and the downregulation of immune/antiviral responses. On the other hand, the viral mRNAs successfully evade the host surveillance system and are efficiently exported from the nucleus to the cytoplasm for translation, which enables the continuation of the virus life cycle. Here, we present this review to summarize the mechanisms by which viruses suppress host mRNA nuclear export during infection, as well as the key strategies that viruses use to facilitate their mRNA nuclear export. These studies have revealed new potential antivirals that may be used to inhibit viral mRNA transport and enhance host mRNA nuclear export, thereby promoting host gene expression and immune responses.

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“…The protein exportin‐5 forms a transport complex with Guanosine triphosphate‐binding nuclear protein Ran‐GTP and a precursor miRNA. 43 , 44 The reduction of Guanosine triphosphate impairs the migration of precursor miRNA‐bound Ran. Therefore, it is considered that exportin‐5 depends on the nuclear Ran‐GTP to perform its functions.…”

Section: Biogeny Of Mirnamentioning

confidence: 99%

“…The consequential precursor miRNA is migrated to the cytoplasm where maturation can be completed. The protein exportin‐5 forms a transport complex with Guanosine triphosphate‐binding nuclear protein Ran‐GTP and a precursor miRNA 43,44 . The reduction of Guanosine triphosphate impairs the migration of precursor miRNA‐bound Ran.…”

Section: Biogeny Of Mirnamentioning

confidence: 99%

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miRNA‐encapsulated abiotic materials and biovectors for cutaneous and oral wound healing: Biogenesis, mechanisms, and delivery nanocarriers

Dey

Yousefiasl

Kumar

et al. 2022

Bioengineering & Transla Med

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MicroRNAs (miRNAs) as therapeutic agents have attracted increasing interest in the past decade owing to their significant effectiveness in treating a wide array of ailments. These polymerases II‐derived noncoding RNAs act through post‐transcriptional controlling of different proteins and their allied pathways. Like other areas of medicine, researchers have utilized miRNAs for managing acute and chronic wounds. The increase in the number of patients suffering from either under‐healing or over‐healing wound demonstrates the limited efficacy of the current wound healing strategies and dictates the demands for simpler approaches with greater efficacy. Various miRNA can be designed to induce pathway beneficial for wound healing. However, the proper design of miRNA and its delivery system for wound healing applications are still challenging due to their limited stability and intracellular delivery. Therefore, new miRNAs are required to be identified and their delivery strategy needs to be optimized. In this review, we discuss the diverse roles of miRNAs in various stages of wound healing and provide an insight on the most recent findings in the nanotechnology and biomaterials field, which might offer opportunities for the development of new strategies for this chronic condition. We also highlight the advances in biomaterials and delivery systems, emphasizing their challenges and resolutions for miRNA‐based wound healing. We further review various biovectors (e.g., adenovirus and lentivirus) and abiotic materials such as organic and inorganic nanomaterials, along with dendrimers and scaffolds, as the delivery systems for miRNA‐based wound healing. Finally, challenges and opportunities for translation of miRNA‐based strategies into clinical applications are discussed.

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Viral regulation of mRNA export with potentials for targeted therapy

Cited by 5 publications

References 263 publications

1-L Transcription of SARS-CoV-2 Spike Protein S1 Subunit

1-L Transcription of SARS-CoV-2 Spike Protein S1 Subunit

Virus Infection and mRNA Nuclear Export

miRNA‐encapsulated abiotic materials and biovectors for cutaneous and oral wound healing: Biogenesis, mechanisms, and delivery nanocarriers

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