Viral RNA Load in Mildly Symptomatic and Asymptomatic Children with COVID-19, Seoul, South Korea

Han, Mi Seon; Seong, Moon Woo; Kim, Namhee; Shin, Sue; Cho, Sung Im; Park, Hyunwoong; Kim, Taek Soo; Park, Sung Sup; Choi, Eun Hwa

doi:10.3201/eid2610.202449

Cited by 187 publications

(227 citation statements)

References 8 publications

Supporting

Mentioning

199

Contrasting

Unclassified

Order By: Relevance

“…In 9 patients with confirmed SARS-CoV-2 infections one of the patients was positive for viral RNA in urine [150]. This observation is supported by observations among 12 SARS-CoV-2 positive children with 2 of them positive for viral RNA in urine (17%) [119]. Importantly, infectious virus could be detected from urine in one COVD-19 patient [151].…”

Section: Urinary Tractsupporting

confidence: 58%

“…In contrast, one study described the successful isolation of virus by cell culture from 2 out of 3 patients [118]. Of note, another study showed higher viral RNA loads in fecal samples of mildly symptomatic or asymptomatic children compared to nasopharyngeal swabs [119]. These results indicate the possibility of fecal-oral transmission or fecal-respiratory transmission through aerosolized feces.…”

Section: Gastrointestinal Tract / Stoolmentioning

confidence: 98%

See 1 more Smart Citation

Potential sources, modes of transmission and effectiveness of prevention measures against SARS-CoV-2

Kampf

Brüggemann

Kaba

et al. 2020

Journal of Hospital Infection

131

121

View full text Add to dashboard Cite

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Section: Urinary Tractsupporting

confidence: 58%

Section: Gastrointestinal Tract / Stoolmentioning

confidence: 98%

Potential sources, modes of transmission and effectiveness of prevention measures against SARS-CoV-2

Kampf

Brüggemann

Kaba

et al. 2020

Journal of Hospital Infection

131

121

View full text Add to dashboard Cite

show abstract

“…SARS-CoV-2 viral load is highest at the onset of illness and wanes over time regardless of age or illness severity, as the authors themselves argue (Figure 2, panel C) ( 3 , 4 ). While the authors state that viral loads in children were high, they were not higher than levels reported by others in either adults or children at similar time points after onset of symptoms ( 5 , 6 , 7 ). Inferring anything about the infectivity of the COVID-19 positive children is speculative.…”

contrasting

confidence: 52%

You say potato, I say tomato: Reassessing severe acute respiratory syndrome coronavirus 2 viral loads in children

Lee

Raszka

2021

The Journal of Pediatrics

View full text Add to dashboard Cite

“…Questions relating to the role of viral carriage in the pediatric population can be addressed using these samples. Case reports and recent research studies suggests that asymptomatic children carry high viral loads despite lack of symptoms [4][5][6]. In adults, severe infection is not necessarily associated with a signi cant increase in viral loads by nasopharyngeal swab [7], and asymptomatic individuals appear to have equal viral loads as symptomatic individuals [8].…”

Section: Inform Pediatric Contribution To Viral Transmissionmentioning

confidence: 99%

Establishment of a Pediatric COVID-19 Biorepository: Unique Considerations and Opportunities for Studying the Impact of the COVID-19 Pandemic on Children

Lima

Gootkind

Flor

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: COVID-19, the disease caused by the highly infectious and transmissible coronavirus SARS-CoV-2, has quickly become a morbid global pandemic. Although the impact of SARS-CoV-2 infection in children is less clinically apparent, collecting high-quality biospecimens from infants, children, and adolescents in a standardized manner during the COVID-19 pandemic is essential to establish a biologic understanding of the disease in the pediatric population. This biorepository enables pediatric centers world-wide to collect samples uniformly to drive forward our understanding of COVID-19 by addressing specific pediatric and neonatal COVID-19-related questions. Methods: A COVID-19 biospecimen collection study was implemented with strategic enrollment guidelines to include patients seen in urgent care clinics and hospital settings, neonates born to SARS-CoV-2 infected mothers, and asymptomatic children. The methodology described here, details the importance of establishing collaborations between the clinical and research teams to harmonize protocols for patient recruitment and sample collection, processing and storage. It also details modifications required for biobanking during a surge of the COVID-19 pandemic.Results: Considerations and challenges facing enrollment of neonatal and pediatric cohorts are described. A roadmap is laid out for successful collection, processing, storage and database management of multiple pediatric samples such as blood, nasopharyngeal and oropharyngeal swabs, sputum, saliva, tracheal aspirates, stool, and urine. Using this methodology, we enrolled 327 participants, who provided a total of 972 biospecimens.Conclusions: Pediatric biospecimens will be key in answering questions relating to viral transmission by children, differences between pediatric and adult viral susceptibility and immune responses, the impact of maternal SARS-CoV-2 infection on fetal development, and factors driving the Multisystem Inflammatory Syndrome in Children. The specimens in this biorepository will allow necessary comparative studies between children and adults, help determine the accuracy of current pediatric viral testing techniques, in addition to, understanding neonatal exposure to SARS-CoV-2 infection and disease abnormalities. The successful establishment of a pediatric biorepository is critical to provide insight into disease pathogenesis, and subsequently, develop future treatment and vaccination strategies.

show abstract

Viral RNA Load in Mildly Symptomatic and Asymptomatic Children with COVID-19, Seoul, South Korea

Cited by 187 publications

References 8 publications

Potential sources, modes of transmission and effectiveness of prevention measures against SARS-CoV-2

Potential sources, modes of transmission and effectiveness of prevention measures against SARS-CoV-2

You say potato, I say tomato: Reassessing severe acute respiratory syndrome coronavirus 2 viral loads in children

Establishment of a Pediatric COVID-19 Biorepository: Unique Considerations and Opportunities for Studying the Impact of the COVID-19 Pandemic on Children

Contact Info

Product

Resources

About