Virchow's node, jaundice, and weight loss—lymphoma mimicking gastrointestinal malignancy

Anastassiades, Constantinos P.; Poterucha, Thomas H.

doi:10.1038/ncpgasthep0635

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…First described in the literature by German pathologist Rudolf Virchow, MD, in 1848 as an enlarged gland that was associated with gastric cancers, it has come to be known as a signal node, signaling the presence of an underlying cancer from a primary lesion in the upper abdomen (Bickley, 2009). Although strongly associated with the presence of gastric carcinomas, case reports in the literature link Virchow's node with primary breast, lung, intestine, pancreas, testicular, and bladder carcinomas, as well as lymphoma (Anastassiades & Poterucha, 2006;Cervin, Silverman, Loggie, & Geisinger, 1995;Hemalatha, Batra, Ramah, & Shashikumar, 2013;Komala, 2014). In contrast, the enlargement of the right supraclavicular lymph node is more often associated with Hodgkin and non-Hodgkin lymphoma, as well as lung and esophageal cancers (Cervin et al, 1995).…”

Section: Signal Nodesmentioning

confidence: 99%

Virchow’s Node and Carcinoma of Unknown Primary

Streu¹

2015

ONF

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Section: Signal Nodesmentioning

confidence: 99%

Virchow’s Node and Carcinoma of Unknown Primary

Streu¹

2015

ONF

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“…Thus, the Virchow node typically signals metastasis from the gut, 1 , 2 esophagus, 4 liver, 5 biliary tree, 6 pancreas, 7 urogenital organs, 3 , 8 and lungs. 9 The Virchow node has also signaled lymphoma, 10 squamous cell carcinoma, 8 and active tuberculosis. 11 …”

Section: Introductionmentioning

confidence: 99%

Bilateral Virchow nodes: an unusual finding of pulmonary small-cell neuroendocrine carcinoma metastasis

Zdilla,

Gross,

Hajarat

et al. 2023

Autops Case Rep

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An enlarged left-sided supraclavicular node is a signal node for cancer metastasis. In such a case, the enlarged lymph node is often referred to as a Virchow node. The left-sided nature of the node is due to the drainage of the thoracic duct. So, the enlargement of a Virchow node is typically associated with malignancies, including gastrointestinal, pulmonary, and genitourinary carcinomas, in addition to lymphomas. This report documents a particularly unusual finding: bilateral Virchow nodes, representing metastasis of small-cell neuroendocrine carcinoma.

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“…In addition, the VN has been identified as a seeding location for cancers arising from myriad locations apart from the stomach, including the intestines,7 urogenital system,10 - 18 esophagus,19 common bile duct,20 liver,21 - 23 as well as the pancreas,24 , 25 and lungs 26. The VN has also been reported with squamous cell carcinoma and lymphoma 16 , 27 , 28. Furthermore active tuberculosis has manifested as a VN 29.…”

Section: Introductionmentioning

confidence: 99%

Troisier sign and Virchow node: the anatomy and pathology of pulmonary adenocarcinoma metastasis to a supraclavicular lymph node

Zdilla¹,

Aldawood²,

Plata³

et al. 2019

Autops. Case Rep.

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Metastatic spread of cancer via the thoracic duct may lead to an enlargement of the left supraclavicular node, known as the Virchow node (VN), leading to an appreciable mass that can be recognized clinically — a Troisier sign. The VN is of profound clinical importance; however, there have been few studies of its regional anatomical relationships. Our report presents a case of a Troisier sign/VN discovered during cadaveric dissection in an individual whose cause of death was, reportedly, chronic obstructive pulmonary disease. The VN was found to arise from an antecedent pulmonary adenocarcinoma. Our report includes a regional study of the anatomy as well as relevant gross pathology and histopathology. Our anatomical findings suggest that the VN may contribute to vascular thoracic outlet syndrome as well as the brachial plexopathy of neurogenic thoracic outlet syndrome. Further, the VN has the potential to cause compression of the phrenic nerve, contributing to unilateral phrenic neuropathy and subsequent dyspnea. Recognition of the Troisier sign/VN is of great clinical importance. Similarly, an appreciation of the anatomy surrounding the VN, and the potential for the enlarged node to encroach on neurovascular structures, is also important in the study of a patient. The presence of a Troisier sign/VN should be assessed when thoracic outlet syndrome and phrenic neuropathy are suspected. Conversely, when a VN is identified, the possibility of concomitant or subsequent thoracic outlet syndrome and phrenic neuropathy should be considered.

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Virchow's node, jaundice, and weight loss—lymphoma mimicking gastrointestinal malignancy

Abstract: Large-volume thoracentesis. Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone chemotherapy followed by dexamethasone, cytarabine, and cisplatin chemotherapy, and autologous stem-cell transplantation.

Cited by 4 publications

References 10 publications

Virchow’s Node and Carcinoma of Unknown Primary

Virchow’s Node and Carcinoma of Unknown Primary

Bilateral Virchow nodes: an unusual finding of pulmonary small-cell neuroendocrine carcinoma metastasis

Troisier sign and Virchow node: the anatomy and pathology of pulmonary adenocarcinoma metastasis to a supraclavicular lymph node

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