Virgin olive oil reduces blood pressure in hypertensive elderly subjects

Perona, Javier S.

doi:10.1016/j.clnu.2004.02.004

Cited by 101 publications

(69 citation statements)

References 72 publications

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“…24 Olive oil contains a high amount of oleic acid and is reported to decrease blood pressure in humans. [25][26][27] Here we show that the attenuation of hypertension after TTA treatment is accompanied by increased levels of oleic acid and its metabolites palmitoleic acid and icosatrienoic acid, probably because of increased ⌬9 desaturase activity. 28 An elevated level of palmitic acid 9 and a reduced level of stearic acid 8 in serum cholesteryl esters are associated with higher risk of hypertension; however, in the present study, no change was seen in the serum levels of these fatty acids.…”

Section: Gudbrandsen Et Al Prevention Of Renal Hypertension 463mentioning

confidence: 59%

Prevention of Hypertension and Organ Damage in 2-Kidney, 1-Clip Rats by Tetradecylthioacetic Acid

et al. 2006

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Abstract-Dietary lipids are reported to affect the blood pressure in both humans and experimental animal models with hypertension. In the present study, 2-kidney, 1-clip (2K1C) hypertensive rats were treated with the modified fatty acid tetradecylthioacetic acid (TTA) from the time of clipping or after hypertension was established. TTA treatment attenuated the development of hypertension and reduced established 2K1C hypertension. The mRNA level of renin in the clipped kidney and the plasma renin activity were markedly reduced, and the plasma angiotensin II level tended to decrease after TTA treatment. In addition, TTA reduced the mRNA level of angiotensinogen in white adipose tissue.Prevention of organ damage was demonstrated by normal urinary excretion of protein, maintained serum albumin, lower heart weight, and clearly reduced vascular, glomerular, and tubulointerstitial damage in the nonclipped kidney. Renal function was not affected as estimated by unchanged plasma creatinine. Furthermore, the serum levels of triacylglycerol and cholesterol were reduced by TTA. The serum fatty acid composition was changed, resulting in a favorable increase of oleic acid. However, the levels of all of the omega-3 fatty acids and of linoleic acid were reduced, and no change was seen in the level of arachidonic acid, but the urinary excretion of 8-iso-prostaglandin F2␣ was declined. In conclusion, TTA attenuated the development of hypertension, reduced established hypertension, and prevented the development of organ damage in 2K1C rats, possibly by reducing the amounts of the vasoconstrictors angiotensin II and 8-iso-prostaglandin F2␣ and by inducing a favorable increase of oleic acid in serum. Key Words: renin-angiotensin system Ⅲ renal disease Ⅲ fatty acids E levated blood pressure is closely related to increase in cardiovascular death from events like stroke, myocardial infarction, and chronic renal failure 1 and is defined as one of the risk factors for the metabolic syndrome. 2,3 Other risk factors include insulin resistance, hyperglycemia, and elevated serum triacylglycerol, which are conditions that are improved in rats after treatment with the modified fatty acid tetradecylthioacetic acid (TTA). 4 The pleiotropic effects of TTA seem to be mediated through both peroxisome proliferator-activated receptor (PPAR)-dependent and PPAR-independent mechanism 4 and include changes in the fatty acid composition of both liver and serum in rats. [5][6][7] Based on these potential possibilities to change composition of the metabolic system, and because the fatty acid composition of cholesteryl ester and phospholipids in serum has been related to the blood pressure level in humans, 8 -10 we examined the effect of TTA on hypertension in the present study.An inducible model of high blood pressure is the 2-kidney, 1-clip (2K1C) hypertension model, where the increased blood pressure is induced after clipping of one renal artery. This is an angiotensin II-dependent model of hypertension with increased level of plasma renin and angioten...

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Section: Gudbrandsen Et Al Prevention Of Renal Hypertension 463mentioning

confidence: 59%

Prevention of Hypertension and Organ Damage in 2-Kidney, 1-Clip Rats by Tetradecylthioacetic Acid

et al. 2006

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“…Recruitment of inflammatory cells into the kidney starts with their interaction with selectins found on endothelial cells, which were reduced with a Mediterranean diet in a controlled study in humans (31). Inflammatory biomarkers, lipid profile, and BP have all been favorably affected by a Mediterranean diet (as a whole or its components) in several randomized trials, which may also translate into beneficial kidney effects (32,(34)(35)(36)(37)(38).…”

Section: Discussionmentioning

confidence: 99%

The Association between a Mediterranean-Style Diet and Kidney Function in the Northern Manhattan Study Cohort

Khatri¹,

Moon

Scarmeas

et al. 2014

Clinical Journal of the American Society of Nephrology

116

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Background and objectives Various dietary strategies have been investigated to slow kidney function decline. However, it is unknown whether a Mediterranean diet, which has been associated with improved cardiovascular risk, is associated with change in kidney function.Design, setting, participants, & measurements This study used the Northern Manhattan Study, a prospective, multiethnic, observational cohort of participants who were stroke free at baseline. Data were collected between 1993 and 2008. Serum creatinine measurements were taken a mean 6.9 years apart. A baseline dietary questionnaire was extrapolated into a previously used 9-point scoring system (MeDi). The primary outcome was incident eGFR,60 ml/min per 1.73 m 2 using the Modification of Diet in Renal Disease formula. A secondary outcome was the upper quartile of annualized eGFR decline ($2.5 ml/min per 1.73 m 2 per year). Conditional logistic regression models adjusted for demographics and baseline vascular risk factors.Results Mean baseline age was 64 years, with 59% women and 65% Hispanics (N=900); mean baseline eGFR was 83.1 ml/min per 1.73 m 2 . Incident eGFR,60 ml/min per 1.73 m 2 developed in 14% . In adjusted models, every 1-point increase in the MeDi score, indicating increasing adherence to a Mediterranean diet, was associated with decreased odds of incident eGFR,60 ml/min per 1.73 m 2 (odds ratio, 0.83; 95% confidence interval, 0.71 to 0.96) and decreased odds of being in the upper quartile of eGFR decline (odds ratio, 0.88; 95% confidence interval, 0.79 to 0.98).Conclusions A Mediterranean diet was associated with a reduced incidence of eGFR,60 ml/min per 1.73 m 2 and upper quartile of eGFR decline in a multiethnic cohort.

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“…showed that a diet enriched with 60 g of virgin olive oil, compared with 60 g of sunflower oil, daily for 4 weeks, reduced systolic but not diastolic BP in a group of 31 hypertensives, with no effect on 31 normotensive individuals 35 . In the same way, fish oil but not olive oil was effective in the reduction of diastolic BP in a crossover study on 10 hypertensive subjects (9 g fish oil or 9 g olive oil daily for 6 weeks) 27 .…”

Section: Feeding Trialsmentioning

confidence: 98%

Monounsaturated fatty acids, olive oil and blood pressure: epidemiological, clinical and experimental evidence

Alonso

Ruı́z-Gutı́errez

Martínez‐González

2006

Public Health Nutr.

108

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Diet has an important role in the prevention and treatment of hypertension. In early epidemiological studies, conducted mainly in the USA, monounsaturated fatty acids showed a deleterious association with blood pressure or no relationship at all. However, more recent studies, conducted in Mediterranean countries, have shed new light on this issue. In the present review we summarise the main results of epidemiological studies and feeding trials, and explain the possible mechanisms through which monounsaturated fatty acids, and specifically olive oil as the major dietary source of this type of fat in Mediterranean countries, could exert a favourable effect on blood pressure.

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Virgin olive oil reduces blood pressure in hypertensive elderly subjects

Abstract: Dietary VOO proved to be helpful in reducing the systolic pressure of treated HT elderly subjects. However, a greater resistance to the lowering effect of VOO of total and LDL-cholesterol and a greater susceptibility to TG oxidation was detected in these patients.

Cited by 101 publications

References 72 publications

Prevention of Hypertension and Organ Damage in 2-Kidney, 1-Clip Rats by Tetradecylthioacetic Acid

Prevention of Hypertension and Organ Damage in 2-Kidney, 1-Clip Rats by Tetradecylthioacetic Acid

The Association between a Mediterranean-Style Diet and Kidney Function in the Northern Manhattan Study Cohort

Monounsaturated fatty acids, olive oil and blood pressure: epidemiological, clinical and experimental evidence

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