Virginal and gravid mammary gigantism—recurrence after reduction mammaplasty

Extreme Idiopathic gigantomastia

“…4 Pregnancy could be an aggravating factor due to the relative elevation of oestrogen. 19 Some authors recommend a delay of pregnancy of two years after surgery.…”

Rapid, massive and unphysiological breast enlargement

“…8) The hormonal control of mammary growth is complex [50,85] and exogenous supply of hormones carl change the hormonal system [9,14,29,50,55,58,93,106]. However, hormone levels are found to be normal [18,19,34,39,43,48,79,80,91,109], as are skull x-rays [80,107], but there has been one case with an increased level of prolactin [66] and one with mild hypothyroidism [67]. The condition is probably caused by abnorhaal end organ reaction of the breast to hormonal factors [5,18,34,43,48,50,53,54,61,63,67,76,80,87,91,109,112,114].…”

“…However, hormone levels are found to be normal [18,19,34,39,43,48,79,80,91,109], as are skull x-rays [80,107], but there has been one case with an increased level of prolactin [66] and one with mild hypothyroidism [67]. The condition is probably caused by abnorhaal end organ reaction of the breast to hormonal factors [5,18,34,43,48,50,53,54,61,63,67,76,80,87,91,109,112,114]. Because of this, endocrine therapy is by and large unsuccessful [5,6,13,41,42,45,50,56,61,86] or even contraindicated [5,52,76], although there have been reports of success using various drug regimens [13,80,87,…”

“…The condition is probably caused by abnorhaal end organ reaction of the breast to hormonal factors [5,18,34,43,48,50,53,54,61,63,67,76,80,87,91,109,112,114]. Because of this, endocrine therapy is by and large unsuccessful [5,6,13,41,42,45,50,56,61,86] or even contraindicated [5,52,76], although there have been reports of success using various drug regimens [13,80,87,109,1121.…”

“…The usual treatment is reduction mammoplasty with or without free nipple transplantation [18,43,53,66,76,80,87,91,107,109,112]. Reoperation may be necessary for continued growth [5,18,66,76,91,107,109,112].…”