Virginal gigantomastia: Validity of combined surgical and hormonal treatments

Virginal breast hypertrophy in a patient with Beckwith–Wiedemann syndrome

“…In the study by Morimoto et al , an increased estrogen receptor staining by immunohistochemistry in the fibroadenoma‐like nodules resected from both breasts of the patients with VBH has been reported. However, in another study by Glisoci et al , no increase in estrogen or progesterone receptors has been demonstrated. Therefore, it seems that the estrogen theory for dysregulated breast growth is more complex, and includes not only increased estrogen receptor density in the breast tissue, but also an excess local estrogen production, abnormal estrogen receptor sensitivity, and, possibly, the presence of an estrogen‐like substance in the body, which stimulates receptors when normal level of estrogens is present .…”

Bilaterally symmetric juvenile fibroadenomas and tubular breast deformity in a prepubescent girl

“…Similarly, recurrence rates are high after reduction mammoplasty in patients with VBH if during the period of end-organ hypersensitivity [4,5]. In an effort to curb the growth of the breast tissue in VBH, some antiestrogen hormones have been used in combination with reduction mammoplasties [14] or as a sole treatment option [15] with varying results. The treatment of CP varies from wide local excision to total mastectomy based on the extent of the disease [16].…”

Récidive d'une gigantomastie après mammoplastie. À propos d'un cas et revue de la littérature

“…La majorité des auteurs proposent l'hormonothérapie comme traitement de première intention par médroxyproges-térone, dydrogestérone, tamoxifène, danazol, les androgènes ou la gosereline [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. À fortes doses, ce médicament peut entraîner l'arrêt voire même la régression de la gigantomastie surtout dans sa forme gravidique [15].…”

“…La grossesse en serait une des causes, en raison de l'hyperestrogénie associée [8][9][10][11][12][13][14][15][16][17]. Certains auteurs préfèrent la mastectomie simple à cause du vol sanguin assez important occasionné par l'engorgement mammaire, d'autant plus que l'hémostase est mieux contrôlée en cas de mastectomie.…”