2012
DOI: 10.1128/jvi.01154-12
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Virion-Associated Complement Regulator CD55 Is More Potent than CD46 in Mediating Resistance of Mumps Virus and Vesicular Stomatitis Virus to Neutralization

Abstract: Enveloped viruses can incorporate host cell membrane proteins during the budding process. Here we demonstrate that mumps virus (MuV) and vesicular stomatitis virus (VSV) assemble to include CD46 and CD55, two host cell regulators which inhibit propagation of complement pathways through distinct mechanisms. Using viruses which incorporated CD46 alone, CD55 alone, or both CD46 and CD55, we have tested the relative contribution of these regulators in resistance to complement-mediated neutralization. Virion-associ… Show more

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Cited by 25 publications
(55 citation statements)
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“…CV1-derived virus was also neutralized by NAGS, but effective neutralization was not seen at higher dilutions. These data are consistent with the proposal that host cell-derived inhibitors of C’ are incorporated into paramyxovirus particles (Johnson et al, 2012), and that they block C’ pathways in a species specific manner. Most importantly for this study, the finding that AGM-derived PIV5 is more resistant to C’ neutralization by NAGS further highlights the importance of C’ in determining the potency of antibodies that are elicited during an infection by parainfluenza viruses.…”
Section: Resultssupporting
confidence: 91%
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“…CV1-derived virus was also neutralized by NAGS, but effective neutralization was not seen at higher dilutions. These data are consistent with the proposal that host cell-derived inhibitors of C’ are incorporated into paramyxovirus particles (Johnson et al, 2012), and that they block C’ pathways in a species specific manner. Most importantly for this study, the finding that AGM-derived PIV5 is more resistant to C’ neutralization by NAGS further highlights the importance of C’ in determining the potency of antibodies that are elicited during an infection by parainfluenza viruses.…”
Section: Resultssupporting
confidence: 91%
“…A similar result was reported for influenza virus, where serum samples from influenza-naïve mice neutralized influenza virus particles by forming viral aggregates, though neither natural IgM nor C’ alone was sufficient for neutralization (Jayasekera et al, 2007). Thus, in contrast to other negative strand RNA viruses such as VSV and HPIV3 which show C’-dependent virion lysis (Johnson et al, 2012; Vasantha et al, 1988), there was no evidence that exposure to AGM serum resulted in release of PIV5 nucleocapsids from within the lipid envelope. Importantly, sera from inoculated animals also neutralized PIV5 through this common mechanism, with the only discernable difference between pre- and post-immune sera being the kinetics of virus aggregation.…”
Section: Discussionmentioning
confidence: 75%
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“…Besides inducing typically low levels of neutralizing antibody, multiple reports indicate that the frequency of mumps-specific memory B-cells is also very low (35,58,59). It may be reasonable to try to improve the neutralizing antibody response by (re)directing it toward HN rather than NP, but other effects of antibodies, such as complement fixation, should not be overlooked (60,61). Also, antibodies that are nonneutralizing in vitro may have other underestimated roles in vivo (62).…”
Section: Discussionmentioning
confidence: 99%