Virola oleifera-capped gold nanoparticles showing radical-scavenging activity and low cytotoxicity

Corrêa, Andressa dos Santos; Contreras, Luis; Keijok, Wanderson Juvencio; Barcelos, Divan Henrique Fernandes; Pereira, Ana Cláudia Hertel; Kitagawa, Rodrigo Rezende; Scherer, Rodrigo; Gomes, Daniel; Silva, André Romero da; Endringer, Denise Coutinho; Oliveira, Jairo Pinto de; Guimarães, Marco César Cunegundes

doi:10.1016/j.msec.2018.06.027

Cited by 12 publications

(9 citation statements)

References 36 publications

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“…Anddresa et al [ 53 ] used Virola oleifera exudate as a potential capping and stabilizing agent for the formulation of gold (Au) nanoparticles. With the capping agent, the zeta potential of the formulated Au nanoparticles was observed to shift from a negatively charged to a positively charged surface.…”

Section: Introductionmentioning

confidence: 99%

Role of capping agents in the application of nanoparticles in biomedicine and environmental remediation: recent trends and future prospects

et al. 2020

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Capping agents are of utmost importance as stabilizers that inhibit the over-growth of nanoparticles and prevent their aggregation/coagulation in colloidal synthesis. The capping ligands stabilize the interface where nanoparticles interact with their medium of preparation. Specific structural features of nanoparticles are attributed to capping on their surface. These stabilizing agents play a key role in altering the biological activities and environmental perspective. Stearic effects of capping agents adsorbed on the surface of nanoparticles are responsible for such changing physico-chemical and biological characteristics. Firstly, this novel review article introduces few frequently used capping agents in the fabrication of nanoparticles. Next, recent advancements in biomedicine and environmental remediation approaches of capped nanoparticles have been elaborated. Lastly, future directions of the huge impact of capping agents on the biological environment have been summarized.

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Section: Introductionmentioning

confidence: 99%

Role of capping agents in the application of nanoparticles in biomedicine and environmental remediation: recent trends and future prospects

et al. 2020

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“…The IC 50 of AuNPs biosynthesized by Olax nana on HepG2 cells was 2.97 mg/L [22]. Previous studies have revealed that AuNPs could be uptaken by cells through the clathrin-mediated endocytosis pathway [12,38]. Thus, the cytotoxicity of BLAuNPs and ECAuNPs to CCD966SK and HEMn cells can be prevented in a similar manner.…”

Section: Cell Viability Assessmentmentioning

confidence: 84%

“…After storage for 3 months, no change was detected in the band wavelength and intensity, indicating that both AuNPs were highly stable. The particle sizes of BLAuNPs and ECAuNPs were 5.6 ± 0.3 nm (at pH 8.0) and 4.2 ± 0.5 nm (at pH 5.0), respectively-smaller than the particle size of AuNPs synthesized by most plants, such as Crescentia cujete L. (32.98 nm), Virola oleifera (15 nm), and Convolvulus fruticosus (35 nm) [12,19,20], and some bacteria, such as Bacillus sp. (12-32 nm) and Streptomyces sp.…”

Section: Effect Of Ph On the Particle Size Of Aunpsmentioning

confidence: 85%

“…Mushroom tyrosinase was purchased from Sigma Chemical Co. (St. Louis, MO, USA). The 5-nm AuNPs (Chemicals-5 nm) were chemically synthesized using the classical method with sodium citrate [12] purchased from a local company (Li-hsin Chemical Company, Taiwan).…”

Section: Methodsmentioning

confidence: 99%

“…(10-30 nm) [3,21]. The relatively large size of AuNPs synthesized by plants may be due to the capped protein from plant extract adsorbed onto the AuNPs surface [12]. Additionally, the zeta potential of the BLAuNPs changed from +16.3 ± 1.6 mV at pH 4.0 to −28.2 ± 0.9 mV at pH 5.0 and that of the ECAuNPs changed from +23.6 ± 1.2 mV at pH 5.5 to −25.1 ± 1.6 mV at pH 8.0, leading to the stability of the nanoparticle.…”

Section: Effect Of Ph On the Particle Size Of Aunpsmentioning

confidence: 99%

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Multifunctional Activities of Gold Nanoparticles Biosynthesized Using Bacteria Isolated from Mining Areas

et al. 2021

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Research on gold nanoparticles (AuNPs) has often focused on their physical, chemical, and crystalline characteristics. Commercial AuNPs have been applied in the diverse fields of biomedicine, catalysis, photovoltaics, and sensing. In this study, we explored the various activities of AuNPs to widen their applicability. This paper presents a simple and rapid synthesis process of AuNPs with bacteria isolated from a gold mining area. We also investigated the optimization of reaction parameters for AuNP synthesis. The study results revealed that among the isolated strains, Bifidobacterium lactis and Escherichia coli demonstrated the highest capabilities of AuNP synthesis. The optimal pH values for AuNP synthesis by B. lactis (BLAuNPs) and E. coli (ECAuNPs) were 5.0 for 72 h of incubation and 8.0 for 24 h of incubation. The average particle sizes of ECAuNPs and BLAuNPs were 4.2 and 5.6 nm, respectively. Furthermore, these biogenic AuNPs were found to be stable with no aggregation after 3 months of storage. BLAuNPs and ECAuNPs exhibited high levels of antimicrobial, antioxidant, photocatalytic, and antityrosinase activity. Moreover, they were noncytotoxic to skin cells even at 100% melanin inhibitory concentrations. Considering the demonstrated multifunctional activities of AuNPs, BLAuNPs and ECAuNPs have promising potential for commercialization.

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The Use of Capping Agents in the Stabilization and Functionalization of Metallic Nanoparticles for Biomedical Applications

Pedroso‐Santana

Fleitas‐Salazar

2022

Part & Part Syst Charact

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The study of nanoparticles (NPs) and their application in different areas of research, including biomedicine, is attracting the attention of researchers worldwide. Numerous investigations published during the last 20 years cover the fabrication of new materials in the nanoscale, and several uses have been proposed. Metallic nanoparticles (MNPs) have generated a high level of interest, based on improved optical, electrical and magnetic properties, ease of manufacturing, small sizes, and easy functionalization. However, when it comes to Biomedicine, particle aggregation, possible toxicity, and the need for effective cell internalization, still demand active investigation. The main strategy to overcome these drawbacks is possibly the use of capping agents to increase the stability of the particles in dispersion, their biocompatibility and functionalization. In this review, important concepts and characteristics of MNPs, are collected and described. The importance of surface coating for biomedical applications of metallic nanoparticles as well as the most used capping agents and metallic nanomaterials, are also discussed. Finally, the text includes examples and essential characteristics for the biomedical use of MNPs, including the consideration of important challenges. Aspects such as relevant biological activity, increased biocompatibility and functionalization potential are among the most desirable attributes of a capping agent.

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Virola oleifera-capped gold nanoparticles showing radical-scavenging activity and low cytotoxicity

Cited by 12 publications

References 36 publications

Role of capping agents in the application of nanoparticles in biomedicine and environmental remediation: recent trends and future prospects

Role of capping agents in the application of nanoparticles in biomedicine and environmental remediation: recent trends and future prospects

Multifunctional Activities of Gold Nanoparticles Biosynthesized Using Bacteria Isolated from Mining Areas

The Use of Capping Agents in the Stabilization and Functionalization of Metallic Nanoparticles for Biomedical Applications

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