Virological and Epidemiological Evidence of Avian Influenza Virus Infections Among Feral Dogs in Live Poultry Markets, China: A Threat to Human Health?

Su, Shuo; Zhou, Pei; Fu, Xinliang; Wang, Lifang; Hong, Malin; Lü, Gang; Sun, Li; Qi, Wenbao; Ning, Zhangyong; Jia, Kun; Yuan, Zihao; Wang, Heng; Ke, Changwen; Wu, Jie; Zhang, Guihong; Gray, Gregory C.; Li, Shoujun

doi:10.1093/cid/ciu154

Cited by 44 publications

(35 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dogs are also infected by avian influenza viruses in poultry markets (Su et al, 2014). Our findings show that dogs may be hosts for human influenza viruses (pdm H1N1 and human H3N2) and may be co-infected with canine H3N2 virus.…”

mentioning

confidence: 73%

Canine susceptibility to human influenza viruses (A/pdm 09H1N1, A/H3N2 and B)

Song

Kim

et al. 2015

Journal of General Virology

View full text Add to dashboard Cite

We investigated the infectivity and transmissibility of the human seasonal H3N2, pandemic (pdm) H1N1 (2009) and B influenza viruses in dogs. Dogs inoculated with human seasonal H3N2 and pdm H1N1 influenza viruses exhibited nasal shedding and were seroconverted against the viruses; this did not occur in the influenza B virus-inoculated dogs. Transmission of human H3N2 virus between dogs was demonstrated by observing nasal shedding and seroconversion in naïve dogs after contact with inoculated dogs. The seroprevalence study offered evidence of human H3N2 infection occurring in dogs since 2008. Furthermore, serological evidence of pdm H1N1 influenza virus infection alone and in combination with canine H3N2 virus was found in the serum samples collected from field dogs during 2010 and 2011. Our results suggest that dogs may be hosts for human seasonal H3N2 and pdm H1N1 influenza viruses.

show abstract

mentioning

confidence: 73%

Canine susceptibility to human influenza viruses (A/pdm 09H1N1, A/H3N2 and B)

Song

Kim

et al. 2015

Journal of General Virology

View full text Add to dashboard Cite

show abstract

“…The practice of backyard farming and live-animal markets (LAMs) contributes to this, due to the constant close proximity of humans to poultry (chicken, ducks, geese, and numerous other species) and other animals (pigs, cats, dogs) (Fig. 2) (23). Pigs are considered the most likely mixing vessels in many backyard farms, producing numerous H1 and H3 reassortant viruses.…”

Section: Potential Reasons Behind the Emergence Of Divergent Aiv Reasmentioning

confidence: 99%

Epidemiology, Evolution, and Recent Outbreaks of Avian Influenza Virus in China

Wong

et al. 2015

J Virol

Self Cite

221

164

View full text Add to dashboard Cite

f Novel reassortants of H7N9, H10N8, and H5N6 avian influenza viruses (AIVs) are currently circulating in China's poultry flocks, occasionally infecting humans and other mammals. Combined with the sometimes enzootic H5N1 and H9N2 strains, this cauldron of genetically diverse AIVs pose significant risks to public health. Here, we review the epidemiology, evolution, and recent outbreaks of AIVs in China, discuss reasons behind the recent increase in the emergence of novel AIVs, and identify warning signs which may point to the emergence of a potentially virulent and highly transmissible AIV to humans. This review will be useful to authorities who consider options for the detection and control of AIV transmission in animals and humans, with the goal of preventing future epidemics and pandemics.

show abstract

“…We also investigated the seroprevalence of human seasonal H1N1 and human seasonal H3N2 in dogs in southern China. Since dogs may be exposed to different influenza virus subtypes, including avian-and human-origin influenza viruses [23,24], coinfection of dogs with different influenza viruses might provide an opportunity for reassortment, leading to the emergence of novel reassortant strains with novel pandemic zoonotic potential. Their potential role in the epidemiology of influenza virus should be investigated further.…”

Section: Discussionmentioning

confidence: 99%

Serological report of pandemic and seasonal human influenza virus infection in dogs in southern China

et al. 2014

View full text Add to dashboard Cite

From January to July 2012, we looked for evidence of subclinical A (H1N1) pdm09 and seasonal human influenza viruses infections in healthy dogs in China. Sera from a total of 1920 dogs were collected from Guangdong, Guangxi, Fujian and Jiangxi provinces. We also examined archived sera from 66 dogs and cats that were collected during 2008 from these provinces. Using hemagglutination inhibition (HI) and microneutralization (MN) assays, we found that only the dogs sampled in 2012 had elevated antibodies (≥ 1:32) against A(H1N1)pdm09 virus and seasonal human influenza viruses: Of the 1920 dog sera, 20.5 % (n = 393) had elevated antibodies against influenza A(H1N1) pdm09 by the HI assay, 1.1 % (n = 22), and 4.7 % (n = 91) of the 1920 dogs sera had elevated antibodies against human seasonal H1N1 influenza virus and human seasonal H3N2 influenza virus by the HI assay. Compared with dogs that were raised on farms, dogs that were raised as pets were more likely to have elevated antibodies against A(H1N1)pdm09 and seasonal human influenza viruses. Seropositivity was highest among pet dogs, which likely had more diverse and frequent exposures to humans than farm dogs. These findings will help us better understand which influenza A viruses are present in dogs and will contribute to the prevention and control of influenza A virus. Moreover, further in-depth study is necessary for us to understand what roles dogs play in the ecology of influenza A.

show abstract

Virological and Epidemiological Evidence of Avian Influenza Virus Infections Among Feral Dogs in Live Poultry Markets, China: A Threat to Human Health?

Cited by 44 publications

References 6 publications

Canine susceptibility to human influenza viruses (A/pdm 09H1N1, A/H3N2 and B)

Canine susceptibility to human influenza viruses (A/pdm 09H1N1, A/H3N2 and B)

Epidemiology, Evolution, and Recent Outbreaks of Avian Influenza Virus in China

Serological report of pandemic and seasonal human influenza virus infection in dogs in southern China

Contact Info

Product

Resources

About