Virtual and remote laboratory for hydraulic plant control

Catch and Anchor Approach To Combat Both Toxicity and Longevity of Botulinum Toxin A

“…51 The most successful inhibitor design for BoNT/A LC, both in vitro and in vivo, has targeted this zinc-binding region and is headlined by hydroxamates, quinolinols, and recently, steroidal 4-aminoquinolines. [24][25][26][27][28][29][30][31][32][33][52][53][54][55][56] Despite their well-known liabilities, hydroxamates remain the most potent BoNT/A LC inhibitors. As such, the hydroxamate functional group was selected for our bifunctional inhibitor design.…”

“…23 The most potent class of BoNT/A inhibitors remains zinc-chelating molecules, particularly those inclusive of a hydroxamic acid pharmacophore. [24][25][26][27][28][29][30][31][32][33] Zinc-chelating inhibitors bind competitively at the BoNT/A active site, directly preventing the association of the substrate with the enzyme catalytic site. While best-in-class reversible inhibitors have achieved sub-micromolar potency and modest protection against BoNT/A challenge in murine models, no drug candidate has reached clinical trials.…”

Sustainable Water Management: Virtual Reality Training for Open-Channel Flow Monitoring

“…Such software allows students to perform some actions similar to those on real hydraulic circuits, such as starting or stopping the electromotor, changing the position of the directional valve, tuning the pressure relief valve to modify its cracking pressure, or changing the area of the throttle valve orifice and the flux rating of the hydraulic pump [17]. More recently, for students of control engineering courses at Slovak University of Technology in Bratislava, Cápková et al [18] designed an interactive simulation tool able to control a nonlinear hydraulic plant in different configurations using a graphical user interface developed in Matlab/Simulink. In the water monitoring sector, Mirauda et al [19,20] implemented an Augmented Reality mobile platform, based on the Metaio framework and multimedia smartphone technology, in order to improve the technical skills of workforces for managing of flood events.…”

StreamflowVL: A Virtual Fieldwork Laboratory that Supports Traditional Hydraulics Engineering Learning

“…The immersive experiences used in Hydraulics can generally be divided into two main categories: 2D virtual hydraulic circuits and 3D virtual hydraulic equipment. 2D animations have been developed using a variety of software or programming technologies, ranging from general programming languages, such as Microsoft Excel [33] and Visual Basic [34], to more professional software including Macromedia Flash [35], Matlab/Simulink [36] and the Metaio framework [37,38]. In particular, Rivas et al [33] presented educational software based on Microsoft Excel spreadsheet, which with its built-in solver, is able to analyse and optimise systems and processes of medium complexity, whose mathematical models are expressed by means of nonlinear systems of equations.…”

“…In this way, students can perform actions similar to those of real hydraulic circuits, such as starting or stopping the electromotor, changing the position of the directional valve, tuning the pressure relief valve to modify its cracking pressure, or changing the area of the throttle valve orifice and the flux rating of the hydraulic pump. More recently, Cápková et al [36] designed an interactive simulation tool for students in control engineering courses at the Slovak University of Technology in Bratislava that is able to control a nonlinear hydraulic plant in different configurations using a graphical user interface developed in Matlab/Simulink. These virtual experiments allow for changing the plant configuration and also applying various control structures, switching between simulations and real conditions, and implementing the control locally or via the Internet.…”