Current medical students need an ongoing basis of updated skills and knowledge to be compatible with the development of health care systems in the hospitals. The student engagement in thinking about the better way for learning a new information and skills will create safe and comfortable learning environment, which act as a golden key to starting point, leading to highest quality learning outcomes. The medical education instructor should recognize the e-learning technology gadget suited the required learning environment and compatible with intended learning objectives for each lecture. No doubt that the instructor plays a vital role in the student support, which needs an intellectual efforts to provide them with appropriate needs and guide students to become active and creative members in the university, their profession, and community. This research aims to find out what is the impact of electronic courses (e-courses) in instructional support, to increase medical students' enthusiasm. Across sectional descriptive analytical study conducted in King Saud University, Riyadh, Kingdom of Saudi Arabia (KSA), the study population was undergraduate radiological sciences students. A well-designed questionnaire was distributed to students and then received their feedback. In the first part of the course, they exposed to traditional methods, while in the remaining part, the e-learning and interactive lectures were introduced. Statistical analyses were performed with Statistic Package for Social Science (SPSS software version 20). Out of 50 students, 31 (62.0%) preferred the interactive power points files, 33 (66.0%) more enthusiastic to use learning management system (LMS) to find out their course contents. Regarding the level of students satisfaction in different types of pre-test, 30 (60.0%) students were unsatisfied when using paper and pen style, while 38 (76.0%) were satisfied when performing an electronic tests. Twenty-nine (58.50%) favoured an interactive mind map for each lecture contents. Majority of students decided that both classical and electronic instruction methods offer usable and relevant support for students. In conclusion, the e-courses offer the opportunity to integrate teaching, learning, and assessment which play a vital role in instructional support, to increase medical students' enthusiasm. The web utilization supports both faculties and students with a very strong and dynamic communication method, to set up a vital learning community. The e-courses provide students with multiple ways to prove mastery, offer more options and opportunities for presentation and participation, become creative and critical thinkers, and continue self-directed learning.