Modern manufacturing platforms are defined by the quest for increased automation throughout the production cycle. This continuing pressure towards automation dictates that emergent technologies are leveraged towards this goal. Unfortunately, this increasing automation brings additional complexity and production issues. To address these challenges, this paper discusses the methods developed and deployed by our team (USC neXt) to employ (1) large-scale simulation, (2) system health monitoring sensors, and (3) advanced computational technologies to establish a life-like digital manufacturing platform and to capture, represent, predict, and control the dynamics of a live manufacturing cell. A machine learning based Digital Engine will be used to dynamically control and schedule operations in the live manufacturing cell, based on simulation results and real time data. Sensors, such as load cells, accelerometers, robot monitors, and thermal cameras will connect to digital twin systems, collecting and sharing accurate real-time plant descriptions between stakeholders. By creating our future factory using an Industrial Internet of Things (IIoT) platform, we will present data-driven science and engineering solutions to our industrial partners, accelerating the Smart Manufacturing Innovation. Future work will focus on applying the proposed methodology on more diverse manufacturing tasks and material flow, including collaborative assembly jobs, visual inspection, and continuous movement tasks.