This paper presents the findings of exploratory research on the potential of semiotics for manufacturing systems integration (MSI). The findings strongly suggest that semiotics might be the basis for a new paradigm for MSI. In the first part of the paper a number of needs for the new semiotic-based integration paradigm are presented. The second part of the paper introduces the basic notions of semiotics and provides a discussion on the use of semiotics in MSI. The third part presents a framework for the semiotics-based MSI, together with a model of the semioticsbased MSI, entitled 'generative integration' (GI). In the final part, some experimental set-ups, i.e. prototype demonstrators of the manufacturing systems, elements and systems, are presented as a platform for future research and development of the semiotics-based MSI.