Virtual implantations to transition from porcine to bovine animal models for a total artificial heart

Sonntag, Simon J.; Meyns, Bart; Ahn, Henrik Casimir; Pahlm, Fredrik; Hellers, G; Najar, Azad; Pieper, Ina Laura

doi:10.1111/aor.13578

Cited by 5 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Realheart® TAH has been tested acutely in pigs and it has proven to elicit a pulsatile blood pressure in the circulatory system 9,10 . The outer design of the device was developed using virtual implants and cadaver studies in calves and humans, to ensure anatomical compatibility for chronic animal studies and clinical trials 11,12 …”

Section: Methodsmentioning

confidence: 99%

Hemodynamic characterization of the Realheart® total artificial heart with a hybrid cardiovascular simulator

Fresiello

Najar²,

Ignell³

et al. 2022

Artificial Organs

Self Cite

View full text Add to dashboard Cite

Background: Heart failure is a growing health problem worldwide. Due to the lack of donor hearts there is a need for alternative therapies, such as total artificial hearts (TAHs). The aim of this study is to evaluate the hemodynamic performance of the Realheart® TAH, a new 4-chamber cardiac prosthesis device. Methods:The Realheart® TAH was connected to a hybrid cardiovascular simulator with inflow connections at the left/right atrium, and outflow connections at the ascending aorta/pulmonary artery. The Realheart® TAH was tested at different pumping rates and stroke volumes. Different systemic resistances (20.0-16.7-13.3-10.0 Wood units), pulmonary resistances (6.7-3.3-1.7 Wood units), and pulmonary/systemic arterial compliances (1.4-0.6 ml/mm Hg) were simulated. Tests were also conducted in static conditions, by imposing predefined values of preload-afterload across the artificial ventricle. Results:The Realheart® TAH allows the operator to finely tune the delivered flow by regulating the pumping rate and stroke volume of the artificial ventricles. For a systemic resistance of 16.7 Wood units, the TAH flow ranges from 2.7 ± 0.1 to 6.9 ± 0.1 L/min. For a pulmonary resistance of 3.3 Wood units, the TAH flow ranges from 3.1 ± 0.0 to 8.2 ± 0.3 L/min. The Realheart® TAH delivered a pulse pressure ranging between ~25 mm Hg and ~50 mm Hg for the tested conditions. Conclusions:The Realheart® TAH offers great flexibility to adjust the output flow and delivers good pressure pulsatility in the vessels. Low sensitivity of device flow to the pressure drop across it was identified and a new version is under development to counteract this.

show abstract

Section: Methodsmentioning

confidence: 99%

Hemodynamic characterization of the Realheart® total artificial heart with a hybrid cardiovascular simulator

Fresiello

Najar²,

Ignell³

et al. 2022

Artificial Organs

Self Cite

View full text Add to dashboard Cite

show abstract

“…The computational model was developed for the Realheart V11c, a legacy prototype device that was used in acute bovine trials 40 , and has extensive in vitro data available for validation of the computational model. Newer versions of the Realheart TAH, both at prototype and concept stages, function similarly but have geometric variations, therefore it will be straightforward to extend the modelling to these after validation.…”

Section: Methodsmentioning

confidence: 99%

Fluid–structure interaction modelling of a positive-displacement Total Artificial Heart

Bornoff

Najar²,

Fresiello

et al. 2023

Sci Rep

Self Cite

View full text Add to dashboard Cite

For those suffering from end-stage biventricular heart failure, and where a heart transplantation is not a viable option, a Total Artificial Heart (TAH) can be used as a bridge to transplant device. The Realheart TAH is a four-chamber artificial heart that uses a positive-displacement pumping technique mimicking the native heart to produce pulsatile flow governed by a pair of bileaflet mechanical heart valves. The aim of this work was to create a method for simulating haemodynamics in positive-displacement blood pumps, using computational fluid dynamics with fluid–structure interaction to eliminate the need for pre-existing in vitro valve motion data, and then use it to investigate the performance of the Realheart TAH across a range of operating conditions. The device was simulated in Ansys Fluent for five cycles at pumping rates of 60, 80, 100 and 120 bpm and at stroke lengths of 19, 21, 23 and 25 mm. The moving components of the device were discretised using an overset meshing approach, a novel blended weak–strong coupling algorithm was used between fluid and structural solvers, and a custom variable time stepping scheme was used to maximise computational efficiency and accuracy. A two-element Windkessel model approximated a physiological pressure response at the outlet. The transient outflow volume flow rate and pressure results were compared against in vitro experiments using a hybrid cardiovascular simulator and showed good agreement, with maximum root mean square errors of 15% and 5% for the flow rates and pressures respectively. Ventricular washout was simulated and showed an increase as cardiac output increased, with a maximum value of 89% after four cycles at 120 bpm 25 mm. Shear stress distribution over time was also measured, showing that no more than $$4.5\times 10^{-4}$$ 4.5 × 10 - 4 % of the total volume exceeded 150 Pa at a cardiac output of 7 L/min. This study showed this model to be both accurate and robust across a wide range of operating points, and will enable fast and effective future studies to be undertaken on current and future generations of the Realheart TAH.

show abstract

“…We have identified three mechanically actuated devices that are still under development: Realheart TAH (Linköping University, Linköping, Sweden) 73,74 , ReinHeart (Helmholtz Institute, Aachen, Germany) 75 and RollingHeart (University of Lausanne, Lausanne, Switzerland) 76 . None of these devices has been assessed in clinical trials.…”

Section: Current Devicesmentioning

confidence: 99%

The ongoing quest for the first total artificial heart as destination therapy

et al. 2022

View full text Add to dashboard Cite

published version features the final layout of the paper including the volume, issue and page numbers. Link to publication General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal.If the publication is distributed under the terms of Article 25fa of the Dutch Copyright Act, indicated by the "Taverne" license above, please follow below link for the End User

show abstract

Virtual implantations to transition from porcine to bovine animal models for a total artificial heart

Cited by 5 publications

References 23 publications

Hemodynamic characterization of the Realheart® total artificial heart with a hybrid cardiovascular simulator

Hemodynamic characterization of the Realheart® total artificial heart with a hybrid cardiovascular simulator

Fluid–structure interaction modelling of a positive-displacement Total Artificial Heart

The ongoing quest for the first total artificial heart as destination therapy

Contact Info

Product

Resources

About