Traditional Chinese Medicine (TCM) plays an important role in SouthEast Asia, and increasingly in the West. However, learning and mastering TCM knowledge are still an obscure problem for researchers all over the world, especially for beginners. With the development of computer science, serious game rising in a wide range of fields like education, training and simulation, etc. In this paper, we design and implementation a knowledge-intensive serious game for education of TCM. When the users play this game, they will finding learning is an interesting thing. We chose the Unity 3D as our game engine, 3ds Max 2013 as model design tools. When the users log in the game, it will presents a series of scenes include some tasks and questions about the TCM knowledge. After a series tasks and test, the reslut shows that serious game for TCM education proved effective to help the user remember and comprehend the concept of TCM.