“…Serotonin is a selective serotonin reuptake inhibitor, an essential neurotransmitter in frontal subcortical pathways, and loss of serotonergic binding is documented in bvFTD [ 8 , 10 ]. Early case reports and case series studies using selective serotonin reuptake inhibitors (including fluoxetine, sertraline, and paroxetine) have some efficacy in treating compulsion, hyperorality, depression, inappropriate sexual behavior, and disinhibition of patients with bvFTD [ 8 , 12 ]. There is limited evidence that antidepressants such as selective serotonin reuptake inhibitors (SSRIs), such as citalopram, or trazodone, are used to improve behavioral symptoms, including impulsivity, disinhibition, agitation/irritability, or compulsive behaviors [ 7 , 9 ].…”