The Hunga Tonga‐Hunga Ha'apai volcanic eruption on 15 January 2022 had a significant impact on the ionosphere‐thermosphere system, resulting in large‐scale ionospheric irregularities with longitudinal and latitudinal asymmetries. Multiple instruments recorded these irregularities, indicating the propagation of a westward wave at an average velocity of 354 ± 8 m/s, which led to plasma irregularities of 0.2 TECu/min. Conversely, an eastward‐propagating wave was detected on the Pacific's east coast, traveling at a speed of 348 ± 6 m/s, with a corresponding decrease in plasma fluctuations to 0.1 TECu/min. In Asia, noticeable plasma irregularities appeared within a few hours after the eruption, and the maximum speed exceeded 1,100 m/s, which cannot be explained by the acoustic wave model. There was also a significant latitudinal asymmetry of ionospheric disturbances in the Asian‐Oceania sector, with the plasma density around Oceania depleted by 2–3 orders of magnitude within the altitudes of ∼150–575 km, while the ion density over Asia was enhanced by 1–2 orders of magnitude, and was uplifted ∼50 km. The plasma temperature was proportional to ion density, indicating the ion temperature reduced ∼500 K and increased 100–200 K around Oceania and Asia, respectively. The equatorial electric field, vertical E × B drifts and thermospheric O/N2 density ratio also fluctuated significantly following the eruption, indicating the redistribution of charged particles due to the magnetic field mapping effect, which was the main contributor to the asymmetries observed.