Virtual screening of synthesized thiazole derivatives for M. tuberculosis and dTDP-rhamnose inhibitors

Abstract

To determine antimycobacterium and dTDP rhamnose inhibitor activity of the synthesized azetidinone, thiazolidinone derivatives of thiazole, we studied different derivatives for the activity. One pot synthesis of 2-amino-4-methylthiazole-5-carboxylic acid ethyl ester has been carried out and synthesized different derivative compounds. Compounds were tested for antimicrobial activity against different strains of microorganism and antitubercular activity against M. tuberculosis H37Rv. Compounds 7c, 7d, 7i, 8d, 8e, 8g and 8h, were showed antimicrobial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhosa using Gentamycin as standard, while 7b, 7e, 7f, 7i, 8b, 8e, 8f and 8i showed very strong antimycobacterial activity using rifampicine as a standard. Thiazole derivatives especially with carbonyl group scaffold inhibit an enzyme RmlC, which is an essential component for the biosynthesis of dTDP-rhamnose and produce good antimycobacterium and antimicrobial activity.

Development of Thiazolidinone-Based Pyrazine Derivatives: Synthesis, Molecular Docking Simulation, and Bioevaluation for Anti-Alzheimer and Antibacterial Activities

“…However, certain pyrazines are toxic, such as those that impede cytochrome P450 synthesis [27] or activate liver microsomal explode hydrolase, an enzyme used in mammalian detoxifcation [28,29]. As pyrazine and thiazolidnone moieties are biologically active [30][31][32][33][34][35][36][37][38][39][40], herein the current work, Ncontaining derivatives such as pyrazine-based thiazolidinone derivatives were synthesized and tested for biological activity to analyze their substantial impacts on Alzheimer's disease. Furthermore, the inhibitory actions were investigated further using molecular docking investigations (Figure 1).…”