Virtual simulation of an osseointegrated trans-humeral prosthesis: A falling scenario

Mirulla, Agostino Igor; Bragonzoni, Laura; Zaffagnini, Stefano; Bontempi, Marco; Nigrelli, Vincenzo; Ingrassia, Tommaso

doi:10.1016/j.injury.2018.03.004

Cited by 17 publications

(12 citation statements)

References 12 publications

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“…The application of interdisciplinary technology has been rapidly developed. There are many reports on application of virtual simulation technology to solve medical problems [ 146 , 147 ]. Recently, virtual simulation technology also has been applied for the study of LSCs.…”

Section: Prospectivesmentioning

confidence: 99%

An Insight into the Difficulties in the Discovery of Specific Biomarkers of Limbal Stem Cells

Guo

Zhang

Jia

et al. 2018

IJMS

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Keeping the integrity and transparency of the cornea is the most important issue to ensure normal vision. There are more than 10 million patients going blind due to the cornea diseases worldwide. One of the effective ways to cure corneal diseases is corneal transplantation. Currently, donations are the main source of corneas for transplantation, but immune rejection and a shortage of donor corneas are still serious problems. Graft rejection could cause transplanted cornea opacity to fail. Therefore, bioengineer-based corneas become a new source for corneal transplantation. Limbal stem cells (LSCs) are located at the basal layer in the epithelial palisades of Vogt, which serve a homeostatic function for the cornea epithelium and repair the damaged cornea. LSC-based transplantation is one of the hot topics currently. Clinical data showed that the ratio of LSCs to total candidate cells for a transplantation has a significant impact on the effectiveness of the transplantation. It indicates that it is very important to accurately identify the LSCs. To date, several putative biomarkers of LSCs have been widely reported, whereas their specificity is controversial. As reported, the identification of LSCs is based on the characteristics of stem cells, such as a nuclear-to-cytoplasm ratio (N/C) ≥ 0.7, label-retaining, and side population (SP) phenotype. Here, we review recently published data to provide an insight into the circumstances in the study of LSC biomarkers. The particularities of limbus anatomy and histochemistry, the limits of the current technology level for LSC isolation, the heterogeneity of LSCs and the influence of enzyme digestion are discussed. Practical approaches are proposed in order to overcome the difficulties in basic and applied research for LSC-specific biomarkers.

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Section: Prospectivesmentioning

confidence: 99%

An Insight into the Difficulties in the Discovery of Specific Biomarkers of Limbal Stem Cells

Guo

Zhang

Jia

et al. 2018

IJMS

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“…Moreover, it has been shown that FE models can be used to predict fracture healing [26,28,29]. For these reasons, in this work, an FEM-based approach was used and virtual simulations [30,31] performed using the commercial software Ansys After analysing some commercial tibial plates, it emerged that the angle of the screws mainly varied from about −7 • to 10 • . For this reason, the authors decided to study different configurations by varying the angle of the screws from −5 • to 10 • .…”

Section: Fem Analysesmentioning

confidence: 99%

“…Moreover, it has been shown that FE models can be used to predict fracture healing [26,28,29]. For these reasons, in this work, an FEM-based approach was used and virtual simulations [30,31] performed using the commercial software Ansys Workbench R.18 (Ansys Inc., Canonsburg, PA, USA, 2018). All finite element analyses were performed using a Dell Precision T7810 workstation with a 24-core Intel Xeon E5-2670 processor and 128 GB of RAM.…”

Section: Fem Analysesmentioning

confidence: 99%

Influence of the Screw Positioning on the Stability of Locking Plate for Proximal Tibial Fractures: A Numerical Approach

et al. 2020

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Tibial fractures are common injuries in people. The proper treatment of these fractures is important in order to recover complete mobility. The aim of this work was to investigate if screw positioning in plates for proximal tibial fractures can affect the stability of the system, and if it can consequently influence the patient healing time. In fact, a more stable construct could allow the reduction of the non-weight-bearing period and consequently speed up the healing process. For that purpose, virtual models of fractured bone/plate assemblies were created, and numerical simulations were performed to evaluate the reaction forces and the maximum value of the contact pressure at the screw/bone interface. A Schatzker type I tibial fracture was considered, and four different screw configurations were investigated. The obtained results demonstrated that, for this specific case study, screw orientation affected the pressure distribution at the screw/bone interface. The proposed approach could be used effectively to investigate different fracture types in order to give orthopaedists useful guidelines for the treatment of proximal tibial fractures.

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“…To verify the structural strength of the prototype [26,27], biomechanical FEM analyses have been executed [3,28,29]. These FEM analyses were carried out only on the structural parts of the orthosis.…”

Section: Fem Analysesmentioning

confidence: 99%

A new design approach for customised medical devices realized by additive manufacturing

Ricotta

Campbell

Ingrassia

et al. 2020

Int J Interact Des Manuf

Self Cite

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The aim of this work is the design of a new customised elbow orthosis completely realized by Additive Manufacturing and the development of generative algorithms for parametric modelling and creation of 3D patterns to be adapted to the CAD model. This work describes a method to perfect the design of a custom elbow orthosis. A reverse engineering approach has been used to digitalize the patient’s arm and the subsequent CAD modelling of the structure of the custom elbow orthosis has been performed. In particular, two algorithms have been implemented for the creation of 3D patterns and Voronoi tessellations. Subsequently, FEM analyses have been carried out to validate the design. Finally, a prototype of the elbow orthosis with Voronoi tessellation has been realized by means of the SLS technology. The results obtained have demonstrated that the implemented algorithm solved the problems found during CAD modelling with conventional software. Furthermore, the results of FEM analyses have validated the design choices. All this allowed realizing the prototype by AM technologies without problems. Moreover, the new proposed modelling approaches allows creating, in an interactive way, patterns on complex surfaces. The results of this research activity present innovative elements of originality in the CAD modelling sector, which can contribute to solving problems related to the modelling for Additive Manufacturing. Furthermore, another innovative characteristic of the device is the use of torsion springs that simulate the action of physiotherapists during exercises for patient rehabilitation.

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Virtual simulation of an osseointegrated trans-humeral prosthesis: A falling scenario

Cited by 17 publications

References 12 publications

An Insight into the Difficulties in the Discovery of Specific Biomarkers of Limbal Stem Cells

An Insight into the Difficulties in the Discovery of Specific Biomarkers of Limbal Stem Cells

Influence of the Screw Positioning on the Stability of Locking Plate for Proximal Tibial Fractures: A Numerical Approach

A new design approach for customised medical devices realized by additive manufacturing

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