The correction of malocclusions with severe skeletal deformity generally requires surgery combined with orthodontic or prosthodontic treatment; partially or totally edentulous patients, and patients with a prosthetic fixed crown, represent treatment restrictions and, therefore, challenges. The purpose of this study is to show a complete multidisciplinary approach and the planning involved (pre-, intra-, and post-operative) for a patient with a class-II or -III dento-skeletal malformation, who presents a total or partial edentulism or a fixed-type rehabilitation and, therefore, requires a combined orthognathic surgical treatment with prosthetic rehabilitation. Orthognathic surgery can be performed on an edentulous or prosthodontic patient to correct discrepancies between the jaws, followed by the placement of implants or a mobile prosthesis to rehabilitate the maxillary bones maxillary Different surgical approaches and technical variations have been proposed; however, the key to the success of such treatments lies in the multidisciplinary nature of the entire diagnostic, programmatic, and therapeutic path, which, therefore, necessitates close collaboration between different specialists—in particular, the maxillofacial surgeon, the orthodontist, and the prosthetist.