Virucidal activities of novel hand hygiene and surface disinfectant formulations containing EGCG-palmitates (EC16)

Dickinson, Douglas; Marsh, Bianca; Shao, Xueling; Liu, Emma; Sampath, Lester; Yao, Bo; Jiang, Xiaocui; Hsu, Stephen

doi:10.1016/j.ajic.2022.05.027

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…However, this result could not be reproduced by other groups (e.g. [3,4] ethanol [5]. It is known that phosphoric acid can be very hazardous in the case of skin contact, eye contact, and ingestion.…”

Section: Introductionmentioning

confidence: 77%

"How Much Effect Does Alcohol Have Against Alcohol- Resistant Norovirus?"

Hsu¹

2022

BJSTR

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Section: Introductionmentioning

confidence: 77%

"How Much Effect Does Alcohol Have Against Alcohol- Resistant Norovirus?"

Hsu¹

2022

BJSTR

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“…Herpesvirus can be inactivated with 70% alcohol solutions as well, presenting fewer material surface incompatibility concerns. 37 Non-surface-based disinfectant options including hydrogen peroxide vapor and UV irradiation may also play a role in viral gene vector therapy disinfection protocols, however, effectiveness is dependent upon multiple factors including burden of organic matter which limits their usage as a primary disinfection agent.…”

Section: Discussionmentioning

confidence: 99%

A comprehensive literature scoping review of infection prevention and control methods for viral-mediated gene therapies

Blind,

Ghosh,

Niese

et al. 2024

ASHE

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Objective: This comprehensive literature scoping review outlines available infection prevention and control (IPC) methods for viral-mediated gene therapies and provides one IPC strategy for the healthcare setting based on a single-center recommendation. Methods: A team of experts in pharmacy, healthcare epidemiology, and biosafety with experience in viral-mediated gene therapy was assembled within a pediatric hospital to conduct a comprehensive literature scoping review. The comprehensive review included abstracts and full-text articles published since 2009 and utilized prespecified search terms of the five viral vectors of interest: adenovirus (AV), retrovirus (RV), adeno-associated virus (AAV), lentivirus (LV), and herpes simplex virus (HSV). Case reports, randomized controlled trials, and bench research studies were all included, while systematic reviews were excluded. Results: A total of 4473 case reports, randomized control trials, and benchtop research studies were identified using the defined search criteria. Chlorine compounds were found to inactivate AAV and AV, while alcohol-based disinfectants were ineffective. There was a relative paucity of studies investigating surface-based disinfection for HSV, however, alcohol-based disinfectants were effective in one study. Ultraviolent irradiation was also found to inactivate HSV in numerous studies. No studies investigated disinfection for LV and RV vectors. Conclusions: The need to define IPC methods is high due to the rapid emergence of viral-mediated gene therapies to treat rare diseases, but published clinical guidance remains scarce. In the absence of these data, our center recommends a 1:10 sodium hypochlorite solution in clinical and academic environments to ensure complete germicidal activity of viral-mediated gene therapies.

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“…Tea polyphenols have multiple biomedical functions, with active components like epigallocatechin gallate (EGCG) and epigallocatechin-3-gallate-palmitate (EC16) directly damaging the cell membrane, altering cell structure, and affecting the proteins and DNA of microorganisms to exhibit antimicrobial effects. In particular, EC16, the main component of tea polyphenol palmitate, has emerged as a novel safe and non-toxic HSG component [ 103 , 104 ]. Research by M. Xi et al has found luteolin (LUT) to be a highly promising antimicrobial functional component of hand sanitizers.…”

Section: Novel Antimicrobial Ingredients Of Hsgsmentioning

confidence: 99%

Hand Sanitizer Gels: Classification, Challenges, and the Future of Multipurpose Hand Hygiene Products

Ma,

Yi,

et al. 2023

Toxics

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Hand hygiene is a crucial measure in the prevention and control of infections, and there is a growing awareness among individuals who are making a conscious effort to maintain hand cleanliness. With the advent of the SARS-CoV-2 outbreak, the demand for hand hygiene products has also gradually shifted towards those with antimicrobial properties. Among these products, hand sanitizer gels (HSGs) have gained considerable popularity as an efficient method of hand cleaning, due to their rapid drying and sustained antimicrobial efficacy. Concurrently, there has been a growing interest in novel HSGs that offer additional functions such as skin whitening, moisturizing, and anti-inflammatory effects. These novel HSGs effectively address concerns associated with the ingestion of antimicrobial ingredients and demonstrate reduced skin irritation, thereby alleviating hand dermatological issues. This review provides an extensive overview of the application scenarios, classification, and challenges associated with HSGs while emphasizing the emergence of novel components with biological functions, aiming to contribute to the advancement of hand hygiene practices and offer novel insights for the development of novel HSGs with outstanding antimicrobial properties with other multiple biological functions and desirable biosafety profiles.

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Virucidal activities of novel hand hygiene and surface disinfectant formulations containing EGCG-palmitates (EC16)

Cited by 5 publications

References 18 publications

"How Much Effect Does Alcohol Have Against Alcohol- Resistant Norovirus?"

"How Much Effect Does Alcohol Have Against Alcohol- Resistant Norovirus?"

A comprehensive literature scoping review of infection prevention and control methods for viral-mediated gene therapies

Hand Sanitizer Gels: Classification, Challenges, and the Future of Multipurpose Hand Hygiene Products

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