Virucidal activity of oral, hand, and surface disinfectants against respiratory syncytial virus

Meister, T.L.; Friesland, M.; Frericks, N.; Wetzke, M.; Haid, S.; Steinmann, J.; Todt, D.; Pietschmann, T.; Steinmann, E.

doi:10.1016/j.jhin.2023.08.009

Cited by 5 publications

(2 citation statements)

References 49 publications

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“…The WHO proposed in its 2009 Guidelines on Hand Hygiene in Health Care the use of 2 alcohol-based hand rubs (formulation I and formulation II) for surgical and hygiene hand disinfection in healthcare settings to reduce the transmission of pathogens by hands [ 17 , 25 ]. We and others have recently shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), middle east respiratory syndrome coronavirus (MERS-CoV), SARS, Mpox virus (MPXV), and other viruses were also inactivated by these hand-rub formulations and alcohols [ 15 ]. These findings were replicated for YFV, which was highly susceptible to inactivation when exposed to WHO formulations I and II compared to other emerging viruses, with a comparable profile to the closely related ZIKV.…”

Section: Discussionmentioning

confidence: 99%

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Inactivation of yellow fever virus by WHO-recommended hand rub formulations and surface disinfectants

Meister,

Frericks,

Kleinert

et al. 2024

PLoS Negl Trop Dis

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Despite continued outbreaks of yellow fever virus (YFV) in endemic regions, data on its environmental stability or guidelines for its effective inactivation is limited. Here, we evaluated the susceptibility of the YFV 17D vaccine strain to inactivation by ethanol, 2-propanol, World Health Organization (WHO)-recommended hand rub formulations I and II, as well as surface disinfectants. In addition, two pathogenic strains were tested to compare inactivation kinetics by WHO-recommended hand rub formulations I and II. Furthermore, environmental stability of the vaccine strain was assessed. YFV 17D particles displayed infectivity half-life decay profiles of ~13 days at room temperature. Despite this extended environmental stability, YFV was efficiently inactivated by alcohols, WHO-recommended hand formulations, and four out of five tested surface disinfectants. These results are useful in defining disinfection protocols to prevent non-vector borne YFV transmission.

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Section: Discussionmentioning

confidence: 99%

“…Nine parts YFV 17D and one-part interfering substance (BSA, final concentration 0.3 g/L, clean condition) were combined in a tube according to our previous study [ 15 ]. The virus solutions were stored at room temperature (RT: 21°C) and at 4°C.…”

Section: Methodsmentioning

confidence: 99%